Publication

Production of Physiologically Relevant Quantities of Hemostatic Proteins During Ex Situ Normothermic Machine Perfusion of Human Livers

Karangwa, S. A., Adelmeijer, J., Matton, A. P. M., de Meijer, V. E., Lisman, T. & Porte, R. J., Sep-2018, In : Liver Transplantation. 24, 9, p. 1298-1302 5 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

APA

Karangwa, S. A., Adelmeijer, J., Matton, A. P. M., de Meijer, V. E., Lisman, T., & Porte, R. J. (2018). Production of Physiologically Relevant Quantities of Hemostatic Proteins During Ex Situ Normothermic Machine Perfusion of Human Livers. Liver Transplantation, 24(9), 1298-1302. https://doi.org/10.1002/lt.25290

Author

Karangwa, Shanice A ; Adelmeijer, Jelle ; Matton, Alix P M ; de Meijer, Vincent E ; Lisman, Ton ; Porte, Robert J. / Production of Physiologically Relevant Quantities of Hemostatic Proteins During Ex Situ Normothermic Machine Perfusion of Human Livers. In: Liver Transplantation. 2018 ; Vol. 24, No. 9. pp. 1298-1302.

Harvard

Karangwa, SA, Adelmeijer, J, Matton, APM, de Meijer, VE, Lisman, T & Porte, RJ 2018, 'Production of Physiologically Relevant Quantities of Hemostatic Proteins During Ex Situ Normothermic Machine Perfusion of Human Livers', Liver Transplantation, vol. 24, no. 9, pp. 1298-1302. https://doi.org/10.1002/lt.25290

Standard

Production of Physiologically Relevant Quantities of Hemostatic Proteins During Ex Situ Normothermic Machine Perfusion of Human Livers. / Karangwa, Shanice A; Adelmeijer, Jelle; Matton, Alix P M; de Meijer, Vincent E; Lisman, Ton; Porte, Robert J.

In: Liver Transplantation, Vol. 24, No. 9, 09.2018, p. 1298-1302.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Vancouver

Karangwa SA, Adelmeijer J, Matton APM, de Meijer VE, Lisman T, Porte RJ. Production of Physiologically Relevant Quantities of Hemostatic Proteins During Ex Situ Normothermic Machine Perfusion of Human Livers. Liver Transplantation. 2018 Sep;24(9):1298-1302. https://doi.org/10.1002/lt.25290


BibTeX

@article{05c98be72fcd4f6da0fc6fc851a03a1a,
title = "Production of Physiologically Relevant Quantities of Hemostatic Proteins During Ex Situ Normothermic Machine Perfusion of Human Livers",
abstract = "Ex-situ normothermic machine perfusion (NMP) of donor livers is an emerging innovation in liver transplantation that has made its transition to clinical trials. NMP is applied in an effort to overcome ischemia-reperfusion injury associated with static cold storage, to improve the quality of sub-optimally functioning donor organs and to permit viability testing of potentially transplantable livers. The in-vivo physiological conditions maintained during ex-situ NMP necessitate the need for a perfusion fluid that mimics the composition of whole blood. To date, perfusion fluids used in NMP studies are composed of either plasma-based solutions or plasma-free solutions consisting of colloids such as Gelofusine1 . The latter avoids the use of human plasma which is scarce, costly and logistically challenging. This article is protected by copyright. All rights reserved.",
author = "Karangwa, {Shanice A} and Jelle Adelmeijer and Matton, {Alix P M} and {de Meijer}, {Vincent E} and Ton Lisman and Porte, {Robert J}",
note = "This article is protected by copyright. All rights reserved.",
year = "2018",
month = "9",
doi = "10.1002/lt.25290",
language = "English",
volume = "24",
pages = "1298--1302",
journal = "Liver Transplantation",
issn = "1527-6465",
publisher = "WILEY",
number = "9",

}

RIS

TY - JOUR

T1 - Production of Physiologically Relevant Quantities of Hemostatic Proteins During Ex Situ Normothermic Machine Perfusion of Human Livers

AU - Karangwa, Shanice A

AU - Adelmeijer, Jelle

AU - Matton, Alix P M

AU - de Meijer, Vincent E

AU - Lisman, Ton

AU - Porte, Robert J

N1 - This article is protected by copyright. All rights reserved.

PY - 2018/9

Y1 - 2018/9

N2 - Ex-situ normothermic machine perfusion (NMP) of donor livers is an emerging innovation in liver transplantation that has made its transition to clinical trials. NMP is applied in an effort to overcome ischemia-reperfusion injury associated with static cold storage, to improve the quality of sub-optimally functioning donor organs and to permit viability testing of potentially transplantable livers. The in-vivo physiological conditions maintained during ex-situ NMP necessitate the need for a perfusion fluid that mimics the composition of whole blood. To date, perfusion fluids used in NMP studies are composed of either plasma-based solutions or plasma-free solutions consisting of colloids such as Gelofusine1 . The latter avoids the use of human plasma which is scarce, costly and logistically challenging. This article is protected by copyright. All rights reserved.

AB - Ex-situ normothermic machine perfusion (NMP) of donor livers is an emerging innovation in liver transplantation that has made its transition to clinical trials. NMP is applied in an effort to overcome ischemia-reperfusion injury associated with static cold storage, to improve the quality of sub-optimally functioning donor organs and to permit viability testing of potentially transplantable livers. The in-vivo physiological conditions maintained during ex-situ NMP necessitate the need for a perfusion fluid that mimics the composition of whole blood. To date, perfusion fluids used in NMP studies are composed of either plasma-based solutions or plasma-free solutions consisting of colloids such as Gelofusine1 . The latter avoids the use of human plasma which is scarce, costly and logistically challenging. This article is protected by copyright. All rights reserved.

U2 - 10.1002/lt.25290

DO - 10.1002/lt.25290

M3 - Comment/Letter to the editor

VL - 24

SP - 1298

EP - 1302

JO - Liver Transplantation

JF - Liver Transplantation

SN - 1527-6465

IS - 9

ER -

ID: 64262976