Publication

Programming effects of an early-life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet

Ronda, O. A. H. O., van de Heijning, B. J. M., de Bruin, A., Jurdzinski, A., Kuipers, F. & Verkade, H. J., 28-Dec-2019, In : British Journal of Nutrition. 122, 12, p. 1321-1328 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Ronda, O. A. H. O., van de Heijning, B. J. M., de Bruin, A., Jurdzinski, A., Kuipers, F., & Verkade, H. J. (2019). Programming effects of an early-life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet. British Journal of Nutrition, 122(12), 1321-1328. https://doi.org/10.1017/S0007114519002083

Author

Ronda, Onne A H O ; van de Heijning, Bert J M ; de Bruin, Alain ; Jurdzinski, Angelika ; Kuipers, Folkert ; Verkade, Henkjan J. / Programming effects of an early-life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet. In: British Journal of Nutrition. 2019 ; Vol. 122, No. 12. pp. 1321-1328.

Harvard

Ronda, OAHO, van de Heijning, BJM, de Bruin, A, Jurdzinski, A, Kuipers, F & Verkade, HJ 2019, 'Programming effects of an early-life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet', British Journal of Nutrition, vol. 122, no. 12, pp. 1321-1328. https://doi.org/10.1017/S0007114519002083

Standard

Programming effects of an early-life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet. / Ronda, Onne A H O; van de Heijning, Bert J M; de Bruin, Alain; Jurdzinski, Angelika; Kuipers, Folkert; Verkade, Henkjan J.

In: British Journal of Nutrition, Vol. 122, No. 12, 28.12.2019, p. 1321-1328.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Ronda OAHO, van de Heijning BJM, de Bruin A, Jurdzinski A, Kuipers F, Verkade HJ. Programming effects of an early-life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet. British Journal of Nutrition. 2019 Dec 28;122(12):1321-1328. https://doi.org/10.1017/S0007114519002083


BibTeX

@article{f788777be2bf4687bd011f062498926c,
title = "Programming effects of an early-life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet",
abstract = "Breastfeeding is associated with a lower risk of developing obesity during childhood and adulthood compared to feeding infant milk formula (IMF). Previous studies have shown that an experimental IMF (eIMF; comprising Nuturis{\circledR}), programmed mouse pups for a lower body weight and fat mass gain in adulthood when challenged with a high-fat diet (HFD), compared to a control IMF (cIMF). Nuturis has a lipid composition and structure more similar to breastmilk. Here, the long-term effects were tested of a similar eIMF, but with an adapted lipid composition, and a cIMF, on body weight, glucose homeostasis, liver and adipose tissue. Nutrient composition was similar for the eIMF and cIMF; the lipid fractions comprised ~50{\%} milkfat. C57BL/6JOlaHsd mice were fed cIMF or eIMF from postnatal (PN) day 16-42 followed by a HFD until PN168. Feeding eIMF versus cIMF in early life resulted in a lower body weight (-9{\%}) and body fat deposition (-14{\%}) in adulthood (PN105). The effect appeared transient, as from PN126 onward, after 12 weeks HFD, eIMF-fed mice caught up on controls and body and fat weights became comparable between groups. Glucose and energy metabolism were similar between groups. At dissection (PN168), eIMF-fed mice showed larger (+27{\%}) epididymal fat depots and a lower (-26{\%}) liver weight without clear morphological aberrations. Our data suggest the size and coating but not the lipid composition of IMF fat globules underlies the programming effect observed. Prolonged exposure to a HFD challenge partly overrules the programming effect of early diet.",
keywords = "Metabolic programming, Infant nutrition, Dietary lipids, Lipid structure, Milk fat globule membrane, Obesity prevention, Animal models, BREAST-MILK, SIZE, ABSORPTION, FORMULA, TISSUE, ACID, ACCUMULATION, CHOLESTEROL, LIPOLYSIS, DROPLETS",
author = "Ronda, {Onne A H O} and {van de Heijning}, {Bert J M} and {de Bruin}, Alain and Angelika Jurdzinski and Folkert Kuipers and Verkade, {Henkjan J}",
year = "2019",
month = "12",
day = "28",
doi = "10.1017/S0007114519002083",
language = "English",
volume = "122",
pages = "1321--1328",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "12",

