Publication

Rate of improvement during and across three treatments for panic disorder with or without agoraphobia: Cognitive behavioral therapy, selective serotonin reuptake inhibitor or both combined

Van Apeldoorn, F. J., Van Hout, W. J. P. J., Timmerman, M. E., Mersch, P. P. A. & den Boer, J. A., 5-Sep-2013, In : Journal of Affective Disorders. 150, 2, p. 313-319 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Van Apeldoorn, F. J., Van Hout, W. J. P. J., Timmerman, M. E., Mersch, P. P. A., & den Boer, J. A. (2013). Rate of improvement during and across three treatments for panic disorder with or without agoraphobia: Cognitive behavioral therapy, selective serotonin reuptake inhibitor or both combined. Journal of Affective Disorders, 150(2), 313-319. https://doi.org/10.1016/j.jad.2013.04.012

Author

Van Apeldoorn, Franske J. ; Van Hout, Wiljo J. P. J. ; Timmerman, Marieke E. ; Mersch, Peter Paul A. ; den Boer, Johan A. / Rate of improvement during and across three treatments for panic disorder with or without agoraphobia : Cognitive behavioral therapy, selective serotonin reuptake inhibitor or both combined. In: Journal of Affective Disorders. 2013 ; Vol. 150, No. 2. pp. 313-319.

Harvard

Van Apeldoorn, FJ, Van Hout, WJPJ, Timmerman, ME, Mersch, PPA & den Boer, JA 2013, 'Rate of improvement during and across three treatments for panic disorder with or without agoraphobia: Cognitive behavioral therapy, selective serotonin reuptake inhibitor or both combined', Journal of Affective Disorders, vol. 150, no. 2, pp. 313-319. https://doi.org/10.1016/j.jad.2013.04.012

Standard

Rate of improvement during and across three treatments for panic disorder with or without agoraphobia : Cognitive behavioral therapy, selective serotonin reuptake inhibitor or both combined. / Van Apeldoorn, Franske J.; Van Hout, Wiljo J. P. J.; Timmerman, Marieke E.; Mersch, Peter Paul A.; den Boer, Johan A.

In: Journal of Affective Disorders, Vol. 150, No. 2, 05.09.2013, p. 313-319.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Van Apeldoorn FJ, Van Hout WJPJ, Timmerman ME, Mersch PPA, den Boer JA. Rate of improvement during and across three treatments for panic disorder with or without agoraphobia: Cognitive behavioral therapy, selective serotonin reuptake inhibitor or both combined. Journal of Affective Disorders. 2013 Sep 5;150(2):313-319. https://doi.org/10.1016/j.jad.2013.04.012


BibTeX

@article{5f9cd274f4024de380ba5abd5e2e1a78,
title = "Rate of improvement during and across three treatments for panic disorder with or without agoraphobia: Cognitive behavioral therapy, selective serotonin reuptake inhibitor or both combined",
abstract = "Background: Existing literature on panic disorder (PD) yields no data regarding the differential rates of improvement during Cognitive Behavioral Therapy (CBT), Selective Serotonin Reuptake Inhibitor (SSRI) or both combined (CBT+SSRI).Method: Patients were randomized to CBT, SSRI or CBT+SSRI which each lasted one year including three months of medication taper. Participating patients kept record of the frequency of panic attacks throughout the full year of treatment. Rate of improvement on panic frequency and the relationship between rate of improvement and baseline agoraphobia (AG) were examined.Results: A significant decline in frequency of panic attacks was observed for each treatment modality. SSRI and CBT+SSRI were associated with a significant faster rate of improvement as compared to COT. Gains were maintained after tapering medication. For patients with moderate or severe AG, CBT+SSRI was associated with a more rapid improvement on panic frequency as compared to patients receiving either mono-treatment.Limitations: Frequency of panic attacks was not assessed beyond the full year of treatment. Second, only one process variable was used.Conclusions: Patients with PD respond well to each treatment as indicated by a significant decline in panic attacks. CBT is associated with a slower rate of improvement as compared to SSRI and CBT+SSRI. Discontinuation of SSRI treatment does not result in a revival of frequency of panic attacks. Our data suggest that for patients without or with only mild AG, SSRI-only will suffice. For patients with moderate or severe AG, the combined CBT+SSRI treatment is recommended. (C) 2013 Elsevier B.V. All rights reserved.",
keywords = "Panic disorder, Agoraphobia, Randomized controlled trials, Cognitive behavioral therapy, Drug treatment, Panic attacks, Rate of improvement, Process study, ANXIETY, TRIAL, PHARMACOTHERAPY, PSYCHOTHERAPY, COMBINATION, FLUVOXAMINE, IMIPRAMINE, PLACEBO, CBT",
author = "{Van Apeldoorn}, {Franske J.} and {Van Hout}, {Wiljo J. P. J.} and Timmerman, {Marieke E.} and Mersch, {Peter Paul A.} and {den Boer}, {Johan A.}",
year = "2013",
month = "9",
day = "5",
doi = "10.1016/j.jad.2013.04.012",
language = "English",
volume = "150",
pages = "313--319",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "ELSEVIER SCIENCE BV",
number = "2",

