Publication

Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine

Brandsma, C-A., Van den Berge, M., Hackett, T-L., Brusselle, G. & Timens, W., 3-Dec-2019, In : JOURNAL OF PATHOLOGY. 250, 5, p. 624-635 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Brandsma, C-A., Van den Berge, M., Hackett, T-L., Brusselle, G., & Timens, W. (2019). Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine. JOURNAL OF PATHOLOGY, 250(5), 624-635. https://doi.org/10.1002/path.5364

Author

Brandsma, Corry-Anke ; Van den Berge, Maarten ; Hackett, Tillie-Louise ; Brusselle, Guy ; Timens, Wim. / Recent advances in chronic obstructive pulmonary disease pathogenesis : from disease mechanisms to precision medicine. In: JOURNAL OF PATHOLOGY. 2019 ; Vol. 250, No. 5. pp. 624-635.

Harvard

Brandsma, C-A, Van den Berge, M, Hackett, T-L, Brusselle, G & Timens, W 2019, 'Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine', JOURNAL OF PATHOLOGY, vol. 250, no. 5, pp. 624-635. https://doi.org/10.1002/path.5364

Standard

Recent advances in chronic obstructive pulmonary disease pathogenesis : from disease mechanisms to precision medicine. / Brandsma, Corry-Anke; Van den Berge, Maarten; Hackett, Tillie-Louise; Brusselle, Guy; Timens, Wim.

In: JOURNAL OF PATHOLOGY, Vol. 250, No. 5, 03.12.2019, p. 624-635.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Brandsma C-A, Van den Berge M, Hackett T-L, Brusselle G, Timens W. Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine. JOURNAL OF PATHOLOGY. 2019 Dec 3;250(5):624-635. https://doi.org/10.1002/path.5364


BibTeX

@article{d1ccb3b8b833433f9fb218fd42c56490,
title = "Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine",
abstract = "Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high personal and societal burden. Exposure to toxic particles and gases, including cigarette smoke, is the main risk factor for COPD. Together with smoking cessation, current treatment strategies of COPD aim to improve symptoms and prevent exacerbations, but there is no disease-modifying treatment. The biggest drawback of today's COPD treatment regimen is the 'one size fits all' pharmacological intervention, mainly based on disease severity and symptoms and not the individual's disease pathology. To halt the worrying increase in the burden of COPD, disease management needs to be advanced with a focus on personalized treatment. The main pathological feature of COPD includes a chronic and abnormal inflammatory response within the lungs, which results in airway and alveolar changes in the lung as reflected by (small) airways disease and emphysema. Here we discuss recent developments related to the abnormal inflammatory response, ECM and age-related changes, structural changes in the small airways and the role of sex-related differences, which are all relevant to explain the individual differences in the disease pathology of COPD and improve disease endotyping. Furthermore, we will discuss the most recent developments of new treatment strategies using biologicals to target specific pathological features or disease endotypes of COPD. (c) 2019 Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.",
keywords = "COPD, inflammation, aging, ECM, genome-wide association study, CELSR1, sex differences, small airways, precision imaging, personalized treatment, biologics, SMALL-AIRWAY OBSTRUCTION, INNATE LYMPHOID-CELLS, EXTRACELLULAR-MATRIX, LUNG-FUNCTION, COMPUTED-TOMOGRAPHY, SEX-DIFFERENCES, GENDER-DIFFERENCES, SMOKING-CESSATION, ELASTIC FIBERS, SEVERE COPD",
author = "Corry-Anke Brandsma and {Van den Berge}, Maarten and Tillie-Louise Hackett and Guy Brusselle and Wim Timens",
note = "This article is protected by copyright. All rights reserved.",
year = "2019",
month = dec,
day = "3",
doi = "10.1002/path.5364",
language = "English",
volume = "250",
pages = "624--635",
journal = "JOURNAL OF PATHOLOGY",
issn = "0022-3417",
publisher = "Wiley",
number = "5",

}

RIS

TY - JOUR

T1 - Recent advances in chronic obstructive pulmonary disease pathogenesis

T2 - from disease mechanisms to precision medicine

AU - Brandsma, Corry-Anke

AU - Van den Berge, Maarten

AU - Hackett, Tillie-Louise

AU - Brusselle, Guy

AU - Timens, Wim

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/12/3

Y1 - 2019/12/3

N2 - Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high personal and societal burden. Exposure to toxic particles and gases, including cigarette smoke, is the main risk factor for COPD. Together with smoking cessation, current treatment strategies of COPD aim to improve symptoms and prevent exacerbations, but there is no disease-modifying treatment. The biggest drawback of today's COPD treatment regimen is the 'one size fits all' pharmacological intervention, mainly based on disease severity and symptoms and not the individual's disease pathology. To halt the worrying increase in the burden of COPD, disease management needs to be advanced with a focus on personalized treatment. The main pathological feature of COPD includes a chronic and abnormal inflammatory response within the lungs, which results in airway and alveolar changes in the lung as reflected by (small) airways disease and emphysema. Here we discuss recent developments related to the abnormal inflammatory response, ECM and age-related changes, structural changes in the small airways and the role of sex-related differences, which are all relevant to explain the individual differences in the disease pathology of COPD and improve disease endotyping. Furthermore, we will discuss the most recent developments of new treatment strategies using biologicals to target specific pathological features or disease endotypes of COPD. (c) 2019 Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

AB - Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high personal and societal burden. Exposure to toxic particles and gases, including cigarette smoke, is the main risk factor for COPD. Together with smoking cessation, current treatment strategies of COPD aim to improve symptoms and prevent exacerbations, but there is no disease-modifying treatment. The biggest drawback of today's COPD treatment regimen is the 'one size fits all' pharmacological intervention, mainly based on disease severity and symptoms and not the individual's disease pathology. To halt the worrying increase in the burden of COPD, disease management needs to be advanced with a focus on personalized treatment. The main pathological feature of COPD includes a chronic and abnormal inflammatory response within the lungs, which results in airway and alveolar changes in the lung as reflected by (small) airways disease and emphysema. Here we discuss recent developments related to the abnormal inflammatory response, ECM and age-related changes, structural changes in the small airways and the role of sex-related differences, which are all relevant to explain the individual differences in the disease pathology of COPD and improve disease endotyping. Furthermore, we will discuss the most recent developments of new treatment strategies using biologicals to target specific pathological features or disease endotypes of COPD. (c) 2019 Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

KW - COPD

KW - inflammation

KW - aging

KW - ECM

KW - genome-wide association study

KW - CELSR1

KW - sex differences

KW - small airways

KW - precision imaging

KW - personalized treatment

KW - biologics

KW - SMALL-AIRWAY OBSTRUCTION

KW - INNATE LYMPHOID-CELLS

KW - EXTRACELLULAR-MATRIX

KW - LUNG-FUNCTION

KW - COMPUTED-TOMOGRAPHY

KW - SEX-DIFFERENCES

KW - GENDER-DIFFERENCES

KW - SMOKING-CESSATION

KW - ELASTIC FIBERS

KW - SEVERE COPD

U2 - 10.1002/path.5364

DO - 10.1002/path.5364

M3 - Review article

C2 - 31691283

VL - 250

SP - 624

EP - 635

JO - JOURNAL OF PATHOLOGY

JF - JOURNAL OF PATHOLOGY

SN - 0022-3417

IS - 5

ER -

ID: 102130842