Publication

Regional distribution of slow-twitch muscle fibers after reinnervation in adult rat hindlimb muscles

Wang, LC., Copray, S., Brouwer, N., Meek, MF. & Kernell, D., Jun-2002, In : MUSCLE & NERVE. 25, 6, p. 805-815 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

the knee. Following a survival time of 21 weeks, five muscles were removed from both lower hindlimbs after determining their intra-limb positions. In each muscle, cryostat sections from seven equidistant proximo-distal levels were stained for myofibrillar ATPase. Intramuscular positions were determined for all slow-twitch type I fibers. Within each muscle, type I fibers were heterogeneously distributed, and the direction of type I fiber accumulation was, on average, almost identical in reinnervated muscles and contralateral controls. Furthermore, as in controls, a proximo-distal decline of type I fiber density was found in reinnervated muscles. Compared to contralateral controls, reinnervated muscles consistently showed a very high number of type I fibers at close interfiber distances, indicating respecification of muscle fiber types by the ingrowing nerve fibers. The results suggest that slow-twitch motor axons preferentially grew back toward the original slow-twitch muscle regions. (C) 2002 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)805-815
Number of pages11
JournalMUSCLE & NERVE
Volume25
Issue number6
Publication statusPublished - Jun-2002
Event29th Annual Meeting of the Society-for-Neuroscience -
Duration: 23-Oct-199928-Oct-1999

Event

29th Annual Meeting of the Society-for-Neuroscience

23/10/199928/10/1999

Event: Other

    Keywords

  • muscle fiber type grouping, rat, reinnervation, skeletal muscle, slow-twitch muscle fibers, topographical organization, CAT TIBIALIS ANTERIOR, INCOMPLETE NEURAL-CONTROL, MOTOR-UNIT PROPERTIES, SELECTIVE REINNERVATION, LATERAL GASTROCNEMIUS, SELF-REINNERVATION, SKELETAL-MUSCLES, THYROID-HORMONE, SOLEUS MUSCLES, NERVE REPAIR

ID: 4019960