}

RIS

TY - JOUR

T1 - Rate of improvement during and across three treatments for panic disorder with or without agoraphobia

T2 - Cognitive behavioral therapy, selective serotonin reuptake inhibitor or both combined

AU - Van Apeldoorn, Franske J.

AU - Van Hout, Wiljo J. P. J.

AU - Timmerman, Marieke E.

AU - Mersch, Peter Paul A.

AU - den Boer, Johan A.

PY - 2013/9/5

Y1 - 2013/9/5

N2 - Background: Existing literature on panic disorder (PD) yields no data regarding the differential rates of improvement during Cognitive Behavioral Therapy (CBT), Selective Serotonin Reuptake Inhibitor (SSRI) or both combined (CBT+SSRI).Method: Patients were randomized to CBT, SSRI or CBT+SSRI which each lasted one year including three months of medication taper. Participating patients kept record of the frequency of panic attacks throughout the full year of treatment. Rate of improvement on panic frequency and the relationship between rate of improvement and baseline agoraphobia (AG) were examined.Results: A significant decline in frequency of panic attacks was observed for each treatment modality. SSRI and CBT+SSRI were associated with a significant faster rate of improvement as compared to COT. Gains were maintained after tapering medication. For patients with moderate or severe AG, CBT+SSRI was associated with a more rapid improvement on panic frequency as compared to patients receiving either mono-treatment.Limitations: Frequency of panic attacks was not assessed beyond the full year of treatment. Second, only one process variable was used.Conclusions: Patients with PD respond well to each treatment as indicated by a significant decline in panic attacks. CBT is associated with a slower rate of improvement as compared to SSRI and CBT+SSRI. Discontinuation of SSRI treatment does not result in a revival of frequency of panic attacks. Our data suggest that for patients without or with only mild AG, SSRI-only will suffice. For patients with moderate or severe AG, the combined CBT+SSRI treatment is recommended. (C) 2013 Elsevier B.V. All rights reserved.

AB - Background: Existing literature on panic disorder (PD) yields no data regarding the differential rates of improvement during Cognitive Behavioral Therapy (CBT), Selective Serotonin Reuptake Inhibitor (SSRI) or both combined (CBT+SSRI).Method: Patients were randomized to CBT, SSRI or CBT+SSRI which each lasted one year including three months of medication taper. Participating patients kept record of the frequency of panic attacks throughout the full year of treatment. Rate of improvement on panic frequency and the relationship between rate of improvement and baseline agoraphobia (AG) were examined.Results: A significant decline in frequency of panic attacks was observed for each treatment modality. SSRI and CBT+SSRI were associated with a significant faster rate of improvement as compared to COT. Gains were maintained after tapering medication. For patients with moderate or severe AG, CBT+SSRI was associated with a more rapid improvement on panic frequency as compared to patients receiving either mono-treatment.Limitations: Frequency of panic attacks was not assessed beyond the full year of treatment. Second, only one process variable was used.Conclusions: Patients with PD respond well to each treatment as indicated by a significant decline in panic attacks. CBT is associated with a slower rate of improvement as compared to SSRI and CBT+SSRI. Discontinuation of SSRI treatment does not result in a revival of frequency of panic attacks. Our data suggest that for patients without or with only mild AG, SSRI-only will suffice. For patients with moderate or severe AG, the combined CBT+SSRI treatment is recommended. (C) 2013 Elsevier B.V. All rights reserved.

KW - Panic disorder

KW - Agoraphobia

KW - Randomized controlled trials

KW - Cognitive behavioral therapy

KW - Drug treatment

KW - Panic attacks

KW - Rate of improvement

KW - Process study

KW - ANXIETY

KW - TRIAL

KW - PHARMACOTHERAPY

KW - PSYCHOTHERAPY

KW - COMBINATION

KW - FLUVOXAMINE

KW - IMIPRAMINE

KW - PLACEBO

KW - CBT

U2 - 10.1016/j.jad.2013.04.012

DO - 10.1016/j.jad.2013.04.012

M3 - Article

VL - 150

SP - 313

EP - 319

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 2

ER -

ID: 5940382