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Renal hyperfiltration defined by high estimated glomerular filtration rate: A risk factor for cardiovascular disease and mortality

Kanbay, M., Ertuglu, L. A., Afsar, B., Ozdogan, E., Kucuksumer, Z. S., Ortiz, A., Covic, A., Kuwabara, M., Cherney, D. Z. I., van Raalte, D. H. & de Zeeuw, D., 12-Jul-2019, In : Diabetes obesity & metabolism. 16 p.

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  • Renal hyperfiltration defined by high estimated glomerular filtration rate

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DOI

  • Mehmet Kanbay
  • Lale A. Ertuglu
  • Baris Afsar
  • Elif Ozdogan
  • Zeynep S. Kucuksumer
  • Alberto Ortiz
  • Adrian Covic
  • Masanari Kuwabara
  • David Z. I. Cherney
  • Daniel H. van Raalte
  • Dick de Zeeuw

Renal hyperfiltration, defined as an increased glomerular filtration rate above normal values, is associated with early phases of kidney disease in the setting of various conditions such as obesity and diabetes. Although it is recognized that glomerular hyperfiltration, that is, increased filtration per nephron unit (usually studied at low glomerular filtration levels and often referred to as single nephron hyperfiltration), is a risk factor for the progression of chronic kidney disease, the implications of having renal hyperfiltration for cardiovascular disease and mortality risk are incompletely understood. Recent evidence from diverse populations, including healthy individuals and patients with diabetes or established cardiovascular disease, suggests that renal hyperfiltration is associated with a higher risk of cardiovascular disease and all-cause mortality. In this review, we critically summarize the existing studies, discuss possible mechanisms, and describe the remaining gaps in our knowledge regarding the association of renal hyperfiltration with cardiovascular disease and mortality risk.

Original languageEnglish
Number of pages16
JournalDiabetes obesity & metabolism
Publication statusE-pub ahead of print - 12-Jul-2019

    Keywords

  • cardiovascular disease, cardiovascular mortality, diabetes, glomerular hyperfiltration, renal hyperfiltration, CHRONIC KIDNEY-DISEASE, AMBULATORY BLOOD-PRESSURE, ALL-CAUSE MORTALITY, ATHEROSCLEROSIS RISK, ARTERIAL STIFFNESS, INSULIN-RESISTANCE, STAGE, ASSOCIATION, MECHANISMS, OBESITY

ID: 96881422