Publication

Rodent models of social stress and neuronal plasticity: Relevance to depressive-like disorders

Patel, D., Kas, M. J., Chattarji, S. & Buwalda, B., Sep-2019, In : Behavioural Brain Research. 369, 111900.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Patel, D., Kas, M. J., Chattarji, S., & Buwalda, B. (2019). Rodent models of social stress and neuronal plasticity: Relevance to depressive-like disorders. Behavioural Brain Research, 369, [111900]. https://doi.org/10.1016/j.bbr.2019.111900

Author

Patel, Deepika ; Kas, Martien J ; Chattarji, Sumantra ; Buwalda, Bauke. / Rodent models of social stress and neuronal plasticity : Relevance to depressive-like disorders. In: Behavioural Brain Research. 2019 ; Vol. 369.

Harvard

Patel, D, Kas, MJ, Chattarji, S & Buwalda, B 2019, 'Rodent models of social stress and neuronal plasticity: Relevance to depressive-like disorders', Behavioural Brain Research, vol. 369, 111900. https://doi.org/10.1016/j.bbr.2019.111900

Standard

Rodent models of social stress and neuronal plasticity : Relevance to depressive-like disorders. / Patel, Deepika; Kas, Martien J; Chattarji, Sumantra; Buwalda, Bauke.

In: Behavioural Brain Research, Vol. 369, 111900, 09.2019.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Patel D, Kas MJ, Chattarji S, Buwalda B. Rodent models of social stress and neuronal plasticity: Relevance to depressive-like disorders. Behavioural Brain Research. 2019 Sep;369. 111900. https://doi.org/10.1016/j.bbr.2019.111900


BibTeX

@article{62628dbceaf04030930fd4090f2197d0,
title = "Rodent models of social stress and neuronal plasticity: Relevance to depressive-like disorders",
abstract = "Exposure to severe or persistent social stress may lead to the development of psychiatric disorders such as anxiety and depression. These mood disorders are associated with structural alterations of neural architecture in limbic brain regions that control emotion, mood and cognition. Structural remodeling may either be a sign of successful adaptation, or of failure to do so. In neuropsychiatric disorders like depression structural remodeling involves apoptosis, reduced neurogenesis, and structural remodeling of neuronal dendrites which most likely reflects the latter. Here we review key findings from animal models of psychosocial stress that have been used to gain insights into the relation between stress-related behavioral disorders like depression and structural plasticity. Specifically, we focus on models having a high face validity like social defeat stress in the resident-intruder paradigm and chronic stress of social subordination in social housing conditions. Moderate to severe social stress appears to stimulate plasticity and neuronal growth in regions of the amygdala, whereas the effects in the hippocampus and prefrontal cortex tend to be opposite. A major focus of the current review is to characterize social stress induced structural changes in these brain regions, aiming to provide insight in pathways and factors that underlie behavioral effects of stress and depression.",
keywords = "stress, neuronal plasticity, social, neuronal structure, Rodent, MEDIAL PREFRONTAL CORTEX, CHRONIC PSYCHOSOCIAL STRESS, TISSUE-PLASMINOGEN ACTIVATOR, VISIBLE BURROW SYSTEM, CA3 PYRAMIDAL NEURONS, HIPPOCAMPAL VOLUME, STRUCTURAL PLASTICITY, NEUROTROPHIC FACTOR, DENDRITIC SPINE, VENTRAL HIPPOCAMPUS",
author = "Deepika Patel and Kas, {Martien J} and Sumantra Chattarji and Bauke Buwalda",
year = "2019",
month = "9",
doi = "10.1016/j.bbr.2019.111900",
language = "English",
volume = "369",
journal = "Behavioral Brain Research",
issn = "0166-4328",
publisher = "ELSEVIER SCIENCE BV",

}

RIS

TY - JOUR

T1 - Rodent models of social stress and neuronal plasticity

T2 - Relevance to depressive-like disorders

AU - Patel, Deepika

AU - Kas, Martien J

AU - Chattarji, Sumantra

AU - Buwalda, Bauke

PY - 2019/9

Y1 - 2019/9

N2 - Exposure to severe or persistent social stress may lead to the development of psychiatric disorders such as anxiety and depression. These mood disorders are associated with structural alterations of neural architecture in limbic brain regions that control emotion, mood and cognition. Structural remodeling may either be a sign of successful adaptation, or of failure to do so. In neuropsychiatric disorders like depression structural remodeling involves apoptosis, reduced neurogenesis, and structural remodeling of neuronal dendrites which most likely reflects the latter. Here we review key findings from animal models of psychosocial stress that have been used to gain insights into the relation between stress-related behavioral disorders like depression and structural plasticity. Specifically, we focus on models having a high face validity like social defeat stress in the resident-intruder paradigm and chronic stress of social subordination in social housing conditions. Moderate to severe social stress appears to stimulate plasticity and neuronal growth in regions of the amygdala, whereas the effects in the hippocampus and prefrontal cortex tend to be opposite. A major focus of the current review is to characterize social stress induced structural changes in these brain regions, aiming to provide insight in pathways and factors that underlie behavioral effects of stress and depression.

AB - Exposure to severe or persistent social stress may lead to the development of psychiatric disorders such as anxiety and depression. These mood disorders are associated with structural alterations of neural architecture in limbic brain regions that control emotion, mood and cognition. Structural remodeling may either be a sign of successful adaptation, or of failure to do so. In neuropsychiatric disorders like depression structural remodeling involves apoptosis, reduced neurogenesis, and structural remodeling of neuronal dendrites which most likely reflects the latter. Here we review key findings from animal models of psychosocial stress that have been used to gain insights into the relation between stress-related behavioral disorders like depression and structural plasticity. Specifically, we focus on models having a high face validity like social defeat stress in the resident-intruder paradigm and chronic stress of social subordination in social housing conditions. Moderate to severe social stress appears to stimulate plasticity and neuronal growth in regions of the amygdala, whereas the effects in the hippocampus and prefrontal cortex tend to be opposite. A major focus of the current review is to characterize social stress induced structural changes in these brain regions, aiming to provide insight in pathways and factors that underlie behavioral effects of stress and depression.

KW - stress

KW - neuronal plasticity

KW - social

KW - neuronal structure

KW - Rodent

KW - MEDIAL PREFRONTAL CORTEX

KW - CHRONIC PSYCHOSOCIAL STRESS

KW - TISSUE-PLASMINOGEN ACTIVATOR

KW - VISIBLE BURROW SYSTEM

KW - CA3 PYRAMIDAL NEURONS

KW - HIPPOCAMPAL VOLUME

KW - STRUCTURAL PLASTICITY

KW - NEUROTROPHIC FACTOR

KW - DENDRITIC SPINE

KW - VENTRAL HIPPOCAMPUS

U2 - 10.1016/j.bbr.2019.111900

DO - 10.1016/j.bbr.2019.111900

M3 - Review article

VL - 369

JO - Behavioral Brain Research

JF - Behavioral Brain Research

SN - 0166-4328

M1 - 111900

ER -

ID: 80968513