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Novel visualization techniques towards identification of atherosclerotic patients at risk

Jager, N., 2014, [S.l.]: [S.n.]. 161 p.

Research output: ThesisThesis fully internal (DIV)Academic

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  • Nynke Jager
Atherosclerosis is an inflammatory disease of the artery wall. The genesis of atherosclerosis is associated with auto-immune diseases (the immune system turns against constituents of the own body) such as rheumatoid arthritis (RA). Atherosclerosis is a chronic process that leads to the formation of atherosclerotic plaques, making the bloodvessels thinning. In part I is several markers for early atherosclerosis have been examined. Examples of this are the endothelial precursor cells (EPCs), vascular endothelial growth factors (VEGF), soluble vascular cell adhesion molecul-1 (sVCAM-1), trombomoduline (TM or CD141) and von Willebrand Factor (vWF), measured in the blood. The vascular elasticity can also be measured (small arterial elasticity; SAE) and the advanced glycation end products (AGEs; measured by the skin with fluorescence (skin AF)). These are related to disease activity in patients with RA, and therefore can be used as risk estimation of cardiovascular disease. As plaques become vulnerable and rupture, which is directly related to cardiovascular diseases, such as a heart attack or stroke. A character of a vulnerable plaque is inflammation. Possible macrophages (a inflammatory cell) can be used to identify inflammatory responses in atherosclerosis, to predict the risk of cardiovascular disease. In part 2, this is done using folate receptor-beta, which is on the surface of activated macrophages, by means of an optical fluorescent contrast agent (FITC) and technetium. Also, matrix metalloproteinases (MMPs; proteins that break down the matrix) have been made visible.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
Award date10-Dec-2014
Place of Publication[S.l.]
Publisher
Print ISBNs978-90-367-7398-0
Electronic ISBNs978-90-367-7397-3
Publication statusPublished - 2014

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