Publication

Rate, spectrum, and evolutionary dynamics of spontaneous epimutations

van der Graaf, A., Wardenaar, R., Neumann, D. A., Taudt, A., Shaw, R. G., Jansen, R. C., Schmitz, R. J., Colome-Tatche, M. & Johannes, F., 26-May-2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 21, p. 6676-6681 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

van der Graaf, A., Wardenaar, R., Neumann, D. A., Taudt, A., Shaw, R. G., Jansen, R. C., ... Johannes, F. (2015). Rate, spectrum, and evolutionary dynamics of spontaneous epimutations. Proceedings of the National Academy of Sciences of the United States of America, 112(21), 6676-6681. https://doi.org/10.1073/pnas.1424254112

Author

van der Graaf, Adriaan ; Wardenaar, Renee ; Neumann, Drexel A. ; Taudt, Aaron ; Shaw, Ruth G. ; Jansen, Ritsert C. ; Schmitz, Robert J. ; Colome-Tatche, Maria ; Johannes, Frank. / Rate, spectrum, and evolutionary dynamics of spontaneous epimutations. In: Proceedings of the National Academy of Sciences of the United States of America. 2015 ; Vol. 112, No. 21. pp. 6676-6681.

Harvard

van der Graaf, A, Wardenaar, R, Neumann, DA, Taudt, A, Shaw, RG, Jansen, RC, Schmitz, RJ, Colome-Tatche, M & Johannes, F 2015, 'Rate, spectrum, and evolutionary dynamics of spontaneous epimutations', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 21, pp. 6676-6681. https://doi.org/10.1073/pnas.1424254112

Standard

Rate, spectrum, and evolutionary dynamics of spontaneous epimutations. / van der Graaf, Adriaan; Wardenaar, Renee; Neumann, Drexel A.; Taudt, Aaron; Shaw, Ruth G.; Jansen, Ritsert C.; Schmitz, Robert J.; Colome-Tatche, Maria; Johannes, Frank.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, No. 21, 26.05.2015, p. 6676-6681.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

van der Graaf A, Wardenaar R, Neumann DA, Taudt A, Shaw RG, Jansen RC et al. Rate, spectrum, and evolutionary dynamics of spontaneous epimutations. Proceedings of the National Academy of Sciences of the United States of America. 2015 May 26;112(21):6676-6681. https://doi.org/10.1073/pnas.1424254112


BibTeX

@article{e4534ad022ec438ebb4c0c4d88ca1918,
title = "Rate, spectrum, and evolutionary dynamics of spontaneous epimutations",
abstract = "Stochastic changes in cytosine methylation are a source of heritable epigenetic and phenotypic diversity in plants. Using the model plant Arabidopsis thaliana, we derive robust estimates of the rate at which methylation is spontaneously gained (forward epimutation) or lost (backward epimutation) at individual cytosines and construct a comprehensive picture of the epimutation landscape in this species. We demonstrate that the dynamic interplay between forward and backward epimutations is modulated by genomic context and show that subtle contextual differences have profoundly shaped patterns of methylation diversity in A. thaliana natural populations over evolutionary timescales. Theoretical arguments indicate that the epimutation rates reported here are high enough to rapidly uncouple genetic from epigenetic variation, but low enough for new epialleles to sustain long-term selection responses. Our results provide new insights into methylome evolution and its population-level consequences.",
keywords = "epigenetics, epimutation, DNA methylation, evolution, Arabidopsis, ARABIDOPSIS-THALIANA, DNA METHYLATION, EPIGENETIC VARIATION, PLANT EVOLUTION, INHERITANCE, HETEROCHROMATIN, EPIALLELES, MUTATIONS, EPIGENOME, SELECTION",
author = "{van der Graaf}, Adriaan and Renee Wardenaar and Neumann, {Drexel A.} and Aaron Taudt and Shaw, {Ruth G.} and Jansen, {Ritsert C.} and Schmitz, {Robert J.} and Maria Colome-Tatche and Frank Johannes",
year = "2015",
month = "5",
day = "26",
doi = "10.1073/pnas.1424254112",
language = "English",
volume = "112",
pages = "6676--6681",
journal = "Proceedings of the National Academy of Science of the United States of America",
issn = "0027-8424",
publisher = "NATL ACAD SCIENCES",
number = "21",

}

RIS

TY - JOUR

T1 - Rate, spectrum, and evolutionary dynamics of spontaneous epimutations

AU - van der Graaf, Adriaan

AU - Wardenaar, Renee

AU - Neumann, Drexel A.

AU - Taudt, Aaron

AU - Shaw, Ruth G.

AU - Jansen, Ritsert C.

AU - Schmitz, Robert J.

AU - Colome-Tatche, Maria

AU - Johannes, Frank

PY - 2015/5/26

Y1 - 2015/5/26

N2 - Stochastic changes in cytosine methylation are a source of heritable epigenetic and phenotypic diversity in plants. Using the model plant Arabidopsis thaliana, we derive robust estimates of the rate at which methylation is spontaneously gained (forward epimutation) or lost (backward epimutation) at individual cytosines and construct a comprehensive picture of the epimutation landscape in this species. We demonstrate that the dynamic interplay between forward and backward epimutations is modulated by genomic context and show that subtle contextual differences have profoundly shaped patterns of methylation diversity in A. thaliana natural populations over evolutionary timescales. Theoretical arguments indicate that the epimutation rates reported here are high enough to rapidly uncouple genetic from epigenetic variation, but low enough for new epialleles to sustain long-term selection responses. Our results provide new insights into methylome evolution and its population-level consequences.

AB - Stochastic changes in cytosine methylation are a source of heritable epigenetic and phenotypic diversity in plants. Using the model plant Arabidopsis thaliana, we derive robust estimates of the rate at which methylation is spontaneously gained (forward epimutation) or lost (backward epimutation) at individual cytosines and construct a comprehensive picture of the epimutation landscape in this species. We demonstrate that the dynamic interplay between forward and backward epimutations is modulated by genomic context and show that subtle contextual differences have profoundly shaped patterns of methylation diversity in A. thaliana natural populations over evolutionary timescales. Theoretical arguments indicate that the epimutation rates reported here are high enough to rapidly uncouple genetic from epigenetic variation, but low enough for new epialleles to sustain long-term selection responses. Our results provide new insights into methylome evolution and its population-level consequences.

KW - epigenetics

KW - epimutation

KW - DNA methylation

KW - evolution

KW - Arabidopsis

KW - ARABIDOPSIS-THALIANA

KW - DNA METHYLATION

KW - EPIGENETIC VARIATION

KW - PLANT EVOLUTION

KW - INHERITANCE

KW - HETEROCHROMATIN

KW - EPIALLELES

KW - MUTATIONS

KW - EPIGENOME

KW - SELECTION

U2 - 10.1073/pnas.1424254112

DO - 10.1073/pnas.1424254112

M3 - Article

C2 - 25964364

VL - 112

SP - 6676

EP - 6681

JO - Proceedings of the National Academy of Science of the United States of America

JF - Proceedings of the National Academy of Science of the United States of America

SN - 0027-8424

IS - 21

ER -

ID: 19671505