Recombinant human C1-inhibitor in the treatment of acute angioedema attacksChoi, G., Soeters, M. R., Farkas, H., Varga, L., Obtulowicz, K., Bilo, B., Porebski, G., Hack, C. E., Verdonk, R., Nuijens, J. & Levi, M., Jun-2007, In : Transfusion. 47, 6, p. 1028-1032 5 p.
Research output: Contribution to journal › Article › Academic › peer-review
Background: Patients with hereditary C1-inhibitor deficiency have recurrent attacks of angioedema, preferably treated with C1-inhibitor concentrate. A recombinant human C1-inhibitor (rHuC1INH) was developed, derived from milk from transgenic rabbits. This study was undertaken to investigate the effects of rHuC1INH in the treatment of acute angioedema attacks in patients with a hereditary C1-inhibitor deficiency.
Study Design and Methods: Patients with hereditary C1-inhibitor deficiency were treated with rHuC1INH (at a dose of 100 U/kg) within 8 hours after onset of an acute attack. Time to initiation of relief and time to minimal symptoms were reported by both the patient and the treating physician.
Results: Thirteen severe angioedema attacks in 9 patients with hereditary C1-inhibitor deficiency were treated with rHuC1INH. There was rapid improvement of clinical conditions for all attacks, with approximately 80 percent of treated patients experiencing symptom relief within 2 hours and minimal symptoms within 12 hours. There were no drug-related adverse events or immunogenic reactions to C1-inhibitor or rabbit proteins.
Conclusion: The transgenically produced rHuC1INH was successfully used in the treatment of acute angioedema attacks in patients with hereditary C1-inhibitor deficiency.
|Number of pages||5|
|Publication status||Published - Jun-2007|
- C1 INHIBITOR CONCENTRATE, HEREDITARY ANGIOEDEMA, DEFICIENCY, THERAPY