Publication

Proportion of Patients Treated With Thrombolysis in a Centralized Versus a Decentralized Acute Stroke Care Setting

Lahr, M. M. H., Luijckx, G. J., Vroomen, P. C. A. J., van der Zee, D. J. & Buskens, E., May-2012, In : Stroke. 43, 5, p. 1336-1340 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Lahr_2012_Stroke.pdf

    Final publisher's version, 692 KB, PDF document

DOI

Background and Purpose-Today, treatment of acute stroke consists of tissue-type plasminogen activator (tPA), admission to a stroke unit, and aspirin. Although tPA treatment is the most effective, there is substantial undertreatment. Centralized care may affect rate, timing, and outcome of thrombolysis compared to decentralized treatment in community hospitals. The present study aimed to assess the impact of organizational models on the proportion of patients undergoing tPA treatment.

Methods-A prospective, multicenter, observational study among 13 hospitals in the North of the Netherlands was conducted. In the centralized model, tPA treatment for 4 hospitals was administered in 1 stroke center. The decentralized model comprised 9 community hospitals. Primary outcome was the proportion of patients treated with tPA. Secondary outcome measures were proportion of patients arriving within 4.5 hours, safety, 90-day functional outcome, and onset-to-door, door-to-needle, and onset-to-needle times. Potential confounders were adjusted using logistic regression analysis.

Results-Two hundred eighty-three and 801 ischemic stroke patients were enrolled in the centralized and decentralized settings. Numbers of patients treated with tPA were 62 (21.9%) and 113 (14.1%) (OR, 1.72; 95% CI, 1.22-2.43). Adjusting for potential confounders did not alter results (OR, 2.03; 95% CI, 1.39-2.96). In the centralized setting, significantly more patients arrived at the hospital within the 4.5-hour time window (P <0.01), and shorter door-to-needle times were reached (35 versus 47 minutes). Other secondary outcome measures did not differ across setting.

Conclusions-In a centralized setting, the results demonstrate a 50% increased likelihood of treatment. Prehospital factors seem to contribute to this result. (Stroke. 2012;43:1336-1340.)

Original languageEnglish
Pages (from-to)1336-1340
Number of pages5
JournalStroke
Volume43
Issue number5
Publication statusPublished - May-2012

    Keywords

  • acute stroke, implementation, organizational model, thrombolysis, ACUTE ISCHEMIC-STROKE, TISSUE-PLASMINOGEN ACTIVATOR, EXPERIENCE, ALTEPLASE, CENTERS, OLDER

ID: 2106447