Publication

Rapid approach to complex boronic acids

Neochoritis, C. G., Shaabani, S., Ahmadianmoghaddam, M., Zarganes-Tzitzikas, T., Gao, L., Novotná, M., Mitríková, T., Romero, A. R., Irianti, M. I., Xu, R., Olechno, J., Ellson, R., Helan, V., Kossenjans, M., Groves, M. R. & Dömling, A., 3-Jul-2019, In : Science Advances. 5, 7, p. eaaw4607

Research output: Contribution to journalArticleAcademicpeer-review

APA

Neochoritis, C. G., Shaabani, S., Ahmadianmoghaddam, M., Zarganes-Tzitzikas, T., Gao, L., Novotná, M., ... Dömling, A. (2019). Rapid approach to complex boronic acids. Science Advances, 5(7), eaaw4607. https://doi.org/10.1126/sciadv.aaw4607

Author

Neochoritis, Constantinos G ; Shaabani, Shabnam ; Ahmadianmoghaddam, Maryam ; Zarganes-Tzitzikas, Tryfon ; Gao, Li ; Novotná, Michaela ; Mitríková, Tatiana ; Romero, Atilio Reyes ; Irianti, Marina Ika ; Xu, Ruixue ; Olechno, Joe ; Ellson, Richard ; Helan, Victoria ; Kossenjans, Michael ; Groves, Matthew R ; Dömling, Alexander. / Rapid approach to complex boronic acids. In: Science Advances. 2019 ; Vol. 5, No. 7. pp. eaaw4607.

Harvard

Neochoritis, CG, Shaabani, S, Ahmadianmoghaddam, M, Zarganes-Tzitzikas, T, Gao, L, Novotná, M, Mitríková, T, Romero, AR, Irianti, MI, Xu, R, Olechno, J, Ellson, R, Helan, V, Kossenjans, M, Groves, MR & Dömling, A 2019, 'Rapid approach to complex boronic acids', Science Advances, vol. 5, no. 7, pp. eaaw4607. https://doi.org/10.1126/sciadv.aaw4607

Standard

Rapid approach to complex boronic acids. / Neochoritis, Constantinos G; Shaabani, Shabnam; Ahmadianmoghaddam, Maryam; Zarganes-Tzitzikas, Tryfon; Gao, Li; Novotná, Michaela; Mitríková, Tatiana; Romero, Atilio Reyes; Irianti, Marina Ika; Xu, Ruixue; Olechno, Joe; Ellson, Richard; Helan, Victoria; Kossenjans, Michael; Groves, Matthew R; Dömling, Alexander.

In: Science Advances, Vol. 5, No. 7, 03.07.2019, p. eaaw4607.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Neochoritis CG, Shaabani S, Ahmadianmoghaddam M, Zarganes-Tzitzikas T, Gao L, Novotná M et al. Rapid approach to complex boronic acids. Science Advances. 2019 Jul 3;5(7):eaaw4607. https://doi.org/10.1126/sciadv.aaw4607


BibTeX

@article{644b135a3fee4596ad8271b517008542,
title = "Rapid approach to complex boronic acids",
abstract = "The compatibility of free boronic acid building blocks in multicomponent reactions to readily create large libraries of diverse and complex small molecules was investigated. Traditionally, boronic acid synthesis is sequential, synthetically demanding, and time-consuming, which leads to high target synthesis times and low coverage of the boronic acid chemical space. We have performed the synthesis of large libraries of boronic acid derivatives based on multiple chemistries and building blocks using acoustic dispensing technology. The synthesis was performed on a nanomole scale with high synthesis success rates. The discovery of a protease inhibitor underscores the usefulness of the approach. Our acoustic dispensing-enabled chemistry paves the way to highly accelerated synthesis and miniaturized reaction scouting, allowing access to unprecedented boronic acid libraries.",
author = "Neochoritis, {Constantinos G} and Shabnam Shaabani and Maryam Ahmadianmoghaddam and Tryfon Zarganes-Tzitzikas and Li Gao and Michaela Novotn{\'a} and Tatiana Mitr{\'i}kov{\'a} and Romero, {Atilio Reyes} and Irianti, {Marina Ika} and Ruixue Xu and Joe Olechno and Richard Ellson and Victoria Helan and Michael Kossenjans and Groves, {Matthew R} and Alexander D{\"o}mling",
year = "2019",
month = "7",
day = "3",
doi = "10.1126/sciadv.aaw4607",
language = "English",
volume = "5",
pages = "eaaw4607",
journal = "Science Advances",
issn = "2375-2548",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "7",

}

RIS

TY - JOUR

T1 - Rapid approach to complex boronic acids

AU - Neochoritis, Constantinos G

AU - Shaabani, Shabnam

AU - Ahmadianmoghaddam, Maryam

AU - Zarganes-Tzitzikas, Tryfon

AU - Gao, Li

AU - Novotná, Michaela

AU - Mitríková, Tatiana

AU - Romero, Atilio Reyes

AU - Irianti, Marina Ika

AU - Xu, Ruixue

AU - Olechno, Joe

AU - Ellson, Richard

AU - Helan, Victoria

AU - Kossenjans, Michael

AU - Groves, Matthew R

AU - Dömling, Alexander

PY - 2019/7/3

Y1 - 2019/7/3

N2 - The compatibility of free boronic acid building blocks in multicomponent reactions to readily create large libraries of diverse and complex small molecules was investigated. Traditionally, boronic acid synthesis is sequential, synthetically demanding, and time-consuming, which leads to high target synthesis times and low coverage of the boronic acid chemical space. We have performed the synthesis of large libraries of boronic acid derivatives based on multiple chemistries and building blocks using acoustic dispensing technology. The synthesis was performed on a nanomole scale with high synthesis success rates. The discovery of a protease inhibitor underscores the usefulness of the approach. Our acoustic dispensing-enabled chemistry paves the way to highly accelerated synthesis and miniaturized reaction scouting, allowing access to unprecedented boronic acid libraries.

AB - The compatibility of free boronic acid building blocks in multicomponent reactions to readily create large libraries of diverse and complex small molecules was investigated. Traditionally, boronic acid synthesis is sequential, synthetically demanding, and time-consuming, which leads to high target synthesis times and low coverage of the boronic acid chemical space. We have performed the synthesis of large libraries of boronic acid derivatives based on multiple chemistries and building blocks using acoustic dispensing technology. The synthesis was performed on a nanomole scale with high synthesis success rates. The discovery of a protease inhibitor underscores the usefulness of the approach. Our acoustic dispensing-enabled chemistry paves the way to highly accelerated synthesis and miniaturized reaction scouting, allowing access to unprecedented boronic acid libraries.

U2 - 10.1126/sciadv.aaw4607

DO - 10.1126/sciadv.aaw4607

M3 - Article

VL - 5

SP - eaaw4607

JO - Science Advances

JF - Science Advances

SN - 2375-2548

IS - 7

ER -

ID: 92367341