Publication

Relationship between drug burden and physical and cognitive functions in a sample of nursing home patients with dementia

Sanders, L. M. J., Hortobágyi, T., van Staveren, G., Taxis, K., Boersma, F., Klein, H. C., Bossers, W. J. R., Blankevoort, C. G., Scherder, E. J. A., van der Zee, E. A. & van Heuvelen, M. J. G., Dec-2017, In : European Journal of Clinical Pharmacology. 73, 12, p. 1633-1642 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Sanders, L. M. J., Hortobágyi, T., van Staveren, G., Taxis, K., Boersma, F., Klein, H. C., ... van Heuvelen, M. J. G. (2017). Relationship between drug burden and physical and cognitive functions in a sample of nursing home patients with dementia. European Journal of Clinical Pharmacology, 73(12), 1633-1642. https://doi.org/10.1007/s00228-017-2319-y

Author

Sanders, L. M. J. ; Hortobágyi, T. ; van Staveren, G. ; Taxis, K. ; Boersma, F. ; Klein, H. C. ; Bossers, W. J. R. ; Blankevoort, C. G. ; Scherder, E. J. A. ; van der Zee, E. A. ; van Heuvelen, M. J. G. / Relationship between drug burden and physical and cognitive functions in a sample of nursing home patients with dementia. In: European Journal of Clinical Pharmacology. 2017 ; Vol. 73, No. 12. pp. 1633-1642.

Harvard

Sanders, LMJ, Hortobágyi, T, van Staveren, G, Taxis, K, Boersma, F, Klein, HC, Bossers, WJR, Blankevoort, CG, Scherder, EJA, van der Zee, EA & van Heuvelen, MJG 2017, 'Relationship between drug burden and physical and cognitive functions in a sample of nursing home patients with dementia', European Journal of Clinical Pharmacology, vol. 73, no. 12, pp. 1633-1642. https://doi.org/10.1007/s00228-017-2319-y

Standard

Relationship between drug burden and physical and cognitive functions in a sample of nursing home patients with dementia. / Sanders, L. M. J.; Hortobágyi, T.; van Staveren, G.; Taxis, K.; Boersma, F.; Klein, H. C.; Bossers, W. J. R.; Blankevoort, C. G.; Scherder, E. J. A.; van der Zee, E. A.; van Heuvelen, M. J. G.

In: European Journal of Clinical Pharmacology, Vol. 73, No. 12, 12.2017, p. 1633-1642.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Sanders LMJ, Hortobágyi T, van Staveren G, Taxis K, Boersma F, Klein HC et al. Relationship between drug burden and physical and cognitive functions in a sample of nursing home patients with dementia. European Journal of Clinical Pharmacology. 2017 Dec;73(12):1633-1642. https://doi.org/10.1007/s00228-017-2319-y


BibTeX

@article{3b8e3f1da124451b942134b2708e4b1f,
title = "Relationship between drug burden and physical and cognitive functions in a sample of nursing home patients with dementia",
abstract = "Purpose: The Drug Burden Index (DBI) is a tool to quantify the anticholinergic and sedative load of drugs. Establishing functional correlates of the DBI could optimize drug prescribing in patients with dementia. In this cross-sectional study, we determined the relationship between DBI and cognitive and physical functions in a sample of patients with dementMethods: ia.Using performance-based tests, we measured physical and cognitive functions in 140 nursing home patients aged over 70 with all-cause dementia. We also determined anticholinergic DBI (AChDBI) and sedative DBI (SDBI) separately and in combination as total drug burden (TDB).Results: Nearly one half of patients (48{\%}) used at least one DBI-contributing drug. In 33{\%} of the patients, drug burden was moderate (0 <TDB <1) whereas in 15{\%}, drug burden was high (TDB ae 1). Multivariate models yielded no associations between TDB, AChDBI, and SDBI, and physical or cognitive function (all p > 0.05).Conclusions: A lack of association between drug burden and physical or cognitive function in this sample of patients with dementia could imply that drug prescribing is more optimal for patients with dementia compared with healthy older populations. However, such an interpretation of the data warrants scrutiny as several dementia-related factors may confound the results of the study.",
keywords = "Drug Burden Index, Dementia, Inappropriate prescribing, Nursing home facilities, Medication, INAPPROPRIATE MEDICATION USE, DWELLING OLDER-PEOPLE, RESIDENTIAL AGED CARE, ANTICHOLINERGIC BURDEN, PROSPECTIVE COHORT, AUSTRALIAN MEN, INDEX, ADULTS, POLYPHARMACY, OUTCOMES",
author = "Sanders, {L. M. J.} and T. Hortob{\'a}gyi and {van Staveren}, G. and K. Taxis and F. Boersma and Klein, {H. C.} and Bossers, {W. J. R.} and Blankevoort, {C. G.} and Scherder, {E. J. A.} and {van der Zee}, {E. A.} and {van Heuvelen}, {M. J. G.}",
year = "2017",
month = "12",
doi = "10.1007/s00228-017-2319-y",
language = "English",
volume = "73",
pages = "1633--1642",
journal = "European Journal of Clinical Pharmacology",
issn = "0031-6970",
publisher = "Springer Verlag",
number = "12",

