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Relationship Between Physical Frailty and Low-Grade Inflammation in Late-Life Depression

Arts, M. H. L., Collard, R. M., Comijs, H. C., Naude, P. J. W., Risselada, R., Naarding, P. & Oude Voshaar, R., Aug-2015, In : Journal of the American Geriatrics Society. 63, 8, p. 1652-1657 6 p.

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  • Relationship Between Physical Frailty and Low-Grade Inflammation in Late-Life Depression

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DOI

ObjectivesTo determine whether physical frailty is associated with low-grade inflammation in older adults with depression, because late-life depression is associated with physical frailty and low-grade inflammation.

DesignBaseline data of a cohort study.

SettingPrimary care and specialized mental health care.

ParticipantsIndividuals aged 60 and older with depression according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria (N=366).

MeasurementsThe physical frailty phenotype, defined as three out of five criteria (weight loss, weakness, exhaustion, slowness, low physical activity level), and three inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6), and neutrophil gelatinase-associated lipocalin (NGAL)) were assessed.

ResultsThe physical frailty phenotype was not associated with inflammatory markers in linear regression models adjusted for sociodemographic characteristics, lifestyle characteristics, and somatic morbidity. Of the individual criteria, handgrip strength was associated with CRP (=-0.21, P=.002) and IL-6 (=-0.25, P

ConclusionThe physical frailty phenotype is not a unidimensional construct in individuals with depression. Only performance-based physical frailty is associated with low-grade inflammation in late-life depression, which might point to a specific depressive subtype.

Original languageEnglish
Pages (from-to)1652-1657
Number of pages6
JournalJournal of the American Geriatrics Society
Volume63
Issue number8
Publication statusPublished - Aug-2015

    Keywords

  • frailty, depressive disorder, inflammation, C-reactive protein, interleukin-6, lipocalin-2, neutrophil gelatinase-associated lipocalin, GELATINASE-ASSOCIATED LIPOCALIN, MAJOR DEPRESSION, CYTOKINES, RELIABILITY, ADULTS, HEALTH

ID: 28342821