Publication

Quantifying effects of radiotherapy-induced microvascular injury; review of established and emerging brain MRI techniques

Kłos, J., van Laar, P. J., Sinnige, P. F., Enting, R. H., Kramer, M. C. A., van der Weide, H. L., van Buchem, M. A., Dierckx, R. A. J. O., Borra, R. J. H. & van der Hoorn, A., 5-Nov-2019, In : Radiotherapy and Oncology. 140, p. 41-53 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Kłos, J., van Laar, P. J., Sinnige, P. F., Enting, R. H., Kramer, M. C. A., van der Weide, H. L., ... van der Hoorn, A. (2019). Quantifying effects of radiotherapy-induced microvascular injury; review of established and emerging brain MRI techniques. Radiotherapy and Oncology, 140, 41-53. https://doi.org/10.1016/j.radonc.2019.05.020

Author

Kłos, Justyna ; van Laar, Peter Jan ; Sinnige, Peter F ; Enting, Roelien H ; Kramer, Miranda C A ; van der Weide, Hiske L ; van Buchem, Mark A ; Dierckx, Rudi A J O ; Borra, Ronald J H ; van der Hoorn, Anouk. / Quantifying effects of radiotherapy-induced microvascular injury; review of established and emerging brain MRI techniques. In: Radiotherapy and Oncology. 2019 ; Vol. 140. pp. 41-53.

Harvard

Kłos, J, van Laar, PJ, Sinnige, PF, Enting, RH, Kramer, MCA, van der Weide, HL, van Buchem, MA, Dierckx, RAJO, Borra, RJH & van der Hoorn, A 2019, 'Quantifying effects of radiotherapy-induced microvascular injury; review of established and emerging brain MRI techniques', Radiotherapy and Oncology, vol. 140, pp. 41-53. https://doi.org/10.1016/j.radonc.2019.05.020

Standard

Quantifying effects of radiotherapy-induced microvascular injury; review of established and emerging brain MRI techniques. / Kłos, Justyna; van Laar, Peter Jan; Sinnige, Peter F; Enting, Roelien H; Kramer, Miranda C A; van der Weide, Hiske L; van Buchem, Mark A; Dierckx, Rudi A J O; Borra, Ronald J H; van der Hoorn, Anouk.

In: Radiotherapy and Oncology, Vol. 140, 05.11.2019, p. 41-53.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Kłos J, van Laar PJ, Sinnige PF, Enting RH, Kramer MCA, van der Weide HL et al. Quantifying effects of radiotherapy-induced microvascular injury; review of established and emerging brain MRI techniques. Radiotherapy and Oncology. 2019 Nov 5;140:41-53. https://doi.org/10.1016/j.radonc.2019.05.020


BibTeX

@article{a6ef0e2ec6834d0ba656968ce6d9092d,
title = "Quantifying effects of radiotherapy-induced microvascular injury; review of established and emerging brain MRI techniques",
abstract = "Microvascular changes are increasingly recognised not only as primary drivers of radiotherapy treatment response in brain tumours, but also as an important contributor to short- and long-term (cognitive) side effects arising from irradiation of otherwise healthy brain tissue. As overall survival of patients with brain tumours is increasing, monitoring long-term sequels of radiotherapy-induced microvascular changes in the context of their potential predictive power for outcome, such as cognitive disability, has become increasingly relevant. Ideally, radiotherapy-induced significant microvascular changes in otherwise healthy brain tissue should be identified as early as possible to facilitate adaptive radiotherapy and to proactively start treatment to minimise the influence on these side-effects on the final outcome.Although MRI is already known to be able to detect significant long-term radiotherapy induced microvascular effects, more recently advanced MR imaging biomarkers reflecting microvascular integrity and function have been reported and might provide a more accurate and earlier detection of microvascular changes. However, the use and validation of both established and new techniques in the context of monitoring early and late radiotherapy-induced microvascular changes in both target-tissue and healthy tissue currently are minimal at best.This review aims to summarise the performance and limitations of existing methods and future opportunities for detection and quantification of radiotherapy-induced microvascular changes, as well as the relation of these findings with key clinical parameters. (C) 2019 Elsevier B.V. All rights reserved.",
keywords = "Radiotherapy-induced injury, Susceptibility-weighted imaging (SWI), Quantitative susceptibility mapping (QSM), Dynamic susceptibility contrast MRI (DSC-MRI), Cerebral microbleeds (CMB), Microvascular, SMALL VESSEL DISEASE, WHITE-MATTER LESIONS, CENTRAL-NERVOUS-SYSTEM, CEREBRAL CAVERNOUS MALFORMATIONS, RADIATION-INDUCED CHANGES, LONG-TERM SURVIVORS, LOW-GRADE GLIOMAS, CAPILLARY TELANGIECTASIA, CRANIAL IRRADIATION, BLOOD-VOLUME",
author = "Justyna Kłos and {van Laar}, {Peter Jan} and Sinnige, {Peter F} and Enting, {Roelien H} and Kramer, {Miranda C A} and {van der Weide}, {Hiske L} and {van Buchem}, {Mark A} and Dierckx, {Rudi A J O} and Borra, {Ronald J H} and {van der Hoorn}, Anouk",
note = "Copyright {\circledC} 2019 Elsevier B.V. All rights reserved.",
year = "2019",
month = "11",
day = "5",
doi = "10.1016/j.radonc.2019.05.020",
language = "English",
volume = "140",
pages = "41--53",
journal = "Radiotherapy and Oncology",
issn = "0167-8140",
publisher = "ELSEVIER IRELAND LTD",

