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Real-world treatment patterns and outcomes of patients with extensive disease small cell lung cancer

Santeon SCLC Study Grp, Cramer-van der Welle, C. M., Schramel, F. M. N. H., van Leeuwen, A. S., Groen, H. J. M. & van de Garde, E. M. W., 14-May-2020, In : European journal of cancer care. p. e13250 6 p., 13250.

Research output: Contribution to journalArticleAcademicpeer-review

  • Santeon SCLC Study Grp
  • Christine M. Cramer-van der Welle
  • Franz M. N. H. Schramel
  • Arvid S. van Leeuwen
  • Harry J. M. Groen
  • Ewoudt M. W. van de Garde

Objective Clinical outcome data on patients with extensive disease small cell lung cancer (ED SCLC) treated in routine practice is limited. The aim of this retrospective study is to present data on treatment patterns and survival in an unselected patient population with ED SCLC.

Methods All patients diagnosed with ED SCLC between 2008 and 2014 in six Dutch large teaching hospitals (Santeon network) were included. We collected data on patient characteristics, systemic treatments, overall survival (OS), dose reductions (

Results From 792 diagnosed patients, 568 (72%) started with first-line treatment. Of these patients, 41% received second-line treatment. Only 68 patients received third-line treatment. For all treated patients, the mean age was 66 years. The majority (72%) had a performance status (ECOG) of 0 or 1 at diagnosis. Median OS of treated patients was 7.4 months. Of all patients with first-line treatment, 26% received

Conclusion After first-line systemic treatment in ED SCLC the fraction of patients receiving subsequent lines of treatment is rapidly decreasing. This information is necessary as background for evaluation of the added value of future drugs under study for ED SCLC.

Original languageEnglish
Article number13250
Pages (from-to)e13250
Number of pages6
JournalEuropean journal of cancer care
Early online date2020
Publication statusPublished - 14-May-2020

    Keywords

  • effectiveness, pharmacotherapy, real-world, small cell lung cancer, survival, treatment patterns, NETHERLANDS, SURVIVAL, PROGRESS

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