Publication

Reversal of pathophysiologic changes with long-term lisinopril treatment in isolated systolic hypertension

Heesen, WF., Beltman, FW., Smith, AJ., May, JF., de Graeff, PA., Muntinga, JHJ., Havinga, TK., Schuurman, FH., van der Veur, E., Meyboom-de Jong, B. & Lie, KI., May-2001, In : Journal of Cardiovascular Pharmacology. 37, 5, p. 512-521 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

The purpose of this study was to evaluate in a prospective, double-blind, placebo-controlled study the effect of long-term (2-year) lisinopril treatment on cardiovascular end-organ damage in patients with previously untreated isolated systolic hypertension (ISH). All patients with ISH were derived from a population screening program. End-organ damage measurements, done initially and after 6 and 24 months of treatment, included measurements of aortic distensibility and echocardiographic left ventricular mass index (LVMI) and diastolic function. Blood pressure was measured by office and ambulatory measurements. Of the 97 subjects with ISH selected from the screening, 62 (30 lisinopril) completed the study according to protocol. Office blood pressure decreased in both groups, but ambulatory results significantly decreased with lisinopril-treatment only. Aortic distensibility increased significantly with lisinopril, as opposed to a decrease in placebo-treated subjects. The main effect of increased distensibility occurred between 6 and 24 months, whereas ambulatory blood pressure changed mainly in the first 6 months of treatment. LVMI decreased in both treatment groups, with a significantly higher reduction in lisinopril-treated subjects. Left ventricular diastolic function showed no significant changes in either group. The vascular pathophysiologic alterations of ISH-a decreased aortic distensibility-can be improved with long-term lisinopril treatment, whereas values deteriorate further in placebo-treated subjects. These results, in one of the first studies including subjects with previously untreated ISH only, indicate that lisinopril treatment might favorably influence the cardiovascular risk of ISH.

Original languageEnglish
Pages (from-to)512-521
Number of pages10
JournalJournal of Cardiovascular Pharmacology
Volume37
Issue number5
Publication statusPublished - May-2001

    Keywords

  • hypertension, systolic, drug treatment, echocardiography, hypertrophy, vascular, pathophysiology, LEFT-VENTRICULAR MASS, ANTIHYPERTENSIVE TREATMENT, CARDIAC-HYPERTROPHY, MILD HYPERTENSION, ANATOMIC VALIDATION, WALL HYPERTROPHY, ELDERLY PATIENTS, OLDER PATIENTS, REGRESSION, PRESSURE

ID: 3934939