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Protein conducting channels-mechanisms, structures and applications

Bonardi, F., Nouwen, N., Feringa, B. L. & Driessen, A. J. M., 2012, In : Molecular BioSystems. 8, 3, p. 709-719 11 p.

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DOI

In the past decade among the main developments in the field of bionanotechnology is the application of proteins in devices. Research focuses on the modification of enzyme systems by means of chemical and physical tools in order to achieve full control of their function and to employ them for specific tasks. Membrane protein channels are intriguing biological devices as they allow the recognition and passage of a variety of macromolecules through an otherwise impermeable lipid bilayer. Hence, membrane proteins can be used as sensory devices for detection or as molecular nanovalves to allow for the controlled release of molecules. Here, we discuss the structure and function of three different channel proteins that mediate the membrane passage of macromolecules using different mechanisms. These systems are described in a comparative manner and an overview is provided of the technological advances in employing these proteins in external (or human) controllable devices.

Original languageEnglish
Pages (from-to)709-719
Number of pages11
JournalMolecular BioSystems
Volume8
Issue number3
Publication statusPublished - 2012

    Keywords

  • STAPHYLOCOCCAL ALPHA-TOXIN, MECHANOSENSITIVE ION CHANNELS, SECYEG TRANSLOCATION CHANNEL, SIGNAL RECOGNITION PARTICLE, ESCHERICHIA-COLI-CELLS, PORE-FORMING TOXINS, PREPROTEIN TRANSLOCATION, CROSS-LINKING, CONFORMATIONAL-CHANGES, GATING MECHANISM

ID: 2306837