Publication

Proton pump inhibitors when using clopidogrel: balance between necessity and disadvantages

van der Elst, K., Oortgiesen, B., Kruik-Kollöffel, W., Hoogendoorn, M., Hofma, S. & van Roon, E., 24-May-2019, In : Nederlands Tijdschrift voor Geneeskunde. 163, 24

Research output: Contribution to journalArticleProfessional

APA

van der Elst, K., Oortgiesen, B., Kruik-Kollöffel, W., Hoogendoorn, M., Hofma, S., & van Roon, E. (2019). Proton pump inhibitors when using clopidogrel: balance between necessity and disadvantages. Nederlands Tijdschrift voor Geneeskunde, 163(24).

Author

van der Elst, Kim ; Oortgiesen, Berdien ; Kruik-Kollöffel, Willemien ; Hoogendoorn, Mels ; Hofma, Sjoerd ; van Roon, Eric. / Proton pump inhibitors when using clopidogrel : balance between necessity and disadvantages. In: Nederlands Tijdschrift voor Geneeskunde. 2019 ; Vol. 163, No. 24.

Harvard

van der Elst, K, Oortgiesen, B, Kruik-Kollöffel, W, Hoogendoorn, M, Hofma, S & van Roon, E 2019, 'Proton pump inhibitors when using clopidogrel: balance between necessity and disadvantages' Nederlands Tijdschrift voor Geneeskunde, vol. 163, no. 24.

Standard

Proton pump inhibitors when using clopidogrel : balance between necessity and disadvantages. / van der Elst, Kim; Oortgiesen, Berdien; Kruik-Kollöffel, Willemien; Hoogendoorn, Mels; Hofma, Sjoerd; van Roon, Eric.

In: Nederlands Tijdschrift voor Geneeskunde, Vol. 163, No. 24, 24.05.2019.

Research output: Contribution to journalArticleProfessional

Vancouver

van der Elst K, Oortgiesen B, Kruik-Kollöffel W, Hoogendoorn M, Hofma S, van Roon E. Proton pump inhibitors when using clopidogrel: balance between necessity and disadvantages. Nederlands Tijdschrift voor Geneeskunde. 2019 May 24;163(24).


BibTeX

@article{98add55e5ad7470e86c49f0cfcdef6e3,
title = "Proton pump inhibitors when using clopidogrel: balance between necessity and disadvantages",
abstract = "Rationale When patients are using carbasalate calcium or acetylsalicylic acid (ASA), it is recommended to prescribe a proton pump inhibitor (PPI) in order to prevent gastrointestinal (GI) bleeding. Should this recommendation also be followed for patients who are using clopidogrel in monotherapy, which is increasingly the case in practice? Method In a systematic literature review of the occurrence of GI bleeding when using clopidogrel versus ASA, we included 9 studies that compared the risk of GI bleeding when using ASA with clopidogrel monotherapy. Results These 9 studies on clopidogrel and ASA show that the risk of GI bleeding is also elevated when using clopidogrel monotherapy and that it is comparable with the risk of GI bleeding when using ASA. Conclusion Based on the current literature, we recommend prescribing pantoprazole to patients who are using clopidogrel monotherapy and have additional risk factors for GI bleeding, in accordance with the procedure for low-dose ASA. The risk of GI bleeding must be weighed against the disadvantages of using PPIs.",
keywords = "adult, adverse drug reaction, article, clinical trial (topic), controlled study, drug therapy, female, gastrointestinal hemorrhage, human, low drug dose, male, monotherapy, prescription, risk factor, side effect, systematic review, acetylsalicylic acid, clopidogrel, pantoprazole",
author = "{van der Elst}, Kim and Berdien Oortgiesen and Willemien Kruik-Koll{\"o}ffel and Mels Hoogendoorn and Sjoerd Hofma and {van Roon}, Eric",
year = "2019",
month = "5",
day = "24",
language = "English",
volume = "163",
journal = "Ned Tijdschr Geneeskd",
issn = "0028-2162",
publisher = "NLM (Medline)",
number = "24",

}

RIS

TY - JOUR

T1 - Proton pump inhibitors when using clopidogrel

T2 - balance between necessity and disadvantages

AU - van der Elst, Kim

AU - Oortgiesen, Berdien

AU - Kruik-Kollöffel, Willemien

AU - Hoogendoorn, Mels

AU - Hofma, Sjoerd

AU - van Roon, Eric

PY - 2019/5/24

Y1 - 2019/5/24

N2 - Rationale When patients are using carbasalate calcium or acetylsalicylic acid (ASA), it is recommended to prescribe a proton pump inhibitor (PPI) in order to prevent gastrointestinal (GI) bleeding. Should this recommendation also be followed for patients who are using clopidogrel in monotherapy, which is increasingly the case in practice? Method In a systematic literature review of the occurrence of GI bleeding when using clopidogrel versus ASA, we included 9 studies that compared the risk of GI bleeding when using ASA with clopidogrel monotherapy. Results These 9 studies on clopidogrel and ASA show that the risk of GI bleeding is also elevated when using clopidogrel monotherapy and that it is comparable with the risk of GI bleeding when using ASA. Conclusion Based on the current literature, we recommend prescribing pantoprazole to patients who are using clopidogrel monotherapy and have additional risk factors for GI bleeding, in accordance with the procedure for low-dose ASA. The risk of GI bleeding must be weighed against the disadvantages of using PPIs.

AB - Rationale When patients are using carbasalate calcium or acetylsalicylic acid (ASA), it is recommended to prescribe a proton pump inhibitor (PPI) in order to prevent gastrointestinal (GI) bleeding. Should this recommendation also be followed for patients who are using clopidogrel in monotherapy, which is increasingly the case in practice? Method In a systematic literature review of the occurrence of GI bleeding when using clopidogrel versus ASA, we included 9 studies that compared the risk of GI bleeding when using ASA with clopidogrel monotherapy. Results These 9 studies on clopidogrel and ASA show that the risk of GI bleeding is also elevated when using clopidogrel monotherapy and that it is comparable with the risk of GI bleeding when using ASA. Conclusion Based on the current literature, we recommend prescribing pantoprazole to patients who are using clopidogrel monotherapy and have additional risk factors for GI bleeding, in accordance with the procedure for low-dose ASA. The risk of GI bleeding must be weighed against the disadvantages of using PPIs.

KW - adult

KW - adverse drug reaction

KW - article

KW - clinical trial (topic)

KW - controlled study

KW - drug therapy

KW - female

KW - gastrointestinal hemorrhage

KW - human

KW - low drug dose

KW - male

KW - monotherapy

KW - prescription

KW - risk factor

KW - side effect

KW - systematic review

KW - acetylsalicylic acid

KW - clopidogrel

KW - pantoprazole

M3 - Article

VL - 163

JO - Ned Tijdschr Geneeskd

JF - Ned Tijdschr Geneeskd

SN - 0028-2162

IS - 24

ER -

ID: 87539388