Publication

Randomized Trial of Miniaturized Versus Standard Extracorporeal Circulation in Aortic Valve Surgery

Halfwerk, F. R., Knol, K., Mariani, S., Grandjean, J. G. & Mecozzi, G., Jul-2019, In : Annals of thoracic surgery. 108, 1, p. 37-44 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Halfwerk, F. R., Knol, K., Mariani, S., Grandjean, J. G., & Mecozzi, G. (2019). Randomized Trial of Miniaturized Versus Standard Extracorporeal Circulation in Aortic Valve Surgery. Annals of thoracic surgery, 108(1), 37-44. https://doi.org/10.1016/j.athoracsur.2019.01.019

Author

Halfwerk, Frank R. ; Knol, Kees ; Mariani, Silvia ; Grandjean, Jan G. ; Mecozzi, Gianclaudio. / Randomized Trial of Miniaturized Versus Standard Extracorporeal Circulation in Aortic Valve Surgery. In: Annals of thoracic surgery. 2019 ; Vol. 108, No. 1. pp. 37-44.

Harvard

Halfwerk, FR, Knol, K, Mariani, S, Grandjean, JG & Mecozzi, G 2019, 'Randomized Trial of Miniaturized Versus Standard Extracorporeal Circulation in Aortic Valve Surgery', Annals of thoracic surgery, vol. 108, no. 1, pp. 37-44. https://doi.org/10.1016/j.athoracsur.2019.01.019

Standard

Randomized Trial of Miniaturized Versus Standard Extracorporeal Circulation in Aortic Valve Surgery. / Halfwerk, Frank R.; Knol, Kees; Mariani, Silvia; Grandjean, Jan G.; Mecozzi, Gianclaudio.

In: Annals of thoracic surgery, Vol. 108, No. 1, 07.2019, p. 37-44.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Halfwerk FR, Knol K, Mariani S, Grandjean JG, Mecozzi G. Randomized Trial of Miniaturized Versus Standard Extracorporeal Circulation in Aortic Valve Surgery. Annals of thoracic surgery. 2019 Jul;108(1):37-44. https://doi.org/10.1016/j.athoracsur.2019.01.019


BibTeX

@article{2207327b793c4b6196129adb65df4b5d,
title = "Randomized Trial of Miniaturized Versus Standard Extracorporeal Circulation in Aortic Valve Surgery",
abstract = "Background. Complications related to extracorporeal circulation remain serious. Although a minimal invasive extra corporeal circulation (MiECC) system was developed to cope with these complications, its effectivity on patient-related outcomes such as blood loss remain uncertain. Therefore, the aim of this study is to compare MiECC to an advanced standard system with respect to blood loss.Methods. A total of 128 adult patients undergoing elective isolated aortic valve replacement were enrolled in a randomized clinical trial. Patients who had undergone previous heart surgery and with preexisting kidney failure were excluded. The primary end point was postoperative blood loss after 12 hours and at drain removal. Secondary end points included intensive care and total length of stay and intubation time. At 1 hour and 12 hours after surgery, clinical laboratory data were determined. Early clinical outcomes and long-term survival were determined.Results. MiECC patients (n = 63) had a significant lower blood loss (230 mL, 95{\%} confidence interval: 203 to 261 mL) than regular patients (n = 62) after 12 hours (288 mL, 95{\%} confidence interval: 241 to 344 mL, p = 0.04). A preservation of hemoglobin levels 1 hour and 12 hours after surgery in the MiECC group were observed (p <0.001). No difference was found in early clinical outcomes and long-term survival.Conclusions. This randomized controlled trial compares MiECC and an advanced system for aortic valve replacement with blood loss as primary end point. We conclude that using MiECC is clinically equal for short- and long-term follow-up regarding blood loss. (C) 2019 by The Society of Thoracic Surgeons",
keywords = "CARDIAC-SURGERY, CARDIOPULMONARY BYPASS, REPLACEMENT, METAANALYSIS, SOCIETY",
author = "Halfwerk, {Frank R.} and Kees Knol and Silvia Mariani and Grandjean, {Jan G.} and Gianclaudio Mecozzi",
year = "2019",
month = "7",
doi = "10.1016/j.athoracsur.2019.01.019",
language = "English",
volume = "108",
pages = "37--44",
journal = "Annals of thoracic surgery",
issn = "0003-4975",
publisher = "ELSEVIER SCIENCE INC",
number = "1",

}

RIS

TY - JOUR

T1 - Randomized Trial of Miniaturized Versus Standard Extracorporeal Circulation in Aortic Valve Surgery

AU - Halfwerk, Frank R.

