Publication

Reduced astrocyte density underlying brain volume reduction inactivity-based anorexia rats

Frintrop, L., Liesbrock, J., Paulukat, L., Johann, S., Kas, M. J., Tolba, R., Heussen, N., Neulen, J., Konrad, K., Herpertz-Dahlmann, B., Beyer, C. & Seitz, J., 2018, In : The World Journal of Biological Psychiatry. 19, 3, p. 225-235 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Frintrop, L., Liesbrock, J., Paulukat, L., Johann, S., Kas, M. J., Tolba, R., ... Seitz, J. (2018). Reduced astrocyte density underlying brain volume reduction inactivity-based anorexia rats. The World Journal of Biological Psychiatry, 19(3), 225-235. https://doi.org/10.1080/15622975.2016.1273552

Author

Frintrop, Linda ; Liesbrock, Johanna ; Paulukat, Lisa ; Johann, Sonja ; Kas, Martien J. ; Tolba, Rene ; Heussen, Nicole ; Neulen, Joseph ; Konrad, Kerstin ; Herpertz-Dahlmann, Beate ; Beyer, Cordian ; Seitz, Jochen. / Reduced astrocyte density underlying brain volume reduction inactivity-based anorexia rats. In: The World Journal of Biological Psychiatry. 2018 ; Vol. 19, No. 3. pp. 225-235.

Harvard

Frintrop, L, Liesbrock, J, Paulukat, L, Johann, S, Kas, MJ, Tolba, R, Heussen, N, Neulen, J, Konrad, K, Herpertz-Dahlmann, B, Beyer, C & Seitz, J 2018, 'Reduced astrocyte density underlying brain volume reduction inactivity-based anorexia rats', The World Journal of Biological Psychiatry, vol. 19, no. 3, pp. 225-235. https://doi.org/10.1080/15622975.2016.1273552

Standard

Reduced astrocyte density underlying brain volume reduction inactivity-based anorexia rats. / Frintrop, Linda; Liesbrock, Johanna; Paulukat, Lisa; Johann, Sonja; Kas, Martien J.; Tolba, Rene; Heussen, Nicole; Neulen, Joseph; Konrad, Kerstin; Herpertz-Dahlmann, Beate; Beyer, Cordian; Seitz, Jochen.

In: The World Journal of Biological Psychiatry, Vol. 19, No. 3, 2018, p. 225-235.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Frintrop L, Liesbrock J, Paulukat L, Johann S, Kas MJ, Tolba R et al. Reduced astrocyte density underlying brain volume reduction inactivity-based anorexia rats. The World Journal of Biological Psychiatry. 2018;19(3):225-235. https://doi.org/10.1080/15622975.2016.1273552


BibTeX

@article{9cb2d8270955476d829f867940de46b8,
title = "Reduced astrocyte density underlying brain volume reduction inactivity-based anorexia rats",
abstract = "OBJECTIVES: Severe grey and white matter volume reductions were found in patients with anorexia nervosa (AN) that were linked to neuropsychological deficits while their underlying pathophysiology remains unclear. For the first time, we analysed the cellular basis of brain volume changes in an animal model (activity-based anorexia, ABA).METHODS: Female rats had 24 h/day running wheel access and received reduced food intake until a 25{\%} weight reduction was reached and maintained for 2 weeks.RESULTS: In ABA rats, the volumes of the cerebral cortex and corpus callosum were significantly reduced compared to controls by 6{\%} and 9{\%}, respectively. The number of GFAP-positive astrocytes in these regions decreased by 39{\%} and 23{\%}, total astrocyte-covered area by 83{\%} and 63{\%}. In neurons no changes were observed. The findings were complemented by a 60{\%} and 49{\%} reduction in astrocyte (GFAP) mRNA expression.CONCLUSIONS: Volumetric brain changes in ABA animals mirror those in human AN patients. These alterations are associated with a reduction of GFAP-positive astrocytes as well as GFAP expression. Reduced astrocyte functioning could help explain neuronal dysfunctions leading to symptoms of rigidity and impaired learning. Astrocyte loss could constitute a new research target for understanding and treating semi-starvation and AN.",
keywords = "ABA rat model, anorexia nervosa, astrocytes, corpus callosum, cortex volume, EATING-DISORDERS, MORPHOLOGICAL-CHANGES, SELF-STARVATION, ESTROUS-CYCLE, NERVOSA, ADOLESCENT, ABNORMALITIES, HYPERACTIVITY, STEROIDS, FEMALES",
author = "Linda Frintrop and Johanna Liesbrock and Lisa Paulukat and Sonja Johann and Kas, {Martien J.} and Rene Tolba and Nicole Heussen and Joseph Neulen and Kerstin Konrad and Beate Herpertz-Dahlmann and Cordian Beyer and Jochen Seitz",
year = "2018",
doi = "10.1080/15622975.2016.1273552",
language = "English",
volume = "19",
pages = "225--235",
journal = "The World Journal of Biological Psychiatry",
issn = "1562-2975",
publisher = "Taylor & Francis Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Reduced astrocyte density underlying brain volume reduction inactivity-based anorexia rats

