Publication

Role of oxidized low-density lipoprotein in renal disease

Heeringa, P. & Tervaert, JWC., May-2002, In : CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 11, 3, p. 287-293 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Accelerated atherosclerosis is often observed in patients with chronic renal failure. In the present review we summarize and discuss the recent literature on the pathogenic role of low-density lipoproteins modified by oxidative processes in atherosclerosis and the possible role in renal diseases. Pathogenetically, the oxidation of low-density lipoproteins is considered to be a key event in the development of atherosclerosis, in part by causing enhanced uptake of lipids by macrophages. In addition, oxidation of low-density lipoproteins exerts cytotoxic, proinflammatory and immunogenic properties, all of which could potentially contribute to the development and progression of atherosclerosis.

Original languageEnglish
Pages (from-to)287-293
Number of pages7
JournalCURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
Volume11
Issue number3
Publication statusPublished - May-2002

    Keywords

  • HYPOCHLORITE-MODIFIED PROTEINS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, NITRIC-OXIDE SYNTHASE, HUMAN ATHEROSCLEROTIC LESIONS, DEPENDENT DIABETES-MELLITUS, CORONARY-ARTERY DISEASE, SMOOTH-MUSCLE CELLS, APOE-DEFICIENT MICE, OXIDATIVE MODIFICATION, MESANGIAL CELLS

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