Publication

Role of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence

Milanzi, E. B., Koppelman, G. H., Smit, H. A., Wijga, A. H., Vonk, J. M., Brunekreef, B. & Gehring, U., 18-Aug-2019, In : Clinical and Experimental Allergy. 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Milanzi, E. B., Koppelman, G. H., Smit, H. A., Wijga, A. H., Vonk, J. M., Brunekreef, B., & Gehring, U. (2019). Role of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence. Clinical and Experimental Allergy. https://doi.org/10.1111/cea.13471

Author

Milanzi, Edith B ; Koppelman, Gerard H ; Smit, Henriette A ; Wijga, Alet H ; Vonk, Judith M ; Brunekreef, Bert ; Gehring, Ulrike. / Role of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence. In: Clinical and Experimental Allergy. 2019.

Harvard

Milanzi, EB, Koppelman, GH, Smit, HA, Wijga, AH, Vonk, JM, Brunekreef, B & Gehring, U 2019, 'Role of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence', Clinical and Experimental Allergy. https://doi.org/10.1111/cea.13471

Standard

Role of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence. / Milanzi, Edith B; Koppelman, Gerard H; Smit, Henriette A; Wijga, Alet H; Vonk, Judith M; Brunekreef, Bert; Gehring, Ulrike.

In: Clinical and Experimental Allergy, 18.08.2019.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Milanzi EB, Koppelman GH, Smit HA, Wijga AH, Vonk JM, Brunekreef B et al. Role of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence. Clinical and Experimental Allergy. 2019 Aug 18. https://doi.org/10.1111/cea.13471


BibTeX

@article{dfa38cd176fb48dd8b689b41d2301520,
title = "Role of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence",
abstract = "BACKGROUND: Pet and dampness or mould exposure are considered risk factors for asthma and sensitization. It is unclear whether timing of exposure to these factors is differentially associated with asthma risk and sensitization in adolescence.OBJECTIVE: We investigated the role of timing of pet and dampness or mould exposure in asthma and sensitization in adolescence. Understanding this role is essential to build targeted prevention strategies.METHODS: We used data from 1871 participants of the Dutch Prevention and Incidence of Asthma and Mite Allergy (PIAMA) cohort. Residential exposure to pets, dampness or mould was assessed by repeated parental questionnaires. We used asthma data from the 17-year questionnaire and sensitization data from the 16-year medical examination. We characterized timing using longitudinal exposure patterns from pregnancy till age 17 using longitudinal latent class growth modelling. We used logistic regression models to analyse associations of exposure patterns with asthma at age 17 and sensitization at age 16.RESULTS: For none of the time windows, exposure to pets and dampness or mould was associated with asthma at age 17, but a lower sensitization risk at age 16 was suggested, for example the odds ratio (95% confidence interval) for sensitization was 0.63 (0.35-1.11) and 0.69 (0.44-1.08) for early life and persistently high pet exposure, respectively, compared with very low exposure. An inverse association was also suggested for sensitization and moderate early childhood dampness or mould exposure (0.71 [0.42-1.19]).CONCLUSION AND CLINICAL RELEVANCE: Different timing of pet and dampness or mould exposure was not associated with asthma, but lower risk of sensitization in adolescence was suggested, which could be partly attributable to reversed causation. Current findings are not sufficient to recommend pet avoidance to prevent allergic disease. More prospective studies are needed to obtain insights that can be used in clinical practice.",
keywords = "adolescence, asthma, dampness and mould, pets, sensitization, HAY-FEVER, ALLERGIC SENSITIZATION, RESPIRATORY HEALTH, FARMERS CHILDREN, ENDOTOXIN LEVELS, HOUSE-DUST, 1ST YEAR, BIRTH, RISK, CHILDHOOD",
author = "Milanzi, {Edith B} and Koppelman, {Gerard H} and Smit, {Henriette A} and Wijga, {Alet H} and Vonk, {Judith M} and Bert Brunekreef and Ulrike Gehring",
note = "{\textcopyright} 2019 John Wiley & Sons Ltd.",
year = "2019",
month = aug,
day = "18",
doi = "10.1111/cea.13471",
language = "English",
journal = "Clinical and Experimental Allergy",
issn = "0954-7894",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - Role of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence

AU - Milanzi, Edith B

AU - Koppelman, Gerard H

AU - Smit, Henriette A

AU - Wijga, Alet H

AU - Vonk, Judith M

AU - Brunekreef, Bert

AU - Gehring, Ulrike

N1 - © 2019 John Wiley & Sons Ltd.

