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Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe

Veronesi, G., Baldwin, D. R., Henschke, C. I., Ghislandi, S., Iavicoli, S., Oudkerk, M., De Koning, H. J., Shemesh, J., Field, J. K., Zulueta, J. J., Horgan, D., Fiestas Navarrete, L., Valentino Infante, M., Novellis, P., Murray, R. L., Peled, N., Rampinelli, C., Rocco, G., Rzyman, W., Scagliotti, G. V., Tammemagi, M. C., Bertolaccini, L., Triphuridet, N., Yip, R., Rossi, A., Senan, S., Ferrante, G., Brain, K., van der Aalst, C., Bonomo, L., Consonni, D., Van Meerbeeck, J. P., Maisonneuve, P., Novello, S., Devaraj, A., Saghir, Z. & Pelosi, G., 24-Jun-2020, In : Cancers. 12, 6, p. 1-24 24 p., 1672.

Research output: Contribution to journalReview articleAcademicpeer-review

  • Giulia Veronesi
  • David R. Baldwin
  • Claudia I. Henschke
  • Simone Ghislandi
  • Sergio Iavicoli
  • Matthijs Oudkerk
  • Harry J. De Koning
  • Joseph Shemesh
  • John K. Field
  • Javier J. Zulueta
  • Denis Horgan
  • Lucia Fiestas Navarrete
  • Maurizio Valentino Infante
  • Pierluigi Novellis
  • Rachael L. Murray
  • Nir Peled
  • Cristiano Rampinelli
  • Gaetano Rocco
  • Witold Rzyman
  • Giorgio Vittorio Scagliotti
  • Martin C. Tammemagi
  • Luca Bertolaccini
  • Natthaya Triphuridet
  • Rowena Yip
  • Alexia Rossi
  • Suresh Senan
  • Giuseppe Ferrante
  • Kate Brain
  • Carlijn van der Aalst
  • Lorenzo Bonomo
  • Dario Consonni
  • Jan P. Van Meerbeeck
  • Patrick Maisonneuve
  • Silvia Novello
  • Anand Devaraj
  • Zaigham Saghir
  • Giuseppe Pelosi

Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39-61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the "Initiative for European Lung Screening (IELS)"-a large international group of physicians and other experts concerned with lung cancer-agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached.

Original languageEnglish
Article number1672
Pages (from-to)1-24
Number of pages24
JournalCancers
Volume12
Issue number6
Publication statusPublished - 24-Jun-2020

    Keywords

  • consensus, statement, screening, lung cancer, mortality, reduction, low dose, computed tomography, implementation, OBSTRUCTIVE PULMONARY-DISEASE, SMOKING-CESSATION INTERVENTION, RISK PREDICTION MODEL, BASE-LINE, COST-EFFECTIVENESS, MALIGNANT MESOTHELIOMA, SELECTION CRITERIA, ASBESTOS EXPOSURE, INDIVIDUAL RISK, GLOBAL BURDEN

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