Publication

Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation

Mordi, I. R., Santema, B. T., Kloosterman, M., Choy, A-M., Rienstra, M., van Gelder, I., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., van der Harst, P., Hillege, H. L., Metra, M., Ng, L. L., Ouwerkerk, W., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H., Zannad, F., Voors, A. A. & Lang, C. C., Jul-2019, In : Clinical Research in Cardiology. 108, 7, p. 797-805 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Mordi, I. R., Santema, B. T., Kloosterman, M., Choy, A-M., Rienstra, M., van Gelder, I., ... Lang, C. C. (2019). Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation. Clinical Research in Cardiology, 108(7), 797-805. https://doi.org/10.1007/s00392-018-1409-x

Author

Mordi, Ify R. ; Santema, Bernadet T. ; Kloosterman, Marielle ; Choy, Anna-Maria ; Rienstra, Michiel ; van Gelder, Isabelle ; Anker, Stefan D. ; Cleland, John G. ; Dickstein, Kenneth ; Filippatos, Gerasimos ; van der Harst, Pim ; Hillege, Hans L. ; Metra, Marco ; Ng, Leong L. ; Ouwerkerk, Wouter ; Ponikowski, Piotr ; Samani, Nilesh J. ; van Veldhuisen, Dirk J. ; Zwinderman, Aeilko H. ; Zannad, Faiez ; Voors, Adriaan A. ; Lang, Chim C. / Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation. In: Clinical Research in Cardiology. 2019 ; Vol. 108, No. 7. pp. 797-805.

Harvard

Mordi, IR, Santema, BT, Kloosterman, M, Choy, A-M, Rienstra, M, van Gelder, I, Anker, SD, Cleland, JG, Dickstein, K, Filippatos, G, van der Harst, P, Hillege, HL, Metra, M, Ng, LL, Ouwerkerk, W, Ponikowski, P, Samani, NJ, van Veldhuisen, DJ, Zwinderman, AH, Zannad, F, Voors, AA & Lang, CC 2019, 'Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation', Clinical Research in Cardiology, vol. 108, no. 7, pp. 797-805. https://doi.org/10.1007/s00392-018-1409-x

Standard

Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation. / Mordi, Ify R.; Santema, Bernadet T.; Kloosterman, Marielle; Choy, Anna-Maria; Rienstra, Michiel; van Gelder, Isabelle; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos; van der Harst, Pim; Hillege, Hans L.; Metra, Marco; Ng, Leong L.; Ouwerkerk, Wouter; Ponikowski, Piotr; Samani, Nilesh J.; van Veldhuisen, Dirk J.; Zwinderman, Aeilko H.; Zannad, Faiez; Voors, Adriaan A.; Lang, Chim C.

In: Clinical Research in Cardiology, Vol. 108, No. 7, 07.2019, p. 797-805.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Mordi IR, Santema BT, Kloosterman M, Choy A-M, Rienstra M, van Gelder I et al. Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation. Clinical Research in Cardiology. 2019 Jul;108(7):797-805. https://doi.org/10.1007/s00392-018-1409-x


BibTeX

@article{29daed29bd3141639dcbe86cc4af5d87,
title = "Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation",
abstract = "BackgroundIn patients with heart failure with reduced ejection fraction (HFrEF) on sub-optimal doses of beta-blockers, it is conceivable that changes in heart rate following treatment intensification might be important regardless of underlying heart rhythm. We aimed to compare the prognostic significance of both achieved heart rate and change in heart rate following beta-blocker uptitration in patients with HFrEF either in sinus rhythm (SR) or atrial fibrillation (AF).MethodsWe performed a post hoc analysis of the BIOSTAT-CHF study. We evaluated 1548 patients with HFrEF (mean age 67 years, 35{\%} AF). Median follow-up was 21months. Patients were evaluated at baseline and at 9months. The combined primary outcome was all-cause mortality and heart failure hospitalisation stratified by heart rhythm and heart rate at baseline.ResultsDespite similar changes in heart rate and beta-blocker dose, a decrease in heart rate at 9months was associated with reduced incidence of the primary outcome in both SR and AF patients [HR per 10bpm decreaseSR: 0.83 (0.75-0.91), p",
keywords = "Heart failure, Heart rate, Atrial fibrillation, Beta-blockers, RATE REDUCTION, OUTCOMES, CARVEDILOL, DEATH",
author = "Mordi, {Ify R.} and Santema, {Bernadet T.} and Marielle Kloosterman and Anna-Maria Choy and Michiel Rienstra and {van Gelder}, Isabelle and Anker, {Stefan D.} and Cleland, {John G.} and Kenneth Dickstein and Gerasimos Filippatos and {van der Harst}, Pim and Hillege, {Hans L.} and Marco Metra and Ng, {Leong L.} and Wouter Ouwerkerk and Piotr Ponikowski and Samani, {Nilesh J.} and {van Veldhuisen}, {Dirk J.} and Zwinderman, {Aeilko H.} and Faiez Zannad and Voors, {Adriaan A.} and Lang, {Chim C.}",
year = "2019",
month = "7",
doi = "10.1007/s00392-018-1409-x",
language = "English",
volume = "108",
pages = "797--805",
journal = "Clinical Research in Cardiology",
issn = "1861-0684",
publisher = "SPRINGER HEIDELBERG",
number = "7",

