Publication

Radiographic vertebral fractures develop in patients with ankylosing spondylitis during 4 years of TNF-alpha blocking therapy

Maas, F., Spoorenberg, A., Brouwer, L., Schilder, A. M., Chaudhry, R. N., Wink, F., Bootsma, H., van der Veer, E. & Arends, S., 2016, In : Clinical and Experimental Rheumatology. 34, 2, p. 191-199 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Objective

To determine the prevalence and incidence of radiographic vertebral fractures in ankylosing spondylitis (AS) patients treated with TNF-alpha blocking therapy for 4 years and to explore the relationship with patient characteristics, clinical assessments, radiographic damage, and bone mineral density (BMD).

Methods

This study included consecutive AS patients with active disease from the Groningen Leeuwarden AS (GLAS) cohort treated with TNF-alpha blocking therapy for 4 years and with available thoracic and lumbar radiographs at baseline and at 4 years. Vertebral fractures were assessed by two readers (mild: >= 20-= 25-= 40% reduction in vertebral height).

Results

In 27 of 105 (26%) AS patients, radiographic vertebral fractures were observed at baseline. These patients were significantly older, had larger occiput-to-wall distance, and more spinal radiographic damage. During 4 years of TNF-alpha blocking therapy, 21 (20%) patients developed at least one new fracture. Older age, smoking, higher BASFI, low lumbar spine BMD (Z-score

Conclusion

The prevalence of radiographic vertebral fractures was high in AS patients with active disease. Although clinical assessments and BMD improved significantly, new vertebral fractures still developed during 4 years of TNF-alpha blocking therapy.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalClinical and Experimental Rheumatology
Volume34
Issue number2
Publication statusPublished - 2016

    Keywords

  • ankylosing spondylitis, tumour necrosis factor-alpha blocking therapy, spinal fracture, incidence, bone density, BONE-MINERAL DENSITY, LONGITUDINAL OBSERVATIONAL COHORT, DISEASE-ACTIVITY, HIGH PREVALENCE, RISK, OSTEOPOROSIS, DEFORMITIES, DISCONTINUATION, COMPLICATIONS, HYPERKYPHOSIS

ID: 41255909