Reply to Letter to the Editor HEP-20-0593Roscam Abbing, R. L. P., Kuipers, F., Paulusma, C. C., Verkade, H. J., Groen, A. K., Oude Elferink, R. P. J., van, S. F. J. & de Graaf, I. M., 25-Apr-2020, In : Hepatology.
Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
We sincerely thank Dr. Javitt for his interest in and perspective on our paper (1). He indicates that aspecific effects of Myrcludex B should be considered an explanation for increased biliary cholesterol and phospholipid secretion after Myrcludex B treatment as partial hepatectomy (PH) also leads to an increased contribution of pericentral hepatocytes to bile salt uptake and secretion but biliary cholesterol and phospholipid secretion are not affected. In our opinion, non-specific Myrcludex B-induced activation of canalicular or sinusoidal transporters seems unlikely given the absence of NTCP homology with these transporters and our data from experiments with SR-B1 or ABCG8 null mice. Myrcludex B is an NTCP-specific peptide showing minimal uptake by hepatocytes.