Publication

Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs

Lexmond, A. J., Singh, D., Frijlink, H. W., Clarke, G. W., Page, C. P., Forbes, B. & van den Berge, M., Apr-2018, In : Pulmonary Pharmacology & Therapeutics. 49, p. 27-35 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Lexmond, A. J., Singh, D., Frijlink, H. W., Clarke, G. W., Page, C. P., Forbes, B., & van den Berge, M. (2018). Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs. Pulmonary Pharmacology & Therapeutics, 49, 27-35. https://doi.org/10.1016/j.pupt.2018.01.004

Author

Lexmond, Anne J. ; Singh, Dave ; Frijlink, Henderik W. ; Clarke, Graham W. ; Page, Clive P. ; Forbes, Ben ; van den Berge, Maarten. / Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs. In: Pulmonary Pharmacology & Therapeutics. 2018 ; Vol. 49. pp. 27-35.

Harvard

Lexmond, AJ, Singh, D, Frijlink, HW, Clarke, GW, Page, CP, Forbes, B & van den Berge, M 2018, 'Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs', Pulmonary Pharmacology & Therapeutics, vol. 49, pp. 27-35. https://doi.org/10.1016/j.pupt.2018.01.004

Standard

Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs. / Lexmond, Anne J.; Singh, Dave; Frijlink, Henderik W.; Clarke, Graham W.; Page, Clive P.; Forbes, Ben; van den Berge, Maarten.

In: Pulmonary Pharmacology & Therapeutics, Vol. 49, 04.2018, p. 27-35.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Lexmond AJ, Singh D, Frijlink HW, Clarke GW, Page CP, Forbes B et al. Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs. Pulmonary Pharmacology & Therapeutics. 2018 Apr;49:27-35. https://doi.org/10.1016/j.pupt.2018.01.004


BibTeX

@article{72624b3e46e94507aae46820ba42da60,
title = "Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs",
abstract = "Inhaled airway challenges provoke bronchoconstriction in susceptible subjects and are a pivotal tool in the diagnosis and monitoring of obstructive lung diseases, both in the clinic and in the development of new respiratory medicines. This article reviews the main challenge agents that are in use today (methacholine, mannitol, adenosine, allergens, endotoxin) and emphasises the importance of controlling how these agents are administered. There is a danger that the optimal value of these challenge agents may not be realised due to suboptimal inhaled delivery; thus considerations for effective and reproducible challenge delivery are provided. This article seeks to increase awareness of the importance of precise delivery of inhaled agents used to challenge the airways for diagnosis and research, and is intended as a stepping stone towards much-needed standardisation and harmonisation in the administration of inhaled airway challenge agents.",
keywords = "Asthma, Bronchial challenge test, Bronchial hyperresponsiveness, Delivery method optimisation, Delivery method standardisation, Drug delivery, adenosine, allergen, endotoxin, lipopolysaccharide, mannitol, methacholine, aerosol, bronchial challenge testing, bronchoconstriction, disease severity, drug delivery system, drug distribution, human, inhalation test, inhaled airway challenge, morphology, nebulization, oropharynx, priority journal, respiratory tract disease assessment, review, standardization, tracheobronchial tree",
author = "Lexmond, {Anne J.} and Dave Singh and Frijlink, {Henderik W.} and Clarke, {Graham W.} and Page, {Clive P.} and Ben Forbes and {van den Berge}, Maarten",
note = "Copyright {\circledC} 2018. Published by Elsevier Ltd.",
year = "2018",
month = "4",
doi = "10.1016/j.pupt.2018.01.004",
language = "English",
volume = "49",
pages = "27--35",
journal = "Pulmonary Pharmacology & Therapeutics",
issn = "1094-5539",
publisher = "ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - Realising the potential of various inhaled airway challenge agents through improved delivery to the lungs

AU - Lexmond, Anne J.

AU - Singh, Dave

AU - Frijlink, Henderik W.

AU - Clarke, Graham W.

AU - Page, Clive P.

AU - Forbes, Ben

AU - van den Berge, Maarten

N1 - Copyright © 2018. Published by Elsevier Ltd.

PY - 2018/4

Y1 - 2018/4

N2 - Inhaled airway challenges provoke bronchoconstriction in susceptible subjects and are a pivotal tool in the diagnosis and monitoring of obstructive lung diseases, both in the clinic and in the development of new respiratory medicines. This article reviews the main challenge agents that are in use today (methacholine, mannitol, adenosine, allergens, endotoxin) and emphasises the importance of controlling how these agents are administered. There is a danger that the optimal value of these challenge agents may not be realised due to suboptimal inhaled delivery; thus considerations for effective and reproducible challenge delivery are provided. This article seeks to increase awareness of the importance of precise delivery of inhaled agents used to challenge the airways for diagnosis and research, and is intended as a stepping stone towards much-needed standardisation and harmonisation in the administration of inhaled airway challenge agents.

AB - Inhaled airway challenges provoke bronchoconstriction in susceptible subjects and are a pivotal tool in the diagnosis and monitoring of obstructive lung diseases, both in the clinic and in the development of new respiratory medicines. This article reviews the main challenge agents that are in use today (methacholine, mannitol, adenosine, allergens, endotoxin) and emphasises the importance of controlling how these agents are administered. There is a danger that the optimal value of these challenge agents may not be realised due to suboptimal inhaled delivery; thus considerations for effective and reproducible challenge delivery are provided. This article seeks to increase awareness of the importance of precise delivery of inhaled agents used to challenge the airways for diagnosis and research, and is intended as a stepping stone towards much-needed standardisation and harmonisation in the administration of inhaled airway challenge agents.

KW - Asthma

KW - Bronchial challenge test

KW - Bronchial hyperresponsiveness

KW - Delivery method optimisation

KW - Delivery method standardisation

KW - Drug delivery

KW - adenosine

KW - allergen

KW - endotoxin

KW - lipopolysaccharide

KW - mannitol

KW - methacholine

KW - aerosol

KW - bronchial challenge testing

KW - bronchoconstriction

KW - disease severity

KW - drug delivery system

KW - drug distribution

KW - human

KW - inhalation test

KW - inhaled airway challenge

KW - morphology

KW - nebulization

KW - oropharynx

KW - priority journal

KW - respiratory tract disease assessment

KW - review

KW - standardization

KW - tracheobronchial tree

U2 - 10.1016/j.pupt.2018.01.004

DO - 10.1016/j.pupt.2018.01.004

M3 - Review article

C2 - 29331645

VL - 49

SP - 27

EP - 35

JO - Pulmonary Pharmacology & Therapeutics

JF - Pulmonary Pharmacology & Therapeutics

SN - 1094-5539

ER -

ID: 55332762