Quality of Life of Patients With Recurrent Respiratory Papillomatosis

San Giorgi, M. R. M., Aaltonen, L-M., Rihkanen, H., Tjon Pian Gi, R. E. A., van der Laan, B. F. A. M., Hoekstra-Weebers, J. E. H. M. & Dikkers, F. G., Aug-2017, In : Laryngoscope. 127, 8, p. 1826-1831 6 p.

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  • Quality of life of patients with recurrent respiratory papillomatosis

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OBJECTIVES/HYPOTHESIS: Recurrent respiratory papillomatosis (RRP) is a disease with a high disease burden. Few studies have assessed quality of life (QoL) of RRP patients. This study compares QoL of these patients with controls. Associations between QoL and sociodemographic and illness-related factors are examined, as is uptake of psychosocial care and speech therapy.

STUDY DESIGN: Prospective cross-sectional questionnaire research.

METHODS: Ninety-one RRP patients (response = 67%) from two university hospitals in the Netherlands and Finland completed the following patient reported outcome measures: (HADS), 15-dimensional health-related quality-of-life scale (15D), Voice Handicap Index (VHI) and the RAND 36-item health-related quality-of-life survey instrument (RAND-36) assessing health-related QoL and voice handicap, and they provided sociodemographic, illness-related, and allied healthcare use. Descriptive analyses, χ(2) tests, t tests, analysis of variance tests, and Pearson correlations were computed to describe the study population and to examine differences between groups.

RESULTS: RRP patients had significantly higher mean scores on depression, health-related QoL (15D) and on voice problems (VHI), and significantly lower mean scores on anxiety than controls. Dutch patients had more pain and a decreased general health perception (RAND-36) than controls. Dutch patients and older patients were more depressed, women were more anxious, older patients had lower health-related QoL, and smoking was significantly associated with voice handicap. Patients who had received psychosocial care had significantly higher HADS-depression mean scores than patients who did not receive psychosocial care.

CONCLUSIONS: Having RRP has significant effect on voice-related QoL and depression, but has no negative effect on anxiety and health-related QoL. Risk factors for decreased functioning are different than previously hypothesized by many authors. Prevention should be aimed at these risk factors.

LEVEL OF EVIDENCE: 4. Laryngoscope, 2016.

Original languageEnglish
Pages (from-to)1826-1831
Number of pages6
Issue number8
Early online date15-Nov-2016
Publication statusPublished - Aug-2017


  • Recurrent respiratory papillomatosis, psychosocial distress, quality of life, recurrent respiratory papillomatosis, VOICE-HANDICAP-INDEX, DEPRESSION SCALE, HOSPITAL ANXIETY, DUTCH VERSION, HEALTH-STATUS, QUESTIONNAIRE, ADAPTATION, VALIDATION, THERAPY, ONSET

ID: 37196666