Publication

Risk factors for refractory anastomotic strictures after oesophageal atresia repair: a multicentre study

Vergouwe, FWT., Vlot, J., Ijsselstijn, H., Spaander, M. C. W., van Rosmalen, J., Oomen, M. W. N., Hulscher, J. B. F., Dirix, M., Bruno, M. J., Schurink, M. & Wijnen, R. M. H., Jan-2019, In : Archives of Disease in Childhood. 104, 2, p. 152-157 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Vergouwe, FWT., Vlot, J., Ijsselstijn, H., Spaander, M. C. W., van Rosmalen, J., Oomen, M. W. N., ... Wijnen, R. M. H. (2019). Risk factors for refractory anastomotic strictures after oesophageal atresia repair: a multicentre study. Archives of Disease in Childhood, 104(2), 152-157. https://doi.org/10.1136/archdischild-2017-314710

Author

Vergouwe, FWT ; Vlot, J ; Ijsselstijn, Hanneke ; Spaander, Manon C. W. ; van Rosmalen, Joost ; Oomen, Matthijs W N ; Hulscher, Jan B.F. ; Dirix, Marc ; Bruno, Marco J. ; Schurink, Maarten ; Wijnen, Rene M. H. / Risk factors for refractory anastomotic strictures after oesophageal atresia repair : a multicentre study. In: Archives of Disease in Childhood. 2019 ; Vol. 104, No. 2. pp. 152-157.

Harvard

Vergouwe, FWT, Vlot, J, Ijsselstijn, H, Spaander, MCW, van Rosmalen, J, Oomen, MWN, Hulscher, JBF, Dirix, M, Bruno, MJ, Schurink, M & Wijnen, RMH 2019, 'Risk factors for refractory anastomotic strictures after oesophageal atresia repair: a multicentre study', Archives of Disease in Childhood, vol. 104, no. 2, pp. 152-157. https://doi.org/10.1136/archdischild-2017-314710

Standard

Risk factors for refractory anastomotic strictures after oesophageal atresia repair : a multicentre study. / Vergouwe, FWT; Vlot, J; Ijsselstijn, Hanneke; Spaander, Manon C. W.; van Rosmalen, Joost; Oomen, Matthijs W N; Hulscher, Jan B.F.; Dirix, Marc; Bruno, Marco J.; Schurink, Maarten; Wijnen, Rene M. H.

In: Archives of Disease in Childhood, Vol. 104, No. 2, 01.2019, p. 152-157.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Vergouwe FWT, Vlot J, Ijsselstijn H, Spaander MCW, van Rosmalen J, Oomen MWN et al. Risk factors for refractory anastomotic strictures after oesophageal atresia repair: a multicentre study. Archives of Disease in Childhood. 2019 Jan;104(2):152-157. https://doi.org/10.1136/archdischild-2017-314710


BibTeX

@article{83255b52361948e9bf8cd072c7b6af49,
title = "Risk factors for refractory anastomotic strictures after oesophageal atresia repair: a multicentre study",
abstract = "OBJECTIVE: To determine the incidence of refractory anastomotic strictures after oesophageal atresia (OA) repair and to identify risk factors associated with refractory strictures. METHODS: Retrospective national multicentre study in patients with OA born between 1999 and 2013. Exclusion criteria were isolated fistula, inability to obtain oesophageal continuity, death prior to discharge and follow-up <6 months. A refractory oesophageal stricture was defined as an anastomotic stricture requiring ≥5 dilations at maximally 4-week intervals. Risk factors for development of refractory anastomotic strictures after OA repair were identified with multivariable logistic regression analysis. RESULTS: We included 454 children (61{\%} male, 7{\%} isolated OA (Gross type A)). End-to-end anastomosis was performed in 436 (96{\%}) children. Anastomotic leakage occurred in 13{\%}. Fifty-eight per cent of children with an end-to-end anastomosis developed an anastomotic stricture, requiring a median of 3 (range 1-34) dilations. Refractory strictures were found in 32/436 (7{\%}) children and required a median of 10 (range 5-34) dilations. Isolated OA (OR 5.7; p=0.012), anastomotic leakage (OR 5.0; p=0.001) and the need for oesophageal dilation ≤28 days after anastomosis (OR 15.9; p<0.001) were risk factors for development of a refractory stricture. CONCLUSIONS: The incidence of refractory strictures of the end-to-end anastomosis in children treated for OA was 7{\%}. Risk factors were isolated OA, anastomotic leakage and the need for oesophageal dilation less than 1 month after OA repair.",
keywords = "oesophageal atresia, MORTALITY, ANOMALIES, PROTON PUMP INHIBITORS, TRACHEOESOPHAGEAL FISTULA, THORACOSCOPIC REPAIR, SURGICAL REPAIR, COMPLICATIONS, CHILDREN, MORBIDITY, FREQUENCY",
author = "FWT Vergouwe and J Vlot and Hanneke Ijsselstijn and Spaander, {Manon C. W.} and {van Rosmalen}, Joost and Oomen, {Matthijs W N} and Hulscher, {Jan B.F.} and Marc Dirix and Bruno, {Marco J.} and Maarten Schurink and Wijnen, {Rene M. H.}",
year = "2019",
month = "1",
doi = "10.1136/archdischild-2017-314710",
language = "English",
volume = "104",
pages = "152--157",
journal = "Archives of Disease in Childhood",
issn = "0003-9888",
publisher = "BMJ PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - Risk factors for refractory anastomotic strictures after oesophageal atresia repair

