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Role of HDL cholesterol and estimates of HDL particle composition in future development of type 2 diabetes in the general population: the PREVEND study

Abbasi, A., Corpeleijn, E., Gansevoort, R. T., Gans, R. O. B., Hillege, H. L., Stolk, R. P., Navis, G., Bakker, S. J. L. & Dullaart, R. P. F., Aug-2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 8, p. E1352-E1359 8 p.

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Background and Aims: High-density lipoproteins (HDLs) may directly stimulate beta-cell function and glucose metabolism. We determined the relationships of fasting high-density lipoprotein cholesterol (HDL-C), plasma apolipoprotein (apo) A-I and apoA-II, and HDL-C-to-apoA-I and HDL-C-to-apoA-II ratios, as estimates of HDL particle composition, with incident type 2 diabetes mellitus.

Methods: A prospective study was carried out in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort after exclusion of subjects with diabetes at baseline (n = 6820; age, 28-75 years). The association of HDL-related variables with incident type 2 diabetes was determined by multivariate logistic regression analyses.

Results: After a median follow-up of 7.7 years, 394 incident cases of type 2 diabetes mellitus were ascertained (5.8%). After adjustment for age, sex, family history of diabetes, body mass index, hypertension, alcohol, and smoking, odd ratios (ORs) for diabetes were 0.55 (95% confidence interval [CI], 0.47-0.64; P <.001), 0.81 (0.71-0.93; P = .002), 0.02 (0.01-0.06; P <.001), and 0.03 (0.01-0.060; P <.001) per 1-SD increase in HDL-C and apoA-I and in the HDL-C-to-apoA-I and the HDL-C-to-apoA-II ratios, respectively. In contrast, apoA-II was not related to incident diabetes (OR = 1.02; 95% CI, 0.90-1.16; P=0.71). The relationships of HDL-C and the ratios of HDL-C to apoA-I and HDL-C to apoA-II remained significant after further adjustment for baseline glucose and triglycerides (ORHDL = 0.74 [95% CI, 0.61-0.88], ORHDL/APOA-I = 0.14 [0.04-0.44], and ORHDL/APOA-II = 0.12 [0.04-0.36]; all P

Conclusions: Higher HDL-C, as well as higher HDL-C-to-apoA-I and HDL-C-to-apoA-II ratios are strongly and independently related to a lower risk of future type 2 diabetes.

Original languageEnglish
Pages (from-to)E1352-E1359
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume98
Issue number8
Publication statusPublished - Aug-2013

    Keywords

  • HIGH-DENSITY-LIPOPROTEIN, BETA-CELL FUNCTION, APOLIPOPROTEIN-A-II, GLUCOSE-METABOLISM, INSULIN-RESISTANCE, RISK-FACTORS, MELLITUS, DISEASE, PREDICTION, ATHEROSCLEROSIS

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