Ruthenium and Iron-Catalysed Decarboxylative N-alkylation of Cyclic α-Amino Acids with Alcohols: Sustainable Routes to Pyrrolidine and Piperidine DerivativesAfanasenko, A., Hannah, R., Yan, T., Elangovan, S. & Barta, K., 22-Aug-2019, In : Chemsuschem. 12, 16, p. 3801-3807 7 p.
Research output: Contribution to journal › Article › Academic › peer-review
A modular and waste-free strategy for constructing N-substituted cyclic amines via decarboxylative N-alkylation of α-amino acids employing ruthenium- and iron-based catalysts is presented. The reported method allows the synthesis of a wide range of five- and six-membered N-alkylated heterocycles in moderate-to-excellent yields starting from predominantly proline and a broad range of benzyl alcohols, and primary and secondary aliphatic alcohols. Examples using pipecolic acid for the construction of piperidine derivatives, as well as the one-pot synthesis of α-amino nitriles, are also shown.
|Number of pages||7|
|Early online date||22-Jul-2019|
|Publication status||Published - 22-Aug-2019|
- AZOMETHINE YLIDES, BOND FORMATION, PROLINE, AMINATION, ACTIVATION, COMPLEXES, MECHANISM, PYRIDINE, OXIDE