Publication

Rafts in oligodendrocytes: Evidence and structure-function relationship

Gielen, E., Baron, W., Vandeven, M., Steels, P., Hoekstra, D. & Ameloot, M., 1-Nov-2006, In : Glia. 54, 6, p. 499-512 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Gielen, E., Baron, W., Vandeven, M., Steels, P., Hoekstra, D., & Ameloot, M. (2006). Rafts in oligodendrocytes: Evidence and structure-function relationship. Glia, 54(6), 499-512. https://doi.org/10.1002/glia.20406

Author

Gielen, Ellen ; Baron, Wia ; Vandeven, Martin ; Steels, Paul ; Hoekstra, Dick ; Ameloot, Marcel. / Rafts in oligodendrocytes : Evidence and structure-function relationship. In: Glia. 2006 ; Vol. 54, No. 6. pp. 499-512.

Harvard

Gielen, E, Baron, W, Vandeven, M, Steels, P, Hoekstra, D & Ameloot, M 2006, 'Rafts in oligodendrocytes: Evidence and structure-function relationship', Glia, vol. 54, no. 6, pp. 499-512. https://doi.org/10.1002/glia.20406

Standard

Rafts in oligodendrocytes : Evidence and structure-function relationship. / Gielen, Ellen; Baron, Wia; Vandeven, Martin; Steels, Paul; Hoekstra, Dick; Ameloot, Marcel.

In: Glia, Vol. 54, No. 6, 01.11.2006, p. 499-512.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Gielen E, Baron W, Vandeven M, Steels P, Hoekstra D, Ameloot M. Rafts in oligodendrocytes: Evidence and structure-function relationship. Glia. 2006 Nov 1;54(6):499-512. https://doi.org/10.1002/glia.20406


BibTeX

@article{c76b6adc82584635b8b4f3df9b19f81e,
title = "Rafts in oligodendrocytes: Evidence and structure-function relationship",
abstract = "The plasma membrane of eukaryotic cells exhibits lateral inhomogeneities, mainly containing cholesterol and sphingomyelin, which provide liquid-ordered microdomains (lipid {"}rafts{"}) that segregate membrane components. Rafts are thought to modulate the biological functions of molecules that become associated with them, and as such, they appear to be involved in a variety of processes, including signal transduction, membrane sorting, cell adhesion and pathogen entry. Although still a matter of ongoing debate, evidence in favor of the presence of these microdomains is gradually accumulating but a consensus on issues like their size, lifetime, composition, and biological significance has yet to be reached. Here, we provide an overview of the evidence supporting the presence of rafts in oligodendrocytes, the myelin-producing cells of the central nervous system, and discuss their functional significance. the myelin membrane differs fundamentally from the plasma membrane, both in lipid and protein composition. Moreover, since myelin membranes are unusually enriched in glycosphingolipids, questions concerning the biogenesis and functional relevance of microdomains thus appear of special interest in oligodendrocytes. The current picture of rafts in oligodendrocytes is mainly based on detergent methods. The robustness of such data is discussed and alternative methods that may provide complementary data are indicated. (c) 2006 Wiley-Liss, Inc.",
keywords = "myelin, microdomains, confined diffusion, axon-glial interaction, MYELIN-ASSOCIATED GLYCOPROTEIN, CENTRAL-NERVOUS-SYSTEM, GPI-ANCHORED PROTEINS, RESONANCE ENERGY-TRANSFER, FLUORESCENCE CORRELATION SPECTROSCOPY, DARBY CANINE KIDNEY, FYN TYROSINE KINASE, SCANNING OPTICAL MICROSCOPY, GROWTH-FACTOR INTERACTIONS, ATOMIC-FORCE MICROSCOPY",
author = "Ellen Gielen and Wia Baron and Martin Vandeven and Paul Steels and Dick Hoekstra and Marcel Ameloot",
year = "2006",
month = nov,
day = "1",
doi = "10.1002/glia.20406",
language = "English",
volume = "54",
pages = "499--512",
journal = "Glia",
issn = "0894-1491",
publisher = "Wiley",
number = "6",

