Publication

Protective role of endothelial nitric oxide synthase

Albrecht, E. W. J. A., Stegeman, C. A., Heeringa, P., Henning, R. & van Goor, H., Jan-2003, In : JOURNAL OF PATHOLOGY. 199, 1, p. 8-17 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Nitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to anti-proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the nitric oxide synthases, endothelial NOS (eNOS), neural NOS (nNOS), and inducible NOS (iNOS). Constitutively expressed eNOS produces low concentrations of NO, which is necessary for a good endothelial function and integrity. Endothelial derived NO is often seen as a protective agent in a variety of diseases. This review will focus on the potential protective role of eNOS. We will discuss recent data derived from studies in eNOS knockout mice and other experimental models. Furthermore, the role of eNOS in human diseases is described and possible therapeutic intervention strategies will be discussed.

Original languageEnglish
Pages (from-to)8-17
Number of pages10
JournalJOURNAL OF PATHOLOGY
Volume199
Issue number1
Publication statusPublished - Jan-2003

    Keywords

  • nitric oxide, endothelial nitric oxide synthase, endothelium, endothelial dysfunction, vascular tone, knockout mice, pharmacological inhibition, CORONARY-ARTERY DISEASE, ISCHEMIA-REPERFUSION INJURY, L-ARGININE SUPPLEMENTATION, VASCULAR SMOOTH-MUSCLE, PEROXYNITRITE-MODIFIED PROTEINS, SALT-SENSITIVE HYPERTENSION, RENAL OXYGEN-CONSUMPTION, INDUCED UP-REGULATION, GENE-EXPRESSION, KNOCKOUT MICE

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