Publication

Quantitative analysis of organelle abundance, morphology and dynamics

van Zutphen, T. & van der Klei, I. J., Feb-2011, In : Current Opinion in Biotechnology. 22, 1, p. 127-132 6 p.

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Recent data indicate that morphological characteristics of cell organelles are important for their function in the cell. These characteristics include not only their shape, number and size, but also their distribution in the cell. Moreover, the dynamics of processes that result in changes in these characteristics (e.g. organelle fission, fusion, autophagy, transport) influence the function of the cell.

For a better understanding of these processes quantitative approaches are important. Here we give an overview of contemporary biochemical and microscopy methods that are used to quantify organelle abundance, morphology and the kinetics of the processes that cause changes in these properties.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalCurrent Opinion in Biotechnology
Volume22
Issue number1
Publication statusPublished - Feb-2011

    Keywords

  • FLUORESCENCE CORRELATION SPECTROSCOPY, YEAST, AUTOPHAGY, PROTEIN, MICROSCOPY, INHIBITION, COMPLEX, ASSAYS

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