Reducing dietary intake of linoleic acid of mouse dams during lactation increases offspring brain n-3 LCPUFA content

Schipper, L., Oosting, A., Scheurink, A. J. W., van Dijk, G. & van der Beek, E. M., Jul-2016, In : Prostaglandins Leukotrienes and Essential Fatty Acids. 110, p. 8-15 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard


  • Reducing dietary intake of linoleic acid of mouse dams during lactation

    Final publisher's version, 314 KB, PDF document

    Request copy


Omega (n-)3 and n-6 long chain polyunsaturated fatty acids (LCPUFA) accumulation in the infant brain after birth is strongly driven by dietary supply of n-3 and n-6 LCPUFAs and their C18 precursors through breast milk or infant formula. n-3 LCPUFA accretion is associated with positive effects on neurodevelopmental outcome whereas high n-6 LCPUFA accumulation is considered disadvantageous. Maternal diet is crucial for breast milk fatty acid composition. Unfortunately, global increases in linoleic acid (C18:2n-6; LA) intake have dramatically increased n-6 LCPUFA and reduced n-3 LCPUFA availability for breastfed infants. We investigated the effects of reducing maternal dietary LA, or increasing n-3 LCPUFA, during lactation on milk and offspring brain fatty acids in mice. Offspring brain n-3 LCPUFA was higher following both interventions, although effects were mediated by different mechanisms. Because of competitive interactions between n-3 and n-6 fatty acids, lowering maternal LA intake may support neurodevelopment in breastfed infants. (C) 2016 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Publication statusPublished - Jul-2016


  • Linoleic acid, n-3 Long chain polyunsaturated fatty acids, Maternal diet, Milk, Brain development, POLYUNSATURATED FATTY-ACIDS, DOCOSAHEXAENOIC ACID, HUMAN-MILK, BREAST-MILK, DEVELOPING RAT, MATERNAL DIET, FED INFANTS, YOUNG-RATS, OLEIC-ACID, CHAIN

ID: 37011941