Psychosocial factors associated with indices of cortisol production in women with breast cancer and controls

Vedhara, K., Tuinstra, J., Miles, J. N. V., Sanderman, R. & Ranchor, A. V., Apr-2006, In : Psychoneuroendocrinology. 31, 3, p. 299-311 13 p.

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The present study was designed to (i) explore which psychosocial factors were associated with indices representing the early morning peak, diurnal cortisol rhythm and area under the curve (AUC); (ii) examine whether the relationships between psychosocial functioning and these cortisol indices were consistent and (iii) explore whether these relationships were influenced by the clinical status of the participant. Newly diagnosed breast cancer patients (n = 85) and healthy control women (n=59) were recruited. State and trait measures of psychosocial functioning (i.e. anxiety, depression, distress, neuroticism, extraversion, marital satisfaction and mastery) were undertaken. In addition, all participants provided four saliva samples (on waking, 30 min later, between 11 and 1 p.m., before lunch and between 8 and 10 p.m., at Least 2 h after evening meal) over two consecutive days to assess cortisol levels. The results highlighted the divergent nature of the four cortisol indices; revealed the presence of some significant relationships between the psychosocial. measures and the cortisol. indices; but highlighted inconsistencies in the relationships evident for patients and those observed for control women. (C) 2005 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)299-311
Number of pages13
Issue number3
Publication statusPublished - Apr-2006


  • cortisol, distress, neuroticism, area under the curve (AUC), early morning peak, diurnal rhythm, breast cancer, SALIVARY CORTISOL, INDIVIDUAL-DIFFERENCES, HEALTHY-VOLUNTEERS, DEPRESSION SCALE, HOSPITAL ANXIETY, STRESS, PERSONALITY, TEMPERAMENT, REACTIVITY, SECRETION

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