}

RIS

TY - JOUR

T1 - Rafts in oligodendrocytes

T2 - Evidence and structure-function relationship

AU - Gielen, Ellen

AU - Baron, Wia

AU - Vandeven, Martin

AU - Steels, Paul

AU - Hoekstra, Dick

AU - Ameloot, Marcel

PY - 2006/11/1

Y1 - 2006/11/1

N2 - The plasma membrane of eukaryotic cells exhibits lateral inhomogeneities, mainly containing cholesterol and sphingomyelin, which provide liquid-ordered microdomains (lipid "rafts") that segregate membrane components. Rafts are thought to modulate the biological functions of molecules that become associated with them, and as such, they appear to be involved in a variety of processes, including signal transduction, membrane sorting, cell adhesion and pathogen entry. Although still a matter of ongoing debate, evidence in favor of the presence of these microdomains is gradually accumulating but a consensus on issues like their size, lifetime, composition, and biological significance has yet to be reached. Here, we provide an overview of the evidence supporting the presence of rafts in oligodendrocytes, the myelin-producing cells of the central nervous system, and discuss their functional significance. the myelin membrane differs fundamentally from the plasma membrane, both in lipid and protein composition. Moreover, since myelin membranes are unusually enriched in glycosphingolipids, questions concerning the biogenesis and functional relevance of microdomains thus appear of special interest in oligodendrocytes. The current picture of rafts in oligodendrocytes is mainly based on detergent methods. The robustness of such data is discussed and alternative methods that may provide complementary data are indicated. (c) 2006 Wiley-Liss, Inc.

AB - The plasma membrane of eukaryotic cells exhibits lateral inhomogeneities, mainly containing cholesterol and sphingomyelin, which provide liquid-ordered microdomains (lipid "rafts") that segregate membrane components. Rafts are thought to modulate the biological functions of molecules that become associated with them, and as such, they appear to be involved in a variety of processes, including signal transduction, membrane sorting, cell adhesion and pathogen entry. Although still a matter of ongoing debate, evidence in favor of the presence of these microdomains is gradually accumulating but a consensus on issues like their size, lifetime, composition, and biological significance has yet to be reached. Here, we provide an overview of the evidence supporting the presence of rafts in oligodendrocytes, the myelin-producing cells of the central nervous system, and discuss their functional significance. the myelin membrane differs fundamentally from the plasma membrane, both in lipid and protein composition. Moreover, since myelin membranes are unusually enriched in glycosphingolipids, questions concerning the biogenesis and functional relevance of microdomains thus appear of special interest in oligodendrocytes. The current picture of rafts in oligodendrocytes is mainly based on detergent methods. The robustness of such data is discussed and alternative methods that may provide complementary data are indicated. (c) 2006 Wiley-Liss, Inc.

KW - myelin

KW - microdomains

KW - confined diffusion

KW - axon-glial interaction

KW - MYELIN-ASSOCIATED GLYCOPROTEIN

KW - CENTRAL-NERVOUS-SYSTEM

KW - GPI-ANCHORED PROTEINS

KW - RESONANCE ENERGY-TRANSFER

KW - FLUORESCENCE CORRELATION SPECTROSCOPY

KW - DARBY CANINE KIDNEY

KW - FYN TYROSINE KINASE

KW - SCANNING OPTICAL MICROSCOPY

KW - GROWTH-FACTOR INTERACTIONS

KW - ATOMIC-FORCE MICROSCOPY

U2 - 10.1002/glia.20406

DO - 10.1002/glia.20406

M3 - Review article

VL - 54

SP - 499

EP - 512

JO - Glia

JF - Glia

SN - 0894-1491

IS - 6

ER -

ID: 4470173