Publication

Risk of subarachnoid haemorrhage according to number of affected relatives: a population based case-control study

Bor, A. S. E., Rinkel, G. J. E., Adami, J., Koffijberg, H., Ekbom, A., Buskens, E., Blomqvist, P. & Granath, F., Oct-2008, In : Brain. 131, p. 2662-2665 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Bor, A. S. E., Rinkel, G. J. E., Adami, J., Koffijberg, H., Ekbom, A., Buskens, E., ... Granath, F. (2008). Risk of subarachnoid haemorrhage according to number of affected relatives: a population based case-control study. Brain, 131, 2662-2665. https://doi.org/10.1093/brain/awn187

Author

Bor, A. S. E. ; Rinkel, G. J. E. ; Adami, J. ; Koffijberg, H. ; Ekbom, A. ; Buskens, E. ; Blomqvist, P. ; Granath, F. / Risk of subarachnoid haemorrhage according to number of affected relatives : a population based case-control study. In: Brain. 2008 ; Vol. 131. pp. 2662-2665.

Harvard

Bor, ASE, Rinkel, GJE, Adami, J, Koffijberg, H, Ekbom, A, Buskens, E, Blomqvist, P & Granath, F 2008, 'Risk of subarachnoid haemorrhage according to number of affected relatives: a population based case-control study', Brain, vol. 131, pp. 2662-2665. https://doi.org/10.1093/brain/awn187

Standard

Risk of subarachnoid haemorrhage according to number of affected relatives : a population based case-control study. / Bor, A. S. E.; Rinkel, G. J. E.; Adami, J.; Koffijberg, H.; Ekbom, A.; Buskens, E.; Blomqvist, P.; Granath, F.

In: Brain, Vol. 131, 10.2008, p. 2662-2665.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Bor ASE, Rinkel GJE, Adami J, Koffijberg H, Ekbom A, Buskens E et al. Risk of subarachnoid haemorrhage according to number of affected relatives: a population based case-control study. Brain. 2008 Oct;131:2662-2665. https://doi.org/10.1093/brain/awn187


BibTeX

@article{84109d8e583c4160bd3718b6e48c7ea0,
title = "Risk of subarachnoid haemorrhage according to number of affected relatives: a population based case-control study",
abstract = "Relatives of patients with aneurysmal subarachnoid haemorrhage (SAH) have an increased risk of this type of stroke. In a population-based study, we analysed individualized risks of SAH according to the number of affected first-degree relatives. We retrieved all patients diagnosed with SAH in 2001-05 from the Swedish Inpatient Register. For each of the 5282 patients, we identified five controls (n = 26 402) through the nationwide Register of Total Population. Through the Multi-generation Register, we retrieved all first-degree relatives for patients and controls and checked whether these 130 373 relatives had been diagnosed with SAH. By means of conditional logistic regression, we calculated odds ratios with corresponding 95{\%} confidence intervals (95{\%} CI) for the risk of SAH according to the number of affected relatives, and to the gender, age and type of kinship of the patient and affected relative. The odds ratio of SAH for individuals with one affected first-degree relative was 2.15 (95{\%} CI 1.77-2.59). For individuals with two affected first-degree relatives, the odds ratio was 51.0 (95{\%} CI 8.56-1117). Gender, age and type of kinship did not influence the risk for individuals with one or more affected relatives. The risk of SAH is slightly increased in the cases with one, but strongly increased in cases with two or more affected first-degree relatives. The latter strongly increased risk corresponds to a considerable absolute life-time risk of SAH and underscores the need to consider screening for aneurysms in these individuals.",
keywords = "subarachnoid haemorrhage, aneurysms, population based, epidemiology, family study, CASE-FATALITY RATES, INTRACRANIAL ANEURYSMS, 1ST-DEGREE RELATIVES, SWEDEN, TRENDS, JAPAN",
author = "Bor, {A. S. E.} and Rinkel, {G. J. E.} and J. Adami and H. Koffijberg and A. Ekbom and E. Buskens and P. Blomqvist and F. Granath",
year = "2008",
month = "10",
doi = "10.1093/brain/awn187",
language = "English",
volume = "131",
pages = "2662--2665",
journal = "Brain",
issn = "0006-8950",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Risk of subarachnoid haemorrhage according to number of affected relatives

T2 - a population based case-control study

AU - Bor, A. S. E.

