Publication

Protein conducting channels-mechanisms, structures and applications

Bonardi, F., Nouwen, N., Feringa, B. L. & Driessen, A. J. M., 2012, In : Molecular BioSystems. 8, 3, p. 709-719 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Bonardi, F., Nouwen, N., Feringa, B. L., & Driessen, A. J. M. (2012). Protein conducting channels-mechanisms, structures and applications. Molecular BioSystems, 8(3), 709-719. https://doi.org/10.1039/c2mb05433g

Author

Bonardi, Francesco ; Nouwen, Nico ; Feringa, Ben L. ; Driessen, Arnold J.M. / Protein conducting channels-mechanisms, structures and applications. In: Molecular BioSystems. 2012 ; Vol. 8, No. 3. pp. 709-719.

Harvard

Bonardi, F, Nouwen, N, Feringa, BL & Driessen, AJM 2012, 'Protein conducting channels-mechanisms, structures and applications', Molecular BioSystems, vol. 8, no. 3, pp. 709-719. https://doi.org/10.1039/c2mb05433g

Standard

Protein conducting channels-mechanisms, structures and applications. / Bonardi, Francesco; Nouwen, Nico; Feringa, Ben L.; Driessen, Arnold J.M.

In: Molecular BioSystems, Vol. 8, No. 3, 2012, p. 709-719.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Bonardi F, Nouwen N, Feringa BL, Driessen AJM. Protein conducting channels-mechanisms, structures and applications. Molecular BioSystems. 2012;8(3):709-719. https://doi.org/10.1039/c2mb05433g


BibTeX

@article{7cabea337d114fb39dfe3e6d67e56fd7,
title = "Protein conducting channels-mechanisms, structures and applications",
abstract = "In the past decade among the main developments in the field of bionanotechnology is the application of proteins in devices. Research focuses on the modification of enzyme systems by means of chemical and physical tools in order to achieve full control of their function and to employ them for specific tasks. Membrane protein channels are intriguing biological devices as they allow the recognition and passage of a variety of macromolecules through an otherwise impermeable lipid bilayer. Hence, membrane proteins can be used as sensory devices for detection or as molecular nanovalves to allow for the controlled release of molecules. Here, we discuss the structure and function of three different channel proteins that mediate the membrane passage of macromolecules using different mechanisms. These systems are described in a comparative manner and an overview is provided of the technological advances in employing these proteins in external (or human) controllable devices.",
keywords = "STAPHYLOCOCCAL ALPHA-TOXIN, MECHANOSENSITIVE ION CHANNELS, SECYEG TRANSLOCATION CHANNEL, SIGNAL RECOGNITION PARTICLE, ESCHERICHIA-COLI-CELLS, PORE-FORMING TOXINS, PREPROTEIN TRANSLOCATION, CROSS-LINKING, CONFORMATIONAL-CHANGES, GATING MECHANISM",
author = "Francesco Bonardi and Nico Nouwen and Feringa, {Ben L.} and Driessen, {Arnold J.M.}",
note = "Relation: https://www.rug.nl/fmns-research/gbb/index Rights: University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute (GBB)",
year = "2012",
doi = "10.1039/c2mb05433g",
language = "English",
volume = "8",
pages = "709--719",
journal = "Molecular BioSystems",
issn = "1742-206X",
publisher = "ROYAL SOC CHEMISTRY",
number = "3",

}

RIS

TY - JOUR

T1 - Protein conducting channels-mechanisms, structures and applications

AU - Bonardi, Francesco

AU - Nouwen, Nico

AU - Feringa, Ben L.

AU - Driessen, Arnold J.M.

N1 - Relation: https://www.rug.nl/fmns-research/gbb/index Rights: University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute (GBB)

PY - 2012

Y1 - 2012

N2 - In the past decade among the main developments in the field of bionanotechnology is the application of proteins in devices. Research focuses on the modification of enzyme systems by means of chemical and physical tools in order to achieve full control of their function and to employ them for specific tasks. Membrane protein channels are intriguing biological devices as they allow the recognition and passage of a variety of macromolecules through an otherwise impermeable lipid bilayer. Hence, membrane proteins can be used as sensory devices for detection or as molecular nanovalves to allow for the controlled release of molecules. Here, we discuss the structure and function of three different channel proteins that mediate the membrane passage of macromolecules using different mechanisms. These systems are described in a comparative manner and an overview is provided of the technological advances in employing these proteins in external (or human) controllable devices.

AB - In the past decade among the main developments in the field of bionanotechnology is the application of proteins in devices. Research focuses on the modification of enzyme systems by means of chemical and physical tools in order to achieve full control of their function and to employ them for specific tasks. Membrane protein channels are intriguing biological devices as they allow the recognition and passage of a variety of macromolecules through an otherwise impermeable lipid bilayer. Hence, membrane proteins can be used as sensory devices for detection or as molecular nanovalves to allow for the controlled release of molecules. Here, we discuss the structure and function of three different channel proteins that mediate the membrane passage of macromolecules using different mechanisms. These systems are described in a comparative manner and an overview is provided of the technological advances in employing these proteins in external (or human) controllable devices.

KW - STAPHYLOCOCCAL ALPHA-TOXIN

KW - MECHANOSENSITIVE ION CHANNELS

KW - SECYEG TRANSLOCATION CHANNEL

KW - SIGNAL RECOGNITION PARTICLE

KW - ESCHERICHIA-COLI-CELLS

KW - PORE-FORMING TOXINS

KW - PREPROTEIN TRANSLOCATION

KW - CROSS-LINKING

KW - CONFORMATIONAL-CHANGES

KW - GATING MECHANISM

U2 - 10.1039/c2mb05433g

DO - 10.1039/c2mb05433g

M3 - Article

VL - 8

SP - 709

EP - 719

JO - Molecular BioSystems

JF - Molecular BioSystems

SN - 1742-206X

IS - 3

ER -

ID: 2306837