AU - Knol, Kees

AU - Mariani, Silvia

AU - Grandjean, Jan G.

AU - Mecozzi, Gianclaudio

PY - 2019/7

Y1 - 2019/7

N2 - Background. Complications related to extracorporeal circulation remain serious. Although a minimal invasive extra corporeal circulation (MiECC) system was developed to cope with these complications, its effectivity on patient-related outcomes such as blood loss remain uncertain. Therefore, the aim of this study is to compare MiECC to an advanced standard system with respect to blood loss.Methods. A total of 128 adult patients undergoing elective isolated aortic valve replacement were enrolled in a randomized clinical trial. Patients who had undergone previous heart surgery and with preexisting kidney failure were excluded. The primary end point was postoperative blood loss after 12 hours and at drain removal. Secondary end points included intensive care and total length of stay and intubation time. At 1 hour and 12 hours after surgery, clinical laboratory data were determined. Early clinical outcomes and long-term survival were determined.Results. MiECC patients (n = 63) had a significant lower blood loss (230 mL, 95% confidence interval: 203 to 261 mL) than regular patients (n = 62) after 12 hours (288 mL, 95% confidence interval: 241 to 344 mL, p = 0.04). A preservation of hemoglobin levels 1 hour and 12 hours after surgery in the MiECC group were observed (p <0.001). No difference was found in early clinical outcomes and long-term survival.Conclusions. This randomized controlled trial compares MiECC and an advanced system for aortic valve replacement with blood loss as primary end point. We conclude that using MiECC is clinically equal for short- and long-term follow-up regarding blood loss. (C) 2019 by The Society of Thoracic Surgeons

AB - Background. Complications related to extracorporeal circulation remain serious. Although a minimal invasive extra corporeal circulation (MiECC) system was developed to cope with these complications, its effectivity on patient-related outcomes such as blood loss remain uncertain. Therefore, the aim of this study is to compare MiECC to an advanced standard system with respect to blood loss.Methods. A total of 128 adult patients undergoing elective isolated aortic valve replacement were enrolled in a randomized clinical trial. Patients who had undergone previous heart surgery and with preexisting kidney failure were excluded. The primary end point was postoperative blood loss after 12 hours and at drain removal. Secondary end points included intensive care and total length of stay and intubation time. At 1 hour and 12 hours after surgery, clinical laboratory data were determined. Early clinical outcomes and long-term survival were determined.Results. MiECC patients (n = 63) had a significant lower blood loss (230 mL, 95% confidence interval: 203 to 261 mL) than regular patients (n = 62) after 12 hours (288 mL, 95% confidence interval: 241 to 344 mL, p = 0.04). A preservation of hemoglobin levels 1 hour and 12 hours after surgery in the MiECC group were observed (p <0.001). No difference was found in early clinical outcomes and long-term survival.Conclusions. This randomized controlled trial compares MiECC and an advanced system for aortic valve replacement with blood loss as primary end point. We conclude that using MiECC is clinically equal for short- and long-term follow-up regarding blood loss. (C) 2019 by The Society of Thoracic Surgeons

KW - CARDIAC-SURGERY

KW - CARDIOPULMONARY BYPASS

KW - REPLACEMENT

KW - METAANALYSIS

KW - SOCIETY

U2 - 10.1016/j.athoracsur.2019.01.019

DO - 10.1016/j.athoracsur.2019.01.019

M3 - Article

VL - 108

SP - 37

EP - 44

JO - Annals of thoracic surgery

JF - Annals of thoracic surgery

SN - 0003-4975

IS - 1

ER -

ID: 95846829