Publication

Reviving the protein quality control system: Therapeutic target for cardiac disease in the elderly

Meijering, R. A. M., Henning, R. H. & Brundel, B. J. J. M., Apr-2015, In : TRENDS IN CARDIOVASCULAR MEDICINE. 25, 3, p. 243-247 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Reviving the protein quality control system Therapeutic target for cardiac disease

    Final publisher's version, 554 KB, PDF document

    Request copy

DOI

It has been firmly established that ageing constitutes a principal risk factor for cardiac disease. Currently, the underlying mechanisms of ageing that contribute to the initiation or acceleration of cardiac disease are essentially unresolved. Prevailing theories of ageing center on the loss of cellular protein homeostasis, by either design (genetically) or "wear and tear" (environmentally). Either or both ways, the normal protein homeostasis in the cell is affected, resulting in aberrant and misfolded proteins. Should such misfolded proteins escape the protein quality control (PQC) system, they become proteotoxic and accelerate the loss of cellular integrity. Impairment of PQC plays a prominent role in the pathophysiology of ageing-related neurodegenerative disorders such as Parkinson's, Huntington׳s, and Alzheimer׳s disease. The concept of an impaired PQC driving ageing-related diseases has recently been expanded to cardiac diseases, including atrial fibrillation, cardiac hypertrophy, and cardiomyopathy. In this review, we provide a brief overview of the PQC system in relation to ageing and discuss the emerging concept of the loss of PQC in cardiomyocytes as a trigger for cardiac disease. Finally, we discuss the potential of boosting the PQC system as an innovative therapeutic target to treat cardiac disease in the elderly.

Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalTRENDS IN CARDIOVASCULAR MEDICINE
Volume25
Issue number3
Publication statusPublished - Apr-2015

    Keywords

  • DESMIN-RELATED CARDIOMYOPATHY, ENDOPLASMIC-RETICULUM STRESS, HEAT-SHOCK FACTOR, ATRIAL-FIBRILLATION, LIFE-SPAN, DROSOPHILA-MELANOGASTER, CAENORHABDITIS-ELEGANS, CHAPERONE NETWORKS, AUTOPHAGY, PROTEOSTASIS

View graph of relations

ID: 15331509