}

RIS

TY - JOUR

T1 - Relationship between drug burden and physical and cognitive functions in a sample of nursing home patients with dementia

AU - Sanders, L. M. J.

AU - Hortobágyi, T.

AU - van Staveren, G.

AU - Taxis, K.

AU - Boersma, F.

AU - Klein, H. C.

AU - Bossers, W. J. R.

AU - Blankevoort, C. G.

AU - Scherder, E. J. A.

AU - van der Zee, E. A.

AU - van Heuvelen, M. J. G.

PY - 2017/12

Y1 - 2017/12

N2 - Purpose: The Drug Burden Index (DBI) is a tool to quantify the anticholinergic and sedative load of drugs. Establishing functional correlates of the DBI could optimize drug prescribing in patients with dementia. In this cross-sectional study, we determined the relationship between DBI and cognitive and physical functions in a sample of patients with dementMethods: ia.Using performance-based tests, we measured physical and cognitive functions in 140 nursing home patients aged over 70 with all-cause dementia. We also determined anticholinergic DBI (AChDBI) and sedative DBI (SDBI) separately and in combination as total drug burden (TDB).Results: Nearly one half of patients (48%) used at least one DBI-contributing drug. In 33% of the patients, drug burden was moderate (0 <TDB <1) whereas in 15%, drug burden was high (TDB ae 1). Multivariate models yielded no associations between TDB, AChDBI, and SDBI, and physical or cognitive function (all p > 0.05).Conclusions: A lack of association between drug burden and physical or cognitive function in this sample of patients with dementia could imply that drug prescribing is more optimal for patients with dementia compared with healthy older populations. However, such an interpretation of the data warrants scrutiny as several dementia-related factors may confound the results of the study.

AB - Purpose: The Drug Burden Index (DBI) is a tool to quantify the anticholinergic and sedative load of drugs. Establishing functional correlates of the DBI could optimize drug prescribing in patients with dementia. In this cross-sectional study, we determined the relationship between DBI and cognitive and physical functions in a sample of patients with dementMethods: ia.Using performance-based tests, we measured physical and cognitive functions in 140 nursing home patients aged over 70 with all-cause dementia. We also determined anticholinergic DBI (AChDBI) and sedative DBI (SDBI) separately and in combination as total drug burden (TDB).Results: Nearly one half of patients (48%) used at least one DBI-contributing drug. In 33% of the patients, drug burden was moderate (0 <TDB <1) whereas in 15%, drug burden was high (TDB ae 1). Multivariate models yielded no associations between TDB, AChDBI, and SDBI, and physical or cognitive function (all p > 0.05).Conclusions: A lack of association between drug burden and physical or cognitive function in this sample of patients with dementia could imply that drug prescribing is more optimal for patients with dementia compared with healthy older populations. However, such an interpretation of the data warrants scrutiny as several dementia-related factors may confound the results of the study.

KW - Drug Burden Index

KW - Dementia

KW - Inappropriate prescribing

KW - Nursing home facilities

KW - Medication

KW - INAPPROPRIATE MEDICATION USE

KW - DWELLING OLDER-PEOPLE

KW - RESIDENTIAL AGED CARE

KW - ANTICHOLINERGIC BURDEN

KW - PROSPECTIVE COHORT

KW - AUSTRALIAN MEN

KW - INDEX

KW - ADULTS

KW - POLYPHARMACY

KW - OUTCOMES

U2 - 10.1007/s00228-017-2319-y

DO - 10.1007/s00228-017-2319-y

M3 - Article

VL - 73

SP - 1633

EP - 1642

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

SN - 0031-6970

IS - 12

ER -

ID: 48036203