Publication

Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence

Moreno-Gámez, S., Sorg, R. A., Domenech, A., Kjos, M., Weissing, F. J., van Doorn, G. S. & Veening, J-W., 10-Nov-2017, In : Nature Communications. 8, 1, 12 p., 854.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Moreno-Gámez, S., Sorg, R. A., Domenech, A., Kjos, M., Weissing, F. J., van Doorn, G. S., & Veening, J-W. (2017). Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence. Nature Communications, 8(1), [854]. https://doi.org/10.1038/s41467-017-00903-y

Author

Moreno-Gámez, Stefany ; Sorg, Robin A ; Domenech, Arnau ; Kjos, Morten ; Weissing, Franz J ; van Doorn, G Sander ; Veening, Jan-Willem. / Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence. In: Nature Communications. 2017 ; Vol. 8, No. 1.

Harvard

Moreno-Gámez, S, Sorg, RA, Domenech, A, Kjos, M, Weissing, FJ, van Doorn, GS & Veening, J-W 2017, 'Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence' Nature Communications, vol. 8, no. 1, 854. https://doi.org/10.1038/s41467-017-00903-y

Standard

Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence. / Moreno-Gámez, Stefany; Sorg, Robin A; Domenech, Arnau; Kjos, Morten; Weissing, Franz J; van Doorn, G Sander; Veening, Jan-Willem.

In: Nature Communications, Vol. 8, No. 1, 854, 10.11.2017.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Moreno-Gámez S, Sorg RA, Domenech A, Kjos M, Weissing FJ, van Doorn GS et al. Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence. Nature Communications. 2017 Nov 10;8(1). 854. https://doi.org/10.1038/s41467-017-00903-y


BibTeX

@article{36a27a75d5de463d9c39b72a5b5cd3c0,
title = "Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence",
abstract = "Streptococcus pneumoniae becomes competent for genetic transformation when exposed to an autoinducer peptide known as competence-stimulating peptide (CSP). This peptide was originally described as a quorum-sensing signal, enabling individual cells to regulate competence in response to population density. However, recent studies suggest that CSP may instead serve as a probe for sensing environmental cues, such as antibiotic stress or environmental diffusion. Here, we show that competence induction can be simultaneously influenced by cell density, external pH, antibiotic-induced stress, and cell history. Our experimental data is explained by a mathematical model where the environment and cell history modify the rate at which cells produce or sense CSP. Taken together, model and experiments indicate that autoinducer concentration can function as an indicator of cell density across environmental conditions, while also incorporating information on environmental factors or cell history, allowing cells to integrate cues such as antibiotic stress into their quorum-sensing response. This unifying perspective may apply to other debated quorum-sensing systems.Peptide CSP regulates natural competence in pneumococci and has been proposed as a quorum-sensing signal or a probe for sensing environmental cues. Here, the authors show that CSP levels can indeed act as an indicator of cell density and also incorporate information on environmental factors or cell history.",
keywords = "Journal Article",
author = "Stefany Moreno-G{\'a}mez and Sorg, {Robin A} and Arnau Domenech and Morten Kjos and Weissing, {Franz J} and {van Doorn}, {G Sander} and Jan-Willem Veening",
year = "2017",
month = "11",
day = "10",
doi = "10.1038/s41467-017-00903-y",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence

AU - Moreno-Gámez, Stefany

AU - Sorg, Robin A

AU - Domenech, Arnau

AU - Kjos, Morten

AU - Weissing, Franz J

AU - van Doorn, G Sander

AU - Veening, Jan-Willem

PY - 2017/11/10

Y1 - 2017/11/10

N2 - Streptococcus pneumoniae becomes competent for genetic transformation when exposed to an autoinducer peptide known as competence-stimulating peptide (CSP). This peptide was originally described as a quorum-sensing signal, enabling individual cells to regulate competence in response to population density. However, recent studies suggest that CSP may instead serve as a probe for sensing environmental cues, such as antibiotic stress or environmental diffusion. Here, we show that competence induction can be simultaneously influenced by cell density, external pH, antibiotic-induced stress, and cell history. Our experimental data is explained by a mathematical model where the environment and cell history modify the rate at which cells produce or sense CSP. Taken together, model and experiments indicate that autoinducer concentration can function as an indicator of cell density across environmental conditions, while also incorporating information on environmental factors or cell history, allowing cells to integrate cues such as antibiotic stress into their quorum-sensing response. This unifying perspective may apply to other debated quorum-sensing systems.Peptide CSP regulates natural competence in pneumococci and has been proposed as a quorum-sensing signal or a probe for sensing environmental cues. Here, the authors show that CSP levels can indeed act as an indicator of cell density and also incorporate information on environmental factors or cell history.

AB - Streptococcus pneumoniae becomes competent for genetic transformation when exposed to an autoinducer peptide known as competence-stimulating peptide (CSP). This peptide was originally described as a quorum-sensing signal, enabling individual cells to regulate competence in response to population density. However, recent studies suggest that CSP may instead serve as a probe for sensing environmental cues, such as antibiotic stress or environmental diffusion. Here, we show that competence induction can be simultaneously influenced by cell density, external pH, antibiotic-induced stress, and cell history. Our experimental data is explained by a mathematical model where the environment and cell history modify the rate at which cells produce or sense CSP. Taken together, model and experiments indicate that autoinducer concentration can function as an indicator of cell density across environmental conditions, while also incorporating information on environmental factors or cell history, allowing cells to integrate cues such as antibiotic stress into their quorum-sensing response. This unifying perspective may apply to other debated quorum-sensing systems.Peptide CSP regulates natural competence in pneumococci and has been proposed as a quorum-sensing signal or a probe for sensing environmental cues. Here, the authors show that CSP levels can indeed act as an indicator of cell density and also incorporate information on environmental factors or cell history.

KW - Journal Article

U2 - 10.1038/s41467-017-00903-y

DO - 10.1038/s41467-017-00903-y

M3 - Article

VL - 8

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 854

ER -

ID: 49013450