Recent Applications of Carbon‐Nitrogen Lyases in Asymmetric Synthesis of Noncanonical Amino Acids and Heterocyclic Compounds

Zhang, J., Abidin, M. Z., Saravanan, T. & Poelarends, G. J., 21-Apr-2020, In : ChemBioChem. 21, 19, p. 2733-2742 10 p.

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Carbon-nitrogen (C−N) lyases are enzymes that normally catalyze the cleavage of C−N bonds. Reversing this reaction towards carbon-nitrogen bond formation can be a powerful approach to prepare valuable compounds that could find applications in everyday life. This review focuses on recent (last five years) applications of native and engineered C−N lyases, either as stand-alone biocatalysts or as part of multienzymatic and chemoenzymatic cascades, in enantioselective synthesis of noncanonical amino acids and dinitrogen-fused heterocycles, which are useful tools for neurobiological research and important synthetic precursors to pharmaceuticals and food additives.

Original languageEnglish
Pages (from-to)2733-2742
Number of pages10
Issue number19
Publication statusE-pub ahead of print - 21-Apr-2020

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