AU - Rinkel, G. J. E.

AU - Adami, J.

AU - Koffijberg, H.

AU - Ekbom, A.

AU - Buskens, E.

AU - Blomqvist, P.

AU - Granath, F.

PY - 2008/10

Y1 - 2008/10

N2 - Relatives of patients with aneurysmal subarachnoid haemorrhage (SAH) have an increased risk of this type of stroke. In a population-based study, we analysed individualized risks of SAH according to the number of affected first-degree relatives. We retrieved all patients diagnosed with SAH in 2001-05 from the Swedish Inpatient Register. For each of the 5282 patients, we identified five controls (n = 26 402) through the nationwide Register of Total Population. Through the Multi-generation Register, we retrieved all first-degree relatives for patients and controls and checked whether these 130 373 relatives had been diagnosed with SAH. By means of conditional logistic regression, we calculated odds ratios with corresponding 95% confidence intervals (95% CI) for the risk of SAH according to the number of affected relatives, and to the gender, age and type of kinship of the patient and affected relative. The odds ratio of SAH for individuals with one affected first-degree relative was 2.15 (95% CI 1.77-2.59). For individuals with two affected first-degree relatives, the odds ratio was 51.0 (95% CI 8.56-1117). Gender, age and type of kinship did not influence the risk for individuals with one or more affected relatives. The risk of SAH is slightly increased in the cases with one, but strongly increased in cases with two or more affected first-degree relatives. The latter strongly increased risk corresponds to a considerable absolute life-time risk of SAH and underscores the need to consider screening for aneurysms in these individuals.

AB - Relatives of patients with aneurysmal subarachnoid haemorrhage (SAH) have an increased risk of this type of stroke. In a population-based study, we analysed individualized risks of SAH according to the number of affected first-degree relatives. We retrieved all patients diagnosed with SAH in 2001-05 from the Swedish Inpatient Register. For each of the 5282 patients, we identified five controls (n = 26 402) through the nationwide Register of Total Population. Through the Multi-generation Register, we retrieved all first-degree relatives for patients and controls and checked whether these 130 373 relatives had been diagnosed with SAH. By means of conditional logistic regression, we calculated odds ratios with corresponding 95% confidence intervals (95% CI) for the risk of SAH according to the number of affected relatives, and to the gender, age and type of kinship of the patient and affected relative. The odds ratio of SAH for individuals with one affected first-degree relative was 2.15 (95% CI 1.77-2.59). For individuals with two affected first-degree relatives, the odds ratio was 51.0 (95% CI 8.56-1117). Gender, age and type of kinship did not influence the risk for individuals with one or more affected relatives. The risk of SAH is slightly increased in the cases with one, but strongly increased in cases with two or more affected first-degree relatives. The latter strongly increased risk corresponds to a considerable absolute life-time risk of SAH and underscores the need to consider screening for aneurysms in these individuals.

KW - subarachnoid haemorrhage

KW - aneurysms

KW - population based

KW - epidemiology

KW - family study

KW - CASE-FATALITY RATES

KW - INTRACRANIAL ANEURYSMS

KW - 1ST-DEGREE RELATIVES

KW - SWEDEN

KW - TRENDS

KW - JAPAN

U2 - 10.1093/brain/awn187

DO - 10.1093/brain/awn187

M3 - Article

VL - 131

SP - 2662

EP - 2665

JO - Brain

JF - Brain

SN - 0006-8950

ER -

ID: 4796178