Publication

Regulation of Microglia Identity from an Epigenetic and Transcriptomic Point of View

Eggen, B. J. L., Boddeke, E. W. G. M. & Kooistra, S. M., 1-May-2019, In : Neuroscience. 405, p. 3-13 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Eggen, B. J. L., Boddeke, E. W. G. M., & Kooistra, S. M. (2019). Regulation of Microglia Identity from an Epigenetic and Transcriptomic Point of View. Neuroscience, 405, 3-13. https://doi.org/10.1016/j.neuroscience.2017.12.010

Author

Eggen, Bart J L ; Boddeke, Erik W G M ; Kooistra, Susanne M. / Regulation of Microglia Identity from an Epigenetic and Transcriptomic Point of View. In: Neuroscience. 2019 ; Vol. 405. pp. 3-13.

Harvard

Eggen, BJL, Boddeke, EWGM & Kooistra, SM 2019, 'Regulation of Microglia Identity from an Epigenetic and Transcriptomic Point of View', Neuroscience, vol. 405, pp. 3-13. https://doi.org/10.1016/j.neuroscience.2017.12.010

Standard

Regulation of Microglia Identity from an Epigenetic and Transcriptomic Point of View. / Eggen, Bart J L; Boddeke, Erik W G M; Kooistra, Susanne M.

In: Neuroscience, Vol. 405, 01.05.2019, p. 3-13.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Eggen BJL, Boddeke EWGM, Kooistra SM. Regulation of Microglia Identity from an Epigenetic and Transcriptomic Point of View. Neuroscience. 2019 May 1;405:3-13. https://doi.org/10.1016/j.neuroscience.2017.12.010


BibTeX

@article{01f58745265941a6851153f9a4976f99,
title = "Regulation of Microglia Identity from an Epigenetic and Transcriptomic Point of View",
abstract = "Microglia have long been recognized as the endogenous innate immune elements in the central nervous system (CNS) parenchyma. Besides fulfilling local immune-related functions, they provide cross-talk between the CNS and the immune system at large. In the adult CNS, microglia are involved in maintaining brain homeostasis, modulating synaptic transmission and clearance of apoptotic cells. During embryonic development, microglia are responsible for the removal of supernumerary synapses and neurons, and neuronal network formation. The full scale of their potential abilities has been highlighted by improvements in microglia isolation methods, the development of genetically tagged mouse models, advanced imaging technologies and the application of next-generation sequencing in recent years. Genome-wide expression analysis of relatively pure microglia populations from both mouse and human CNS tissues has thereby greatly contributed to our knowledge of their biology; what defines them under homeostatic conditions and how microglia respond to processes like aging and CNS disease? How and to what degree beneficial functions of microglia can be restored in the aged or diseased brain will be the key issue to be addressed in future research.",
author = "Eggen, {Bart J L} and Boddeke, {Erik W G M} and Kooistra, {Susanne M}",
note = "Copyright {\circledC} 2017 IBRO. Published by Elsevier Ltd. All rights reserved.",
year = "2019",
month = "5",
day = "1",
doi = "10.1016/j.neuroscience.2017.12.010",
language = "English",
volume = "405",
pages = "3--13",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - Regulation of Microglia Identity from an Epigenetic and Transcriptomic Point of View

AU - Eggen, Bart J L

AU - Boddeke, Erik W G M

AU - Kooistra, Susanne M

N1 - Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Microglia have long been recognized as the endogenous innate immune elements in the central nervous system (CNS) parenchyma. Besides fulfilling local immune-related functions, they provide cross-talk between the CNS and the immune system at large. In the adult CNS, microglia are involved in maintaining brain homeostasis, modulating synaptic transmission and clearance of apoptotic cells. During embryonic development, microglia are responsible for the removal of supernumerary synapses and neurons, and neuronal network formation. The full scale of their potential abilities has been highlighted by improvements in microglia isolation methods, the development of genetically tagged mouse models, advanced imaging technologies and the application of next-generation sequencing in recent years. Genome-wide expression analysis of relatively pure microglia populations from both mouse and human CNS tissues has thereby greatly contributed to our knowledge of their biology; what defines them under homeostatic conditions and how microglia respond to processes like aging and CNS disease? How and to what degree beneficial functions of microglia can be restored in the aged or diseased brain will be the key issue to be addressed in future research.

AB - Microglia have long been recognized as the endogenous innate immune elements in the central nervous system (CNS) parenchyma. Besides fulfilling local immune-related functions, they provide cross-talk between the CNS and the immune system at large. In the adult CNS, microglia are involved in maintaining brain homeostasis, modulating synaptic transmission and clearance of apoptotic cells. During embryonic development, microglia are responsible for the removal of supernumerary synapses and neurons, and neuronal network formation. The full scale of their potential abilities has been highlighted by improvements in microglia isolation methods, the development of genetically tagged mouse models, advanced imaging technologies and the application of next-generation sequencing in recent years. Genome-wide expression analysis of relatively pure microglia populations from both mouse and human CNS tissues has thereby greatly contributed to our knowledge of their biology; what defines them under homeostatic conditions and how microglia respond to processes like aging and CNS disease? How and to what degree beneficial functions of microglia can be restored in the aged or diseased brain will be the key issue to be addressed in future research.

U2 - 10.1016/j.neuroscience.2017.12.010

DO - 10.1016/j.neuroscience.2017.12.010

M3 - Review article

VL - 405

SP - 3

EP - 13

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -

ID: 76749319