Role of endothelial glycocalyx in sliding friction at the catheter-blood vessel interfaceLin, C., Kaper, H. J., Li, W., Splinter, R. & Sharma, P. K., 16-Jul-2020, In : Scientific Reports. 10, 1, 10 p., 11855.
Research output: Contribution to journal › Article › Academic › peer-review
Catheterization is a common medical operation to diagnose and treat cardiovascular diseases. The blood vessel lumen is coated with endothelial glycocalyx layer (EGL), which is important for the permeability and diffusion through the blood vessels wall, blood hemodynamics and mechanotransduction. However EGL's role in catheter-blood vessel friction is not explored. We use a porcine aorta to mimic the blood vessel and a catheter loop was made to rub in reciprocating sliding mode against it to understand the role of catheter loop curvature, stiffness, normal load, sliding speed and EGL on the friction properties. Trypsin treatment was used to cause a degradation of the EGL. Decrease in catheter loop stiffness and EGL degradation were the strongest factors which dramatically increased the coefficient of friction (COF) and frictional energy dissipation at the aorta-catheter interface. Increasing sliding speed caused an increase but increase in normal load first caused a decrease and then an increase in the COF and frictional energy. These results provide the basic data for safety of operation and damage control during catheterization in patients with degraded EGL.
|Number of pages||10|
|Publication status||Published - 16-Jul-2020|
- SMALL-INTESTINE, INJURY, COMPLICATIONS, INFLAMMATION, DEGRADATION, THICKNESS, BEHAVIOR, DENSITY, BARRIER, STRESS