AU - Frintrop, Linda

AU - Liesbrock, Johanna

AU - Paulukat, Lisa

AU - Johann, Sonja

AU - Kas, Martien J.

AU - Tolba, Rene

AU - Heussen, Nicole

AU - Neulen, Joseph

AU - Konrad, Kerstin

AU - Herpertz-Dahlmann, Beate

AU - Beyer, Cordian

AU - Seitz, Jochen

PY - 2018

Y1 - 2018

N2 - OBJECTIVES: Severe grey and white matter volume reductions were found in patients with anorexia nervosa (AN) that were linked to neuropsychological deficits while their underlying pathophysiology remains unclear. For the first time, we analysed the cellular basis of brain volume changes in an animal model (activity-based anorexia, ABA).METHODS: Female rats had 24 h/day running wheel access and received reduced food intake until a 25% weight reduction was reached and maintained for 2 weeks.RESULTS: In ABA rats, the volumes of the cerebral cortex and corpus callosum were significantly reduced compared to controls by 6% and 9%, respectively. The number of GFAP-positive astrocytes in these regions decreased by 39% and 23%, total astrocyte-covered area by 83% and 63%. In neurons no changes were observed. The findings were complemented by a 60% and 49% reduction in astrocyte (GFAP) mRNA expression.CONCLUSIONS: Volumetric brain changes in ABA animals mirror those in human AN patients. These alterations are associated with a reduction of GFAP-positive astrocytes as well as GFAP expression. Reduced astrocyte functioning could help explain neuronal dysfunctions leading to symptoms of rigidity and impaired learning. Astrocyte loss could constitute a new research target for understanding and treating semi-starvation and AN.

AB - OBJECTIVES: Severe grey and white matter volume reductions were found in patients with anorexia nervosa (AN) that were linked to neuropsychological deficits while their underlying pathophysiology remains unclear. For the first time, we analysed the cellular basis of brain volume changes in an animal model (activity-based anorexia, ABA).METHODS: Female rats had 24 h/day running wheel access and received reduced food intake until a 25% weight reduction was reached and maintained for 2 weeks.RESULTS: In ABA rats, the volumes of the cerebral cortex and corpus callosum were significantly reduced compared to controls by 6% and 9%, respectively. The number of GFAP-positive astrocytes in these regions decreased by 39% and 23%, total astrocyte-covered area by 83% and 63%. In neurons no changes were observed. The findings were complemented by a 60% and 49% reduction in astrocyte (GFAP) mRNA expression.CONCLUSIONS: Volumetric brain changes in ABA animals mirror those in human AN patients. These alterations are associated with a reduction of GFAP-positive astrocytes as well as GFAP expression. Reduced astrocyte functioning could help explain neuronal dysfunctions leading to symptoms of rigidity and impaired learning. Astrocyte loss could constitute a new research target for understanding and treating semi-starvation and AN.

KW - ABA rat model

KW - anorexia nervosa

KW - astrocytes

KW - corpus callosum

KW - cortex volume

KW - EATING-DISORDERS

KW - MORPHOLOGICAL-CHANGES

KW - SELF-STARVATION

KW - ESTROUS-CYCLE

KW - NERVOSA

KW - ADOLESCENT

KW - ABNORMALITIES

KW - HYPERACTIVITY

KW - STEROIDS

KW - FEMALES

U2 - 10.1080/15622975.2016.1273552

DO - 10.1080/15622975.2016.1273552

M3 - Article

VL - 19

SP - 225

EP - 235

JO - The World Journal of Biological Psychiatry

JF - The World Journal of Biological Psychiatry

SN - 1562-2975

IS - 3

ER -

ID: 39530283