}

RIS

TY - JOUR

T1 - Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation

AU - Mordi, Ify R.

AU - Santema, Bernadet T.

AU - Kloosterman, Marielle

AU - Choy, Anna-Maria

AU - Rienstra, Michiel

AU - van Gelder, Isabelle

AU - Anker, Stefan D.

AU - Cleland, John G.

AU - Dickstein, Kenneth

AU - Filippatos, Gerasimos

AU - van der Harst, Pim

AU - Hillege, Hans L.

AU - Metra, Marco

AU - Ng, Leong L.

AU - Ouwerkerk, Wouter

AU - Ponikowski, Piotr

AU - Samani, Nilesh J.

AU - van Veldhuisen, Dirk J.

AU - Zwinderman, Aeilko H.

AU - Zannad, Faiez

AU - Voors, Adriaan A.

AU - Lang, Chim C.

PY - 2019/7

Y1 - 2019/7

N2 - BackgroundIn patients with heart failure with reduced ejection fraction (HFrEF) on sub-optimal doses of beta-blockers, it is conceivable that changes in heart rate following treatment intensification might be important regardless of underlying heart rhythm. We aimed to compare the prognostic significance of both achieved heart rate and change in heart rate following beta-blocker uptitration in patients with HFrEF either in sinus rhythm (SR) or atrial fibrillation (AF).MethodsWe performed a post hoc analysis of the BIOSTAT-CHF study. We evaluated 1548 patients with HFrEF (mean age 67 years, 35% AF). Median follow-up was 21months. Patients were evaluated at baseline and at 9months. The combined primary outcome was all-cause mortality and heart failure hospitalisation stratified by heart rhythm and heart rate at baseline.ResultsDespite similar changes in heart rate and beta-blocker dose, a decrease in heart rate at 9months was associated with reduced incidence of the primary outcome in both SR and AF patients [HR per 10bpm decreaseSR: 0.83 (0.75-0.91), p

AB - BackgroundIn patients with heart failure with reduced ejection fraction (HFrEF) on sub-optimal doses of beta-blockers, it is conceivable that changes in heart rate following treatment intensification might be important regardless of underlying heart rhythm. We aimed to compare the prognostic significance of both achieved heart rate and change in heart rate following beta-blocker uptitration in patients with HFrEF either in sinus rhythm (SR) or atrial fibrillation (AF).MethodsWe performed a post hoc analysis of the BIOSTAT-CHF study. We evaluated 1548 patients with HFrEF (mean age 67 years, 35% AF). Median follow-up was 21months. Patients were evaluated at baseline and at 9months. The combined primary outcome was all-cause mortality and heart failure hospitalisation stratified by heart rhythm and heart rate at baseline.ResultsDespite similar changes in heart rate and beta-blocker dose, a decrease in heart rate at 9months was associated with reduced incidence of the primary outcome in both SR and AF patients [HR per 10bpm decreaseSR: 0.83 (0.75-0.91), p

KW - Heart failure

KW - Heart rate

KW - Atrial fibrillation

KW - Beta-blockers

KW - RATE REDUCTION

KW - OUTCOMES

KW - CARVEDILOL

KW - DEATH

U2 - 10.1007/s00392-018-1409-x

DO - 10.1007/s00392-018-1409-x

M3 - Article

VL - 108

SP - 797

EP - 805

JO - Clinical Research in Cardiology

JF - Clinical Research in Cardiology

SN - 1861-0684

IS - 7

ER -

ID: 93759283