PY - 2019/8/18

Y1 - 2019/8/18

N2 - BACKGROUND: Pet and dampness or mould exposure are considered risk factors for asthma and sensitization. It is unclear whether timing of exposure to these factors is differentially associated with asthma risk and sensitization in adolescence.OBJECTIVE: We investigated the role of timing of pet and dampness or mould exposure in asthma and sensitization in adolescence. Understanding this role is essential to build targeted prevention strategies.METHODS: We used data from 1871 participants of the Dutch Prevention and Incidence of Asthma and Mite Allergy (PIAMA) cohort. Residential exposure to pets, dampness or mould was assessed by repeated parental questionnaires. We used asthma data from the 17-year questionnaire and sensitization data from the 16-year medical examination. We characterized timing using longitudinal exposure patterns from pregnancy till age 17 using longitudinal latent class growth modelling. We used logistic regression models to analyse associations of exposure patterns with asthma at age 17 and sensitization at age 16.RESULTS: For none of the time windows, exposure to pets and dampness or mould was associated with asthma at age 17, but a lower sensitization risk at age 16 was suggested, for example the odds ratio (95% confidence interval) for sensitization was 0.63 (0.35-1.11) and 0.69 (0.44-1.08) for early life and persistently high pet exposure, respectively, compared with very low exposure. An inverse association was also suggested for sensitization and moderate early childhood dampness or mould exposure (0.71 [0.42-1.19]).CONCLUSION AND CLINICAL RELEVANCE: Different timing of pet and dampness or mould exposure was not associated with asthma, but lower risk of sensitization in adolescence was suggested, which could be partly attributable to reversed causation. Current findings are not sufficient to recommend pet avoidance to prevent allergic disease. More prospective studies are needed to obtain insights that can be used in clinical practice.

AB - BACKGROUND: Pet and dampness or mould exposure are considered risk factors for asthma and sensitization. It is unclear whether timing of exposure to these factors is differentially associated with asthma risk and sensitization in adolescence.OBJECTIVE: We investigated the role of timing of pet and dampness or mould exposure in asthma and sensitization in adolescence. Understanding this role is essential to build targeted prevention strategies.METHODS: We used data from 1871 participants of the Dutch Prevention and Incidence of Asthma and Mite Allergy (PIAMA) cohort. Residential exposure to pets, dampness or mould was assessed by repeated parental questionnaires. We used asthma data from the 17-year questionnaire and sensitization data from the 16-year medical examination. We characterized timing using longitudinal exposure patterns from pregnancy till age 17 using longitudinal latent class growth modelling. We used logistic regression models to analyse associations of exposure patterns with asthma at age 17 and sensitization at age 16.RESULTS: For none of the time windows, exposure to pets and dampness or mould was associated with asthma at age 17, but a lower sensitization risk at age 16 was suggested, for example the odds ratio (95% confidence interval) for sensitization was 0.63 (0.35-1.11) and 0.69 (0.44-1.08) for early life and persistently high pet exposure, respectively, compared with very low exposure. An inverse association was also suggested for sensitization and moderate early childhood dampness or mould exposure (0.71 [0.42-1.19]).CONCLUSION AND CLINICAL RELEVANCE: Different timing of pet and dampness or mould exposure was not associated with asthma, but lower risk of sensitization in adolescence was suggested, which could be partly attributable to reversed causation. Current findings are not sufficient to recommend pet avoidance to prevent allergic disease. More prospective studies are needed to obtain insights that can be used in clinical practice.

KW - adolescence

KW - asthma

KW - dampness and mould

KW - pets

KW - sensitization

KW - HAY-FEVER

KW - ALLERGIC SENSITIZATION

KW - RESPIRATORY HEALTH

KW - FARMERS CHILDREN

KW - ENDOTOXIN LEVELS

KW - HOUSE-DUST

KW - 1ST YEAR

KW - BIRTH

KW - RISK

KW - CHILDHOOD

U2 - 10.1111/cea.13471

DO - 10.1111/cea.13471

M3 - Article

C2 - 31336400

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

SN - 0954-7894

ER -

ID: 94891305