}

RIS

TY - JOUR

T1 - Quantifying effects of radiotherapy-induced microvascular injury; review of established and emerging brain MRI techniques

AU - Kłos, Justyna

AU - van Laar, Peter Jan

AU - Sinnige, Peter F

AU - Enting, Roelien H

AU - Kramer, Miranda C A

AU - van der Weide, Hiske L

AU - van Buchem, Mark A

AU - Dierckx, Rudi A J O

AU - Borra, Ronald J H

AU - van der Hoorn, Anouk

N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2019/11/5

Y1 - 2019/11/5

N2 - Microvascular changes are increasingly recognised not only as primary drivers of radiotherapy treatment response in brain tumours, but also as an important contributor to short- and long-term (cognitive) side effects arising from irradiation of otherwise healthy brain tissue. As overall survival of patients with brain tumours is increasing, monitoring long-term sequels of radiotherapy-induced microvascular changes in the context of their potential predictive power for outcome, such as cognitive disability, has become increasingly relevant. Ideally, radiotherapy-induced significant microvascular changes in otherwise healthy brain tissue should be identified as early as possible to facilitate adaptive radiotherapy and to proactively start treatment to minimise the influence on these side-effects on the final outcome.Although MRI is already known to be able to detect significant long-term radiotherapy induced microvascular effects, more recently advanced MR imaging biomarkers reflecting microvascular integrity and function have been reported and might provide a more accurate and earlier detection of microvascular changes. However, the use and validation of both established and new techniques in the context of monitoring early and late radiotherapy-induced microvascular changes in both target-tissue and healthy tissue currently are minimal at best.This review aims to summarise the performance and limitations of existing methods and future opportunities for detection and quantification of radiotherapy-induced microvascular changes, as well as the relation of these findings with key clinical parameters. (C) 2019 Elsevier B.V. All rights reserved.

AB - Microvascular changes are increasingly recognised not only as primary drivers of radiotherapy treatment response in brain tumours, but also as an important contributor to short- and long-term (cognitive) side effects arising from irradiation of otherwise healthy brain tissue. As overall survival of patients with brain tumours is increasing, monitoring long-term sequels of radiotherapy-induced microvascular changes in the context of their potential predictive power for outcome, such as cognitive disability, has become increasingly relevant. Ideally, radiotherapy-induced significant microvascular changes in otherwise healthy brain tissue should be identified as early as possible to facilitate adaptive radiotherapy and to proactively start treatment to minimise the influence on these side-effects on the final outcome.Although MRI is already known to be able to detect significant long-term radiotherapy induced microvascular effects, more recently advanced MR imaging biomarkers reflecting microvascular integrity and function have been reported and might provide a more accurate and earlier detection of microvascular changes. However, the use and validation of both established and new techniques in the context of monitoring early and late radiotherapy-induced microvascular changes in both target-tissue and healthy tissue currently are minimal at best.This review aims to summarise the performance and limitations of existing methods and future opportunities for detection and quantification of radiotherapy-induced microvascular changes, as well as the relation of these findings with key clinical parameters. (C) 2019 Elsevier B.V. All rights reserved.

KW - Radiotherapy-induced injury

KW - Susceptibility-weighted imaging (SWI)

KW - Quantitative susceptibility mapping (QSM)

KW - Dynamic susceptibility contrast MRI (DSC-MRI)

KW - Cerebral microbleeds (CMB)

KW - Microvascular

KW - SMALL VESSEL DISEASE

KW - WHITE-MATTER LESIONS

KW - CENTRAL-NERVOUS-SYSTEM

KW - CEREBRAL CAVERNOUS MALFORMATIONS

KW - RADIATION-INDUCED CHANGES

KW - LONG-TERM SURVIVORS

KW - LOW-GRADE GLIOMAS

KW - CAPILLARY TELANGIECTASIA

KW - CRANIAL IRRADIATION

KW - BLOOD-VOLUME

U2 - 10.1016/j.radonc.2019.05.020

DO - 10.1016/j.radonc.2019.05.020

M3 - Review article

VL - 140

SP - 41

EP - 53

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

ER -

ID: 84872700