}

RIS

TY - JOUR

T1 - Programming effects of an early-life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet

AU - Ronda, Onne A H O

AU - van de Heijning, Bert J M

AU - de Bruin, Alain

AU - Jurdzinski, Angelika

AU - Kuipers, Folkert

AU - Verkade, Henkjan J

PY - 2019/12/28

Y1 - 2019/12/28

N2 - Breastfeeding is associated with a lower risk of developing obesity during childhood and adulthood compared to feeding infant milk formula (IMF). Previous studies have shown that an experimental IMF (eIMF; comprising Nuturis®), programmed mouse pups for a lower body weight and fat mass gain in adulthood when challenged with a high-fat diet (HFD), compared to a control IMF (cIMF). Nuturis has a lipid composition and structure more similar to breastmilk. Here, the long-term effects were tested of a similar eIMF, but with an adapted lipid composition, and a cIMF, on body weight, glucose homeostasis, liver and adipose tissue. Nutrient composition was similar for the eIMF and cIMF; the lipid fractions comprised ~50% milkfat. C57BL/6JOlaHsd mice were fed cIMF or eIMF from postnatal (PN) day 16-42 followed by a HFD until PN168. Feeding eIMF versus cIMF in early life resulted in a lower body weight (-9%) and body fat deposition (-14%) in adulthood (PN105). The effect appeared transient, as from PN126 onward, after 12 weeks HFD, eIMF-fed mice caught up on controls and body and fat weights became comparable between groups. Glucose and energy metabolism were similar between groups. At dissection (PN168), eIMF-fed mice showed larger (+27%) epididymal fat depots and a lower (-26%) liver weight without clear morphological aberrations. Our data suggest the size and coating but not the lipid composition of IMF fat globules underlies the programming effect observed. Prolonged exposure to a HFD challenge partly overrules the programming effect of early diet.

AB - Breastfeeding is associated with a lower risk of developing obesity during childhood and adulthood compared to feeding infant milk formula (IMF). Previous studies have shown that an experimental IMF (eIMF; comprising Nuturis®), programmed mouse pups for a lower body weight and fat mass gain in adulthood when challenged with a high-fat diet (HFD), compared to a control IMF (cIMF). Nuturis has a lipid composition and structure more similar to breastmilk. Here, the long-term effects were tested of a similar eIMF, but with an adapted lipid composition, and a cIMF, on body weight, glucose homeostasis, liver and adipose tissue. Nutrient composition was similar for the eIMF and cIMF; the lipid fractions comprised ~50% milkfat. C57BL/6JOlaHsd mice were fed cIMF or eIMF from postnatal (PN) day 16-42 followed by a HFD until PN168. Feeding eIMF versus cIMF in early life resulted in a lower body weight (-9%) and body fat deposition (-14%) in adulthood (PN105). The effect appeared transient, as from PN126 onward, after 12 weeks HFD, eIMF-fed mice caught up on controls and body and fat weights became comparable between groups. Glucose and energy metabolism were similar between groups. At dissection (PN168), eIMF-fed mice showed larger (+27%) epididymal fat depots and a lower (-26%) liver weight without clear morphological aberrations. Our data suggest the size and coating but not the lipid composition of IMF fat globules underlies the programming effect observed. Prolonged exposure to a HFD challenge partly overrules the programming effect of early diet.

KW - Metabolic programming

KW - Infant nutrition

KW - Dietary lipids

KW - Lipid structure

KW - Milk fat globule membrane

KW - Obesity prevention

KW - Animal models

KW - BREAST-MILK

KW - SIZE

KW - ABSORPTION

KW - FORMULA

KW - TISSUE

KW - ACID

KW - ACCUMULATION

KW - CHOLESTEROL

KW - LIPOLYSIS

KW - DROPLETS

U2 - 10.1017/S0007114519002083

DO - 10.1017/S0007114519002083

M3 - Article

C2 - 31439052

VL - 122

SP - 1321

EP - 1328

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 12

ER -

ID: 94889736