Randomised Comparison of Costs and Cost-Effectiveness of Cryostripping and Endovenous Laser Ablation for Varicose Veins: 2-Year Results

Disselhoff, B. C. V. M., Buskens, E., Kelder, J. C., Kinderen, D. J. D. & Moll, F. L., Mar-2009, In : European Journal of Vascular and Endovascular Surgery. 37, 3, p. 357-363 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • B. C. V. M. Disselhoff
  • E. Buskens
  • J. C. Kelder
  • D. J. der Kinderen
  • F. L. Moll

Background: Although endovenous laser ablation for varicose veins is replacing surgical stripping, proper economic evaluation with adequate follow-up in a randomised clinical trial is important for considered policy decisions regarding the implementation of new techniques.

Methods: Data from a randomised controlled trial comparing cryostripping and endovenous laser ablation in 120 patients were combined to study Short Form (SF) 6D outcome, costs and cost-effectiveness 2 years after treatment. Incremental cost per quality-adjusted life year (QALY) gained 2 years after treatment was calculated using different strategies, and uncertainty was assessed with bootstrapping.

Results: Over the total study period, mean SF-6D scores improved slightly from 0.78 at baseline to 0.80 at 2 years for patients who underwent cryostripping and from 0.77 to 0.79 for patients who underwent endovenous laser. QALY (SF-6D) was 1.59 in patients who underwent cryostripping and 1.60 in patients who underwent endovenous laser 2 years after treatment. The costs of cryostripping and endovenous laser per patient were (sic)2651 and (sic)2783, respectively. Bootstrapping indicated that cryostripping was associated with an incremental cost-effectiveness ratio of (sic)32 per QALY gained. With regard to different strategies, outpatient cryostripping was less costly and more effective 2 years after treatment.

Conclusion: In this study, in terms of costs per QALY gained, outpatient cryostripping appeared to be the dominant strategy, but endovenous laser yielded comparable outcomes for a relatively little additional cost. (C) 2008 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)357-363
Number of pages7
JournalEuropean Journal of Vascular and Endovascular Surgery
Issue number3
Publication statusPublished - Mar-2009


  • Endovenous laser, Cryostripping, Costs and cost-effectiveness, SAPHENOUS-VEIN, TRIAL, DISEASE, LONG

ID: 4879361