Publication

Quality of life of elderly ischaemic stroke patients one year after thrombolytic therapy. A comparison between patients with and without thrombolytic therapy

de Weerd, L., Luijckx, G-J. R., Groenier, K. H. & van der Meer, K., 26-Jul-2012, In : BMC NEUROLOGY. 12, 9 p., 61.

Research output: Contribution to journalArticleAcademicpeer-review

APA

de Weerd, L., Luijckx, G-J. R., Groenier, K. H., & van der Meer, K. (2012). Quality of life of elderly ischaemic stroke patients one year after thrombolytic therapy. A comparison between patients with and without thrombolytic therapy. BMC NEUROLOGY, 12, [61]. https://doi.org/10.1186/1471-2377-12-61

Author

de Weerd, Leonie ; Luijckx, Gert-Jan R. ; Groenier, Klaas H. ; van der Meer, Klaas. / Quality of life of elderly ischaemic stroke patients one year after thrombolytic therapy. A comparison between patients with and without thrombolytic therapy. In: BMC NEUROLOGY. 2012 ; Vol. 12.

Harvard

de Weerd, L, Luijckx, G-JR, Groenier, KH & van der Meer, K 2012, 'Quality of life of elderly ischaemic stroke patients one year after thrombolytic therapy. A comparison between patients with and without thrombolytic therapy', BMC NEUROLOGY, vol. 12, 61. https://doi.org/10.1186/1471-2377-12-61

Standard

Quality of life of elderly ischaemic stroke patients one year after thrombolytic therapy. A comparison between patients with and without thrombolytic therapy. / de Weerd, Leonie; Luijckx, Gert-Jan R.; Groenier, Klaas H.; van der Meer, Klaas.

In: BMC NEUROLOGY, Vol. 12, 61, 26.07.2012.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

de Weerd L, Luijckx G-JR, Groenier KH, van der Meer K. Quality of life of elderly ischaemic stroke patients one year after thrombolytic therapy. A comparison between patients with and without thrombolytic therapy. BMC NEUROLOGY. 2012 Jul 26;12. 61. https://doi.org/10.1186/1471-2377-12-61


BibTeX

@article{b8903953cdc44d01b1910c74353c1188,
title = "Quality of life of elderly ischaemic stroke patients one year after thrombolytic therapy. A comparison between patients with and without thrombolytic therapy",
abstract = "Background: An observational study to examine whether thrombolytic therapy in stroke patients realizes better quality of life outcomes compared to patients without thrombolytic therapy one year after stroke. We also examined whether daily functioning, mental functioning and activities improved after thrombolytic treatment.Methods: A total of 88 stroke patients were interviewed at home one year post-stroke. Health-related quality of life (HRQOL) was assessed using the RAND-36, disability with the Barthel Index, depression and anxiety with the Hospital Anxiety and Depression Scale, and a questionnaire about patient way of life was completed. People aged under 60, moving to a nursing home or with a haemorrhage were excluded.Results: The thrombolysis group (TG) had more severe stroke (higher NIHSS) scores and were younger than the group without thrombolytic therapy (WTG). The primary outcome was HRQOL, which was high and nearly identical in both groups, however the TG had significantly better HRQOL for the ;mental 'mental and 'vitality' scales. Patients who stopped or reduced their hobbies because of stroke had a significantly worse HRQOL. One year after stroke, more patients in the TG were totally or severely ADL dependent (12{\%} TG and 0{\%} WTG, p = 0.022). The level of dependence decreased in the TG (p = 0.042) and worsened in the WTG (p <0.001) after one year. Being more dependent is related to diminishing daily occupations in both groups. In the TG the level of dependence had less impact on visiting family and friends and going on holiday. The prevalence of anxiety disorder and depression was low compared to other studies and there is no significant difference between the two groups.Conclusion: No major differences in the primary outcome (HRQOL) could be found between the two groups. In addition, no essential difference could be found in mental functioning and participation. We expected that patients undergoing thrombolytic therapy would have worse quality of life because of the greater initial severity of their stroke. Therefore, thrombolytic therapy seems to be of great importance in achieving better quality of life in ischemic stroke patients who respond to this therapy.",
keywords = "TISSUE-PLASMINOGEN ACTIVATOR, DEPRESSION SCALE, HOSPITAL ANXIETY, RISK-FACTORS, SURVIVORS, OUTCOMES, REHABILITATION, CARE, EPIDEMIOLOGY, DETERMINANTS",
author = "{de Weerd}, Leonie and Luijckx, {Gert-Jan R.} and Groenier, {Klaas H.} and {van der Meer}, Klaas",
year = "2012",
month = "7",
day = "26",
doi = "10.1186/1471-2377-12-61",
language = "English",
volume = "12",
journal = "BMC NEUROLOGY",
issn = "1471-2377",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Quality of life of elderly ischaemic stroke patients one year after thrombolytic therapy. A comparison between patients with and without thrombolytic therapy

AU - de Weerd, Leonie

AU - Luijckx, Gert-Jan R.