T2 - a multicentre study

AU - Vergouwe, FWT

AU - Vlot, J

AU - Ijsselstijn, Hanneke

AU - Spaander, Manon C. W.

AU - van Rosmalen, Joost

AU - Oomen, Matthijs W N

AU - Hulscher, Jan B.F.

AU - Dirix, Marc

AU - Bruno, Marco J.

AU - Schurink, Maarten

AU - Wijnen, Rene M. H.

PY - 2019/1

Y1 - 2019/1

N2 - OBJECTIVE: To determine the incidence of refractory anastomotic strictures after oesophageal atresia (OA) repair and to identify risk factors associated with refractory strictures. METHODS: Retrospective national multicentre study in patients with OA born between 1999 and 2013. Exclusion criteria were isolated fistula, inability to obtain oesophageal continuity, death prior to discharge and follow-up <6 months. A refractory oesophageal stricture was defined as an anastomotic stricture requiring ≥5 dilations at maximally 4-week intervals. Risk factors for development of refractory anastomotic strictures after OA repair were identified with multivariable logistic regression analysis. RESULTS: We included 454 children (61% male, 7% isolated OA (Gross type A)). End-to-end anastomosis was performed in 436 (96%) children. Anastomotic leakage occurred in 13%. Fifty-eight per cent of children with an end-to-end anastomosis developed an anastomotic stricture, requiring a median of 3 (range 1-34) dilations. Refractory strictures were found in 32/436 (7%) children and required a median of 10 (range 5-34) dilations. Isolated OA (OR 5.7; p=0.012), anastomotic leakage (OR 5.0; p=0.001) and the need for oesophageal dilation ≤28 days after anastomosis (OR 15.9; p<0.001) were risk factors for development of a refractory stricture. CONCLUSIONS: The incidence of refractory strictures of the end-to-end anastomosis in children treated for OA was 7%. Risk factors were isolated OA, anastomotic leakage and the need for oesophageal dilation less than 1 month after OA repair.

AB - OBJECTIVE: To determine the incidence of refractory anastomotic strictures after oesophageal atresia (OA) repair and to identify risk factors associated with refractory strictures. METHODS: Retrospective national multicentre study in patients with OA born between 1999 and 2013. Exclusion criteria were isolated fistula, inability to obtain oesophageal continuity, death prior to discharge and follow-up <6 months. A refractory oesophageal stricture was defined as an anastomotic stricture requiring ≥5 dilations at maximally 4-week intervals. Risk factors for development of refractory anastomotic strictures after OA repair were identified with multivariable logistic regression analysis. RESULTS: We included 454 children (61% male, 7% isolated OA (Gross type A)). End-to-end anastomosis was performed in 436 (96%) children. Anastomotic leakage occurred in 13%. Fifty-eight per cent of children with an end-to-end anastomosis developed an anastomotic stricture, requiring a median of 3 (range 1-34) dilations. Refractory strictures were found in 32/436 (7%) children and required a median of 10 (range 5-34) dilations. Isolated OA (OR 5.7; p=0.012), anastomotic leakage (OR 5.0; p=0.001) and the need for oesophageal dilation ≤28 days after anastomosis (OR 15.9; p<0.001) were risk factors for development of a refractory stricture. CONCLUSIONS: The incidence of refractory strictures of the end-to-end anastomosis in children treated for OA was 7%. Risk factors were isolated OA, anastomotic leakage and the need for oesophageal dilation less than 1 month after OA repair.

KW - oesophageal atresia

KW - MORTALITY

KW - ANOMALIES

KW - PROTON PUMP INHIBITORS

KW - TRACHEOESOPHAGEAL FISTULA

KW - THORACOSCOPIC REPAIR

KW - SURGICAL REPAIR

KW - COMPLICATIONS

KW - CHILDREN

KW - MORBIDITY

KW - FREQUENCY

U2 - 10.1136/archdischild-2017-314710

DO - 10.1136/archdischild-2017-314710

M3 - Article

VL - 104

SP - 152

EP - 157

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

SN - 0003-9888

IS - 2

ER -

ID: 77588040