Publication

Pulmonary function and CT biomarkers as risk factors for cardiovascular events in male lung cancer screening participants: the NELSON study

Takx, R. A. P., Vliegenthart, R., Hoesein, F. A. A. M., Isgum, I., de Koning, H. J., Mali, W. P. T. M., van der Aalst, C. M., Zanen, P., Lammers, J-W. J., Groen, H. J. M., van Rikxoort, E. M., Schmidt, M., van Ginneken, B., Oudkerk, M., Leiner, T. & de Jong, P. A., Jan-2015, In : European Radiology. 25, 1, p. 65-71 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Richard A. P. Takx
  • Rozemarijn Vliegenthart
  • Firdaus A. A. Mohamed Hoesein
  • Ivana Isgum
  • Harry J. de Koning
  • Willem P. Th. M. Mali
  • Carlijn M. van der Aalst
  • Pieter Zanen
  • Jan-Willem J. Lammers
  • Harry J. M. Groen
  • Eva M. van Rikxoort
  • Michael Schmidt
  • Bram van Ginneken
  • Matthijs Oudkerk
  • Tim Leiner
  • Pim A. de Jong

Objective The objective of this study was to investigate the association of spirometry and pulmonary CT biomarkers with cardiovascular events.

Methods In this lung cancer screening trial 3,080 male participants without a prior cardiovascular event were analysed. Fatal and non-fatal cardiovascular events were included. Spirometry included forced expiratory volume measured in units of one-second percent predicted (FEV1% predicted) and FEV1 divided by forced vital capacity (FVC; FEV1/FVC). CT examinations were quantified for coronary artery calcium volume, pulmonary emphysema (perc15) and bronchial wall thickness (pi10). Data were analysed via a Cox proportional hazard analysis, net reclassification improvement (NRI) and C-indices.

Results 184 participants experienced a cardiovascular event during a median follow-up of 2.9 years. Age, pack-years and smoking status adjusted hazard ratios were 0.992 (95 % confidence interval (CI) 0.985-0.999) for FEV1% predicted, 1.000 (95% CI 0.986-1.015) for FEV1/FVC, 1.014 (95% CI 1.005-1.023) for perc15 per 10 HU, and 1.269 (95% CI 1.024-1.573) for pi10 per 1 mm. The incremental C-index (

Conclusions Pulmonary CT biomarkers and spirometry measurements were significantly associated with cardiovascular events, but did not contain clinically relevant independent prognostic information for cardiovascular events.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalEuropean Radiology
Volume25
Issue number1
Publication statusPublished - Jan-2015

    Keywords

  • Cardiovascular diseases, Spirometry, Multi-detector computed tomography, Smoking, Mass screening, CORONARY-ARTERY CALCIUM, COMPUTED-TOMOGRAPHY SCANS, HEART-DISEASE, SYSTEMIC INFLAMMATION, FUNCTION IMPAIRMENT, MORTALITY, EMPHYSEMA, PREDICTION, SMOKING, DECLINE
Related Datasets
  1. Nederlands-Leuvens Longkanker Screenings Onderzoek (NELSON)

    Oudkerk, M. (Creator), Groen, H. (Creator), Van Klaveren, R. J. (Creator), de Koning, H. J. (Creator), Mali, W. P. T. M. (Creator), Lammers, J. J. (Creator), University of Groningen, 2018

    Dataset

View all (1) »

View graph of relations

ID: 19494037