Publication

Running wheel access fails to resolve impaired sustainable health in mice feeding a high fat sucrose diet

Reijne, A. C., Talarovicova, A., Ciapaite, J., Bruggink, J. E., Bleeker, A., Groen, A. K., Reijngoud, D-J., Bakker, B. M. & van Dijk, G., 15-Mar-2019, In : Aging. 11, 5, p. 1564-1579 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Reijne, A. C., Talarovicova, A., Ciapaite, J., Bruggink, J. E., Bleeker, A., Groen, A. K., ... van Dijk, G. (2019). Running wheel access fails to resolve impaired sustainable health in mice feeding a high fat sucrose diet. Aging, 11(5), 1564-1579. https://doi.org/10.18632/aging.101857

Author

Reijne, Aaffien C. ; Talarovicova, A. ; Ciapaite, Jolita ; Bruggink, J. E. ; Bleeker, A. ; Groen, Albert K. ; Reijngoud, Dirk-Jan ; Bakker, Barbara M. ; van Dijk, Gertjan. / Running wheel access fails to resolve impaired sustainable health in mice feeding a high fat sucrose diet. In: Aging. 2019 ; Vol. 11, No. 5. pp. 1564-1579.

Harvard

Reijne, AC, Talarovicova, A, Ciapaite, J, Bruggink, JE, Bleeker, A, Groen, AK, Reijngoud, D-J, Bakker, BM & van Dijk, G 2019, 'Running wheel access fails to resolve impaired sustainable health in mice feeding a high fat sucrose diet', Aging, vol. 11, no. 5, pp. 1564-1579. https://doi.org/10.18632/aging.101857

Standard

Running wheel access fails to resolve impaired sustainable health in mice feeding a high fat sucrose diet. / Reijne, Aaffien C.; Talarovicova, A.; Ciapaite, Jolita; Bruggink, J. E.; Bleeker, A.; Groen, Albert K.; Reijngoud, Dirk-Jan; Bakker, Barbara M.; van Dijk, Gertjan.

In: Aging, Vol. 11, No. 5, 15.03.2019, p. 1564-1579.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Reijne AC, Talarovicova A, Ciapaite J, Bruggink JE, Bleeker A, Groen AK et al. Running wheel access fails to resolve impaired sustainable health in mice feeding a high fat sucrose diet. Aging. 2019 Mar 15;11(5):1564-1579. https://doi.org/10.18632/aging.101857


BibTeX

@article{f8185624e93e482c8a11f5d04423af9d,
title = "Running wheel access fails to resolve impaired sustainable health in mice feeding a high fat sucrose diet",
abstract = "Diet and physical activity are thought to affect sustainable metabolic health and survival. To improve understanding, we studied survival of mice feeding a low-fat (LF) or high-saturated fat/high sugar (HFS) diet, each with or without free running wheel (RW) access. Additionally several endocrine and metabolic health indices were assessed at 6, 12, 18 and 24 months of age. As expected, HFS feeding left-shifted survival curve of mice compared to LF feeding, and this was associated with increased energy intake and increased (visceral/total) adiposity, liver triglycerides, and increased plasma cholesterol, corticosterone, HOMA-IR, and lowered adiponectin levels. Several of these health parameters improved (transiently) by RW access in HFS and LF fed mice (i.e., HOMA-IR, plasma corticosterone), others however deteriorated (transiently) by RW access only in HFS-fed mice (i.e., body adiposity, plasma resistin, and free cholesterol levels). Apart from these multiple and sometimes diverging health effects of RW access, RW access did not affect survival curves. Important to note, voluntary RW activity declined with age, but this effect was most pronounced in the HFS fed mice. These results thus challenge the hypothesis that voluntary wheel running can counteract HFS-induced deterioration of survival and metabolic health.",
author = "Reijne, {Aaffien C.} and A. Talarovicova and Jolita Ciapaite and Bruggink, {J. E.} and A. Bleeker and Groen, {Albert K.} and Dirk-Jan Reijngoud and Bakker, {Barbara M.} and {van Dijk}, Gertjan",
year = "2019",
month = "3",
day = "15",
doi = "10.18632/aging.101857",
language = "English",
volume = "11",
pages = "1564--1579",
journal = "Aging",
issn = "1945-4589",
publisher = "Impact Journals LLC",
number = "5",

}

RIS

TY - JOUR

T1 - Running wheel access fails to resolve impaired sustainable health in mice feeding a high fat sucrose diet

AU - Reijne, Aaffien C.

AU - Talarovicova, A.

AU - Ciapaite, Jolita

AU - Bruggink, J. E.

AU - Bleeker, A.

AU - Groen, Albert K.

AU - Reijngoud, Dirk-Jan

AU - Bakker, Barbara M.

AU - van Dijk, Gertjan

PY - 2019/3/15

Y1 - 2019/3/15

N2 - Diet and physical activity are thought to affect sustainable metabolic health and survival. To improve understanding, we studied survival of mice feeding a low-fat (LF) or high-saturated fat/high sugar (HFS) diet, each with or without free running wheel (RW) access. Additionally several endocrine and metabolic health indices were assessed at 6, 12, 18 and 24 months of age. As expected, HFS feeding left-shifted survival curve of mice compared to LF feeding, and this was associated with increased energy intake and increased (visceral/total) adiposity, liver triglycerides, and increased plasma cholesterol, corticosterone, HOMA-IR, and lowered adiponectin levels. Several of these health parameters improved (transiently) by RW access in HFS and LF fed mice (i.e., HOMA-IR, plasma corticosterone), others however deteriorated (transiently) by RW access only in HFS-fed mice (i.e., body adiposity, plasma resistin, and free cholesterol levels). Apart from these multiple and sometimes diverging health effects of RW access, RW access did not affect survival curves. Important to note, voluntary RW activity declined with age, but this effect was most pronounced in the HFS fed mice. These results thus challenge the hypothesis that voluntary wheel running can counteract HFS-induced deterioration of survival and metabolic health.

AB - Diet and physical activity are thought to affect sustainable metabolic health and survival. To improve understanding, we studied survival of mice feeding a low-fat (LF) or high-saturated fat/high sugar (HFS) diet, each with or without free running wheel (RW) access. Additionally several endocrine and metabolic health indices were assessed at 6, 12, 18 and 24 months of age. As expected, HFS feeding left-shifted survival curve of mice compared to LF feeding, and this was associated with increased energy intake and increased (visceral/total) adiposity, liver triglycerides, and increased plasma cholesterol, corticosterone, HOMA-IR, and lowered adiponectin levels. Several of these health parameters improved (transiently) by RW access in HFS and LF fed mice (i.e., HOMA-IR, plasma corticosterone), others however deteriorated (transiently) by RW access only in HFS-fed mice (i.e., body adiposity, plasma resistin, and free cholesterol levels). Apart from these multiple and sometimes diverging health effects of RW access, RW access did not affect survival curves. Important to note, voluntary RW activity declined with age, but this effect was most pronounced in the HFS fed mice. These results thus challenge the hypothesis that voluntary wheel running can counteract HFS-induced deterioration of survival and metabolic health.

U2 - 10.18632/aging.101857

DO - 10.18632/aging.101857

M3 - Article

VL - 11

SP - 1564

EP - 1579

JO - Aging

JF - Aging

SN - 1945-4589

IS - 5

ER -

ID: 78921021