RNA-quality control by the exosomeHouseley, J., LaCava, J. & Tollervey, D., Jul-2006, In : Nature Reviews Molecular Cell Biology. 7, 7, p. 529-539 11 p.
Research output: Contribution to journal › Review article › Academic › peer-review
The exosome complex of 3'-> 5' exonucleases is an important component of the RNA-processing machinery in eukaryotes. This complex functions in the accurate processing of nuclear RNA precursors and in the degradation of RNAs in both the nucleus and the cytoplasm. However, it has been unclear how different classes of substrate are distinguished from one another. Recent studies now provide insights into the regulation and structure of the exosome, and they reveal striking similarities between the process of RNA degradation in bacteria and eukaryotes.
|Number of pages||11|
|Journal||Nature Reviews Molecular Cell Biology|
|Publication status||Published - Jul-2006|
- POLYNUCLEOTIDE PHOSPHORYLASE FUNCTIONS, PROMOTES TRANSCRIPTION TERMINATION, 5.8S RIBOSOMAL-RNA, 3' END FORMATION, HUMAN PM-SCL, MESSENGER-RNA, SACCHAROMYCES-CEREVISIAE, POLY(A) POLYMERASE, NUCLEAR EXOSOME, BINDING PROTEIN