Publication

Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions

Soto-Gamez, A., Quax, W. J. & Demaria, M., 31-May-2019, In : Journal of Molecular Biology. 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Cellular senescence is a state of stable cell cycle arrest arising in response to DNA and mitochondrial damages. Senescent cells undergo morphological, structural and functional changes which are influenced by a number of variables, including time, stress, tissue, and cell type. The heterogeneity of the senescent phenotype is exemplified by the many biological properties that senescent cells can cover. The advent of innovative model organisms has demonstrated a functional role of senescent cells during embryogenesis, tissue remodeling, tumorigenesis and aging. Importantly, prolonged and aberrant persistence of senescent cells is often associated with tissue dysfunction and pathology, and partially the consequence of mechanisms that enhance survival and resistance to cell death. Here, we describe the main molecular players involved in promoting survival of senescent cells, with particular emphasis on the regulation of senescence-associated anti-apoptotic pathways. We discuss the consequences these pathways have in providing resistance to intrinsic and extrinsic pro-apoptotic signals. Finally, we highlight the importance of these pathways in the development of targets for senolytic interventions.

Original languageEnglish
Number of pages15
JournalJournal of Molecular Biology
Publication statusE-pub ahead of print - 31-May-2019

    Keywords

  • aging, apoptosis, cell death, cellular senescence, cancer survival, carcinogenesis, cell aging, embryo development, human, review

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ID: 84792415