AU - Groenier, Klaas H.

AU - van der Meer, Klaas

PY - 2012/7/26

Y1 - 2012/7/26

N2 - Background: An observational study to examine whether thrombolytic therapy in stroke patients realizes better quality of life outcomes compared to patients without thrombolytic therapy one year after stroke. We also examined whether daily functioning, mental functioning and activities improved after thrombolytic treatment.Methods: A total of 88 stroke patients were interviewed at home one year post-stroke. Health-related quality of life (HRQOL) was assessed using the RAND-36, disability with the Barthel Index, depression and anxiety with the Hospital Anxiety and Depression Scale, and a questionnaire about patient way of life was completed. People aged under 60, moving to a nursing home or with a haemorrhage were excluded.Results: The thrombolysis group (TG) had more severe stroke (higher NIHSS) scores and were younger than the group without thrombolytic therapy (WTG). The primary outcome was HRQOL, which was high and nearly identical in both groups, however the TG had significantly better HRQOL for the ;mental 'mental and 'vitality' scales. Patients who stopped or reduced their hobbies because of stroke had a significantly worse HRQOL. One year after stroke, more patients in the TG were totally or severely ADL dependent (12% TG and 0% WTG, p = 0.022). The level of dependence decreased in the TG (p = 0.042) and worsened in the WTG (p <0.001) after one year. Being more dependent is related to diminishing daily occupations in both groups. In the TG the level of dependence had less impact on visiting family and friends and going on holiday. The prevalence of anxiety disorder and depression was low compared to other studies and there is no significant difference between the two groups.Conclusion: No major differences in the primary outcome (HRQOL) could be found between the two groups. In addition, no essential difference could be found in mental functioning and participation. We expected that patients undergoing thrombolytic therapy would have worse quality of life because of the greater initial severity of their stroke. Therefore, thrombolytic therapy seems to be of great importance in achieving better quality of life in ischemic stroke patients who respond to this therapy.

AB - Background: An observational study to examine whether thrombolytic therapy in stroke patients realizes better quality of life outcomes compared to patients without thrombolytic therapy one year after stroke. We also examined whether daily functioning, mental functioning and activities improved after thrombolytic treatment.Methods: A total of 88 stroke patients were interviewed at home one year post-stroke. Health-related quality of life (HRQOL) was assessed using the RAND-36, disability with the Barthel Index, depression and anxiety with the Hospital Anxiety and Depression Scale, and a questionnaire about patient way of life was completed. People aged under 60, moving to a nursing home or with a haemorrhage were excluded.Results: The thrombolysis group (TG) had more severe stroke (higher NIHSS) scores and were younger than the group without thrombolytic therapy (WTG). The primary outcome was HRQOL, which was high and nearly identical in both groups, however the TG had significantly better HRQOL for the ;mental 'mental and 'vitality' scales. Patients who stopped or reduced their hobbies because of stroke had a significantly worse HRQOL. One year after stroke, more patients in the TG were totally or severely ADL dependent (12% TG and 0% WTG, p = 0.022). The level of dependence decreased in the TG (p = 0.042) and worsened in the WTG (p <0.001) after one year. Being more dependent is related to diminishing daily occupations in both groups. In the TG the level of dependence had less impact on visiting family and friends and going on holiday. The prevalence of anxiety disorder and depression was low compared to other studies and there is no significant difference between the two groups.Conclusion: No major differences in the primary outcome (HRQOL) could be found between the two groups. In addition, no essential difference could be found in mental functioning and participation. We expected that patients undergoing thrombolytic therapy would have worse quality of life because of the greater initial severity of their stroke. Therefore, thrombolytic therapy seems to be of great importance in achieving better quality of life in ischemic stroke patients who respond to this therapy.

KW - TISSUE-PLASMINOGEN ACTIVATOR

KW - DEPRESSION SCALE

KW - HOSPITAL ANXIETY

KW - RISK-FACTORS

KW - SURVIVORS

KW - OUTCOMES

KW - REHABILITATION

KW - CARE

KW - EPIDEMIOLOGY

KW - DETERMINANTS

U2 - 10.1186/1471-2377-12-61

DO - 10.1186/1471-2377-12-61

M3 - Article

C2 - 22835054

VL - 12

JO - BMC NEUROLOGY

JF - BMC NEUROLOGY

SN - 1471-2377

M1 - 61

